ID A0A060XDG5_ONCMY Unreviewed; 795 AA.
AC A0A060XDG5;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN ORFNames=GSONMT00054401001 {ECO:0000313|EMBL:CDQ77521.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ77521.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ77521.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ77521.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR EMBL; FR905238; CDQ77521.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A060XDG5; -.
DR STRING; 8022.A0A060XDG5; -.
DR PaxDb; 8022-A0A060XDG5; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF47; ANOCTAMIN; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 20..36
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 91..114
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 174..197
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 17..561
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 330..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 737..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..628
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..724
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 744..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 795 AA; 90896 MW; B169554234A81229 CRC64;
MYLMWLTHFS TPPQTSQDIC CVVFALFNVV WATLFLERWK RREAELAYRW GTLDTPAESL
EDPRPQFRGV KRCSPITDCE EFYYPPWKRT IFRWMVSLPI CLLCLCFVFL AMLVCLEMQE
FVMEIKELPS ITRFIPKILL AIVVTVCGEV YRKIAHWLND MENYRLQSAY ENNLIIKMFF
FEFINSYLSL FYIGFYLKDM ERLKEMLATL LIFRQFLQNI KEVLQPYLYE HHKLGVFTPK
IVWEVLQAIV IKYSRLALGK AQASWTIQSL LGPKGLATHP VNGQTEQNKR GDLKAGYRFT
EEEWDINDTL RQRKISFNEK VDVARDVAMA TQPEDSFPED SPTMVEEGMD PSSIFEMGDD
DSDYELSETK ETSVSPPSGY DTVVCQRRKN PIPEKESTKS WIDPPEEPKS VILTQAEMES
CMQTYEDTLQ DYQEMFIQFG YVVLFSSAFP LAAMCALINN IIEIRSDALK LCTGLQRPFG
QRVESIGQWQ TAMEAMGLIA IMVNCYLIGQ CGQLQRLFPW LSPEMVIISI VVLEHFAILL
KCVIHVAIPD IPGWVADQMA KLEYRRREAF KKHEHQAQQH FQQQLRRRRE EEELQRQAEL
QAEARQESEY HKADHQHHHD KTQGKPGDKP KRPSSLLGNN NVMKLKQIFP QQGKFSTGTA
RSPQSPTGAE AKLPGFLSFK FRKSPELKKE PLSVTPAPGT VVTTGSMNQE KSQSPSRTFS
PGKLFSFSRS EGAVVCANGA QPSKPGDSGP QAAPNTQPTR QDLNTTPSGE ELPSSESEKG
ETRLSSDTDN SGSKC
//
