ID A0A060X8C6_ONCMY Unreviewed; 284 AA.
AC A0A060X8C6;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Caspase-3 {ECO:0000256|ARBA:ARBA00039708};
DE EC=3.4.22.56 {ECO:0000256|ARBA:ARBA00038900};
GN Name=casp3 {ECO:0000313|EMBL:BAU69680.1};
GN Synonyms=casp3a1 {ECO:0000313|EMBL:QWC93452.1};
GN ORFNames=GSONMT00050549001 {ECO:0000313|EMBL:CDQ73095.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ73095.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:BAU69680.1}
RP NUCLEOTIDE SEQUENCE.
RA Ojima N.;
RT "Characterization of rainbow trout caspase-3.";
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDQ73095.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [3] {ECO:0000313|EMBL:CDQ73095.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:QWC93452.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=33359598;
RA Zeng C., Hou Z.S., Zhao H.K., Xin Y.R., Liu M.Q., Yang X.D., Wen H.S.,
RA Li J.F.;
RT "Identification and characterization of caspases genes in rainbow trout
RT (Oncorhynchus mykiss) and their expression profiles after Aeromonas
RT salmonicida and Vibrio anguillarum infection.";
RL Dev. Comp. Immunol. 118:0-103987(2021).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Strict requirement for an Asp residue at positions P1 and P4.
CC It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-|- with a
CC hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid
CC residue at P3, although Val or Ala are also accepted at this
CC position.; EC=3.4.22.56; Evidence={ECO:0000256|ARBA:ARBA00036189};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR EMBL; AB477342; BAU69680.1; -; mRNA.
DR EMBL; FR904878; CDQ73095.1; -; Genomic_DNA.
DR EMBL; MT517327; QWC93452.1; -; mRNA.
DR AlphaFoldDB; A0A060X8C6; -.
DR SMR; A0A060X8C6; -.
DR STRING; 8022.A0A060X8C6; -.
DR MEROPS; C14.003; -.
DR PaxDb; 8022-A0A060X8C6; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00032; CASc; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR033139; Caspase_cys_AS.
DR InterPro; IPR016129; Caspase_his_AS.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR10454; CASPASE; 1.
DR PANTHER; PTHR10454:SF198; CASPASE-3; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR PROSITE; PS01122; CASPASE_CYS; 1.
DR PROSITE; PS01121; CASPASE_HIS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
PE 2: Evidence at transcript level;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 52..176
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 190..284
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
SQ SEQUENCE 284 AA; 31215 MW; A305315B953350F7 CRC64;
MSVANYLSAG DCIDARRGDG QECEGPCGGS GSMQVDAKPQ SHCFRYSLSY PSIGQCIIIN
NKNFDRRTGM NVRNGTDVDA GNVIKVFGKL GYKVKIYNDQ TVDQIKYVLT TASKEDHSCS
ASFVCVLLSH GDDSVFFGTD ASIELKSLTS LFRGDRCNSL VGKPKLFFIQ ACRGTDLDVG
IEADSSSDGS STRIPVEADF LYAYSTAPGY YSWRNTQTGS WFIQSLCEMI GKYSKELEVQ
HILTRVNHKV ATEFESASNS PGFDAKKQIP CIVSMLTKEM YFTP
//
