ID A0A060X7R2_ONCMY Unreviewed; 335 AA.
AC A0A060X7R2;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=KASH domain-containing protein {ECO:0000259|PROSITE:PS51049};
GN ORFNames=GSONMT00015228001 {ECO:0000313|EMBL:CDQ75247.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ75247.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ75247.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ75247.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the nesprin family.
CC {ECO:0000256|ARBA:ARBA00008619}.
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DR EMBL; FR905037; CDQ75247.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A060X7R2; -.
DR STRING; 8022.A0A060X7R2; -.
DR PaxDb; 8022-A0A060X7R2; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR InterPro; IPR026696; AKAP6/CEP68.
DR InterPro; IPR012315; KASH.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR14514:SF3; NESPRIN-1; 1.
DR PANTHER; PTHR14514; PKA ANCHORING PROTEIN; 1.
DR Pfam; PF10541; KASH; 1.
DR SMART; SM01249; KASH; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS51049; KASH; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT TOPO_DOM 1..284
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT TOPO_DOM 306..335
FT /note="Perinuclear space"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT DOMAIN 276..335
FT /note="KASH"
FT /evidence="ECO:0000259|PROSITE:PS51049"
FT REGION 196..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 335 AA; 37364 MW; 92896ECB8637D4D2 CRC64;
MDGHKSQVLS INLSSADFLQ SDPDSKEAWE LRDGLKEMNS RWDWLGSSLE DWRAELQRAL
MQCQEFHELS HGLLLWLENI DRRRNEVVPI PPRLDRETLR AHHRTLTQIK RELLDSQQKA
SSLQELSAQL LVHTQATSQS QPQASKQAQN QLQGSEHLEA QEKVHVIGNR LRLLLREVST
DLEGLERRLE TMDTQDSLPL SAVDKSDISG STSPVSEGTS TSRRRSPRGK SSHAHPGPPE
SGPHHSSQSG AGCASSRSDF PLVPSSSSSS CPPRGQSFIL RVLRAALPLQ LLLLLLIGLA
CLVPMTEEDY SCHHANNFAR SFHPMLRYTN GPPPI
//
