ID A0A060X8M0_ONCMY Unreviewed; 1012 AA.
AC A0A060X8M0;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 {ECO:0000313|Ensembl:ENSOMYP00000067391.1};
GN ORFNames=GSONMT00060845001 {ECO:0000313|EMBL:CDQ75988.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ75988.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ75988.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ75988.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSOMYP00000067391.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FR905098; CDQ75988.1; -; Genomic_DNA.
DR STRING; 8022.A0A060X8M0; -.
DR PaxDb; 8022-A0A060X8M0; -.
DR Ensembl; ENSOMYT00000073403.2; ENSOMYP00000067391.1; ENSOMYG00000031084.2.
DR GeneTree; ENSGT00940000165326; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR Proteomes; UP000694395; Chromosome 25.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd13251; PH_ASAP; 1.
DR Gene3D; 1.25.40.950; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR043593; ASAP.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037844; PH_ASAP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45854:SF1; ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 305..397
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 421..542
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 618..650
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 950..1012
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 288..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 920..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..896
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1012 AA; 113114 MW; EC0E7EE683B124FC CRC64;
MPEHISISDF VALTNEDLAS PTTSIFQSKM SECRNTVSAV EESMDMDQNT LQRMKKMVKA
IHSSGISHAE NKEQYIDVLE NLGNSHLTQD NNEVSTGFLN LAVFTREVTA LFKNLVQNLN
NIISFPLENI LKSELRDSRL ELKKQLEKSW KDYDIKVGKL EKERREKSRQ LGLTKTEGHN
VTEDMERERR TFQLQMCEYL LKIQELKVRQ GPDLLQSLIK YFQAQLNFFQ DGLKAAENLS
PFVEKLASSV HTVRQDQDEE VRQLSQLRDS LRLLLQVEGK EEYLNRKNSG NGYSIHQPQG
NKKYGTEKSG FLQKRSDGIR KVWQKRKCGV KYGCLTISHS TINRPPAKLN LLTCLVRPNP
EERRTFDLVT HNRTYHFQAE DEQECMIWVS VLQNSKEEAL NTALGGDQLQ FPDSGLQELA
RAVITELRRM PGNEACADCG AHDPTWLSTN LGILTCIECS GIHRELGVHY SRIQSLTLDM
LSTSELLLAV SIGNTRFNDI MEASLPNDSI KPLPQSDMNA RKEYIVAKYA ERRYVLRRDR
EEGEPWRVYD AVRSRDLTAL LQLYAMGEDL AKPLAQPEGQ DLRETALHLA VRLEDRSSLA
LVDFLIQNSV CLEKRTREGN TALHYSAQHH KTECLKLLLK GKAVLHTVNS SGETALDIAR
RLQHSQCVEL LELAQSGKFN SQIHVEYMWE TQSQDLYDSE DELDERLSLV PRNLRSSLPY
NGGVGASPSR WSFANAPVAC KTYENVDFLY RNPPANSAPS GVLKPPPPLP AKAIMRGRSD
PQISVSTQEG GRKSPRRCCS NPAPQSSPPS PMLEGQTQGG RPPRSPHGQG GQVRGQRPTA
AWEGQANSGS WSGALDSSTK SSSPQNHIGP VSSEKTTSYR RTNSGGQGKG STAVTSPSCV
ALGSQEELYC SFVTNDSAPG ATTSATPTTS PITVPAPRPR RNAMVSKSRP TQKKVKALVD
CRAVSSDQLA FFKDEVIVVT ATEDPHWWVG HIEGYPSRSG TFPVNYVHKL GD
//
