ID A0A060XB30_ONCMY Unreviewed; 988 AA.
AC A0A060XB30;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=SRCR domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=GSONMT00024835001 {ECO:0000313|EMBL:CDQ76437.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ76437.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ76437.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ76437.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR EMBL; FR905141; CDQ76437.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A060XB30; -.
DR STRING; 8022.A0A060XB30; -.
DR PaxDb; 8022-A0A060XB30; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.40.1400; G protein-activated inward rectifier potassium channel 1; 1.
DR Gene3D; 3.10.250.10; SRCR-like domain; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR041647; IRK_C.
DR InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR InterPro; IPR040445; Kir_TM.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF11; TRANSMEMBRANE SERINE PROTEASE 2; 1.
DR Pfam; PF01007; IRK; 1.
DR Pfam; PF17655; IRK_C; 1.
DR Pfam; PF15494; SRCR_2; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR01320; KIRCHANNEL.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF56487; SRCR-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50287; SRCR_2; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Serine protease {ECO:0000256|RuleBase:RU363034};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 81..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 627..675
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 739..984
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT REGION 199..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..591
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 988 AA; 110935 MW; 7B11D67B371E62CA CRC64;
MFGPEITVSV SLCGLQGQTW QCSVCCVPSG SRPRRLCSST WRFMQGCTAT SAATVTTPSP
ATPPSNATCG HTQVRTASVS IVIFIIPIII TTTVFIIIII TVTTRLSVTM FSTVISNSCA
LYGDYGNYGP PPYPRKNIRP RASLRHNPYN PYRPYLRRVD TRVSLANPNK ISRTTSRGQY
VTMPVHHPKL HPLPVSQRII QSQHKARQTK SAERFSSYDT SSWIEKGSSK PNRGKKTQNK
ATSSSSKSTG DIRHKSSSSN VRQHHRYFTK DGMCRGSSYS SKNKMCDLIG TLVDLKYSWI
LFVFTLCYIV TWAAFAELYF LGAWLRGDME HIQDPQWQPC FEKLNSFHSA LSISMDSQII
NGYGSRVASA NCMDGLVLMM AQSIIESVLD TLMLGCILAK LARPKRRLPT LLFSQHCVVS
ERDERLCLMF NVKTLKETHM LVAEIRAKLI KSHHTKEGEF ILLEQRELTL GMGPDGARLF
TVEPQTVEHV IDEQSPLWGI SADSLEWDTF EIVVMVDGAV QDAGTAFHVR TSYTEDEIFW
GQRFKSHKPL EKRGIGSNHK TSDKNYKVQT ATHSDREMAV RQRHERSPGH DTDSVPSNMP
TRKVHYQYLS DQMLLCNSVT NNIGTGTRKL SSVFYRISPE NSLLEIQLEK VPTWLPVCYE
RWNSSLGTLV CRQLGYLRLQ KGVNLTDIGP NYTDGFIQIT SEHNSSLENI WQLRGSCVTG
KVIALKCFEC GTRAKLPRII GGVEATLGRW PWQVSLYYSN RHTCGGTIIT SQWVVTAAHC
VHNYRLPQVS SWVVYAGIVT RSSAKMSQYI GYPVEKILYN KNYNPRSHDN DIALMKLRTP
LNFSGDRELD CFYTIRPICL PQYERDLPGG TQCWISGWGY TQPDDVLIPA TLKEAPVPLI
STKKCNSSCM YNGEITPRML CAGFTEGKVD ACQGDSGGPL VCQIDNVWRL VGVVSWGTGC
AEPNHPGVYT KVAEFLGWIY DMIEANLH
//
