ID A0A060XEE9_ONCMY Unreviewed; 881 AA.
AC A0A060XEE9;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Cadherin-1 {ECO:0000256|ARBA:ARBA00023893};
DE AltName: Full=Epithelial cadherin {ECO:0000256|ARBA:ARBA00032684};
GN ORFNames=GSONMT00025412001 {ECO:0000313|EMBL:CDQ78018.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ78018.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ78018.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ78018.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
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DR EMBL; FR905281; CDQ78018.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A060XEE9; -.
DR STRING; 8022.A0A060XEE9; -.
DR PaxDb; 8022-A0A060XEE9; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 3.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR014868; Cadherin_pro_dom.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027:SF319; CADHERIN-1; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF08758; Cadherin_pro; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 4.
DR SMART; SM01055; Cadherin_pro; 1.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU003318};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 185..267
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 268..379
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 380..491
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 492..599
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 881 AA; 96713 MW; D444358928D6EA88 CRC64;
MGAFWFVELG VLTLFLQAFN PGSSEESKCL PGFNSEMYIF KVERNHLQSG RRLGKVVFDD
CTSRTSFLFH SEDSRFKVDG DGTLKLKRGL TLHNGHKEFY VSTQSMGKKI KVPVRVLHEA
RHGHHHHHEM TTQPQPGSSL SLPVLNFPKS SGGLKRRKRD WVIPPINFPE NGRGPFPEHM
VQIRSNNDKE VKILYSITGP GADQPPVGLF TVDKNSGFLY VTQPLDREKK DKYILLAHAV
AVGAGKAEAP MEIIVKVIDM NDNKPAFTQD PFMGTVPEAS KPGDEVMQVT ATDADEEGSA
NSDVRYTILS QEPPLPSPNM FVINPVTGMI RVNAPGLDRE NILKYTLQIQ AADLEGNGLT
SFGKAIITVT DSNDNAPQFV TPSYTVSVPE NKVDALVVKM PVTDGDDPHS SAWATTYKIV
DGDPQGLFNV STGPSKLEGI ITTAKPLDFE KNNKYTLLVT VQNEVPFAVP LPTSTATVIV
NVEDVNEAPV FSPVEKMIKK PEDLPIDSDL VLYTATDPDT ARNQKVTYKI RNDLAGWLSI
DKDTGMIKVK SPMDRESTFV QDNKYSVVVL GTDNDEIPAT GTGTLIIELE DVNDNPPTID
ERMIKVCNKE STPQLLSITD KDGAGFAAPY TVQLQGSSLS NWTARMNDTK TGIILTLKTM
LDSGDYTVVL RVSDIQGLHQ ESTIQASVCD CKGADVQCTD KAVAGFGLSS ILGILGAILL
LLLLSLLLLM FLRKRGGEKK EPLLQEDDVR DNIYYYDEEG GGEDDQDFDL SVLHRGLDNR
PDVFRNDIAP TMARPEYRPR PANPADIGNF IDDNLKAADN DPTAPPYDSL LVFDYEGGGS
EAGSLSSLNS SSSGDDQDYD LLQQWGPRFK KLSDMYGGGE D
//
