ID A0A060XHS7_ONCMY Unreviewed; 460 AA.
AC A0A060XHS7;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=GDNF/GAS1 domain-containing protein {ECO:0000259|SMART:SM00907};
GN ORFNames=GSONMT00009380001 {ECO:0000313|EMBL:CDQ78737.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ78737.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ78737.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ78737.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GDNFR family.
CC {ECO:0000256|ARBA:ARBA00005961}.
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DR EMBL; FR905365; CDQ78737.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A060XHS7; -.
DR STRING; 8022.A0A060XHS7; -.
DR PaxDb; 8022-A0A060XHS7; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR Gene3D; 1.10.220.110; GDNF binding domain; 1.
DR InterPro; IPR016017; GDNF/GAS1.
DR InterPro; IPR037193; GDNF_alpha.
DR InterPro; IPR003438; GDNF_rcpt.
DR PANTHER; PTHR10269:SF15; GDNF FAMILY RECEPTOR ALPHA-3; 1.
DR PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR Pfam; PF02351; GDNF; 3.
DR PRINTS; PR01316; GDNFRECEPTOR.
DR SMART; SM00907; GDNF; 3.
DR SUPFAM; SSF110035; GDNF receptor-like; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..460
FT /note="GDNF/GAS1 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001590630"
FT DOMAIN 29..107
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 144..224
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 236..330
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT REGION 338..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 460 AA; 50742 MW; 1CD1CE28C147DC56 CRC64;
MLFLGILLSI FIQDVVTSLP PLPPGIMDCV EAESGCKADP QCKELYSTLR SCVSEEVALQ
GSKARIGCLE ALSALHYPPL LACKCQRGAR REEHCLRVYW SVRILQSYED LEASPYDDSP
VEMSHMASIV AAASSLPLDG QNACLKAAQD CGLYEKCGSL RSEYVLACTK PVPGSDHCNR
QKCHRALRRF LERVPGEYSL GLLFCPCTDK LCGERRRKTI VPSCSYQERD GEQPNCLHLQ
SSCTRDQLCR SRLADFQHNC QSSDHSPSGC FRDSGTVCLK SYAGLIGTIM TPNYLSNSTM
DVALWCNCEG SGNQWKNCLK IQNMFTNNVC LAKSISTMGS SPPRPVESIL PPSPRPSPLD
QQNKLSSNAQ DELSNNANTK TNRDANTLIL FTPLPLSMSV YHRRGPAFSP PTRQNRFCSD
SSATHPAQCL DQVVLCAFPL SAVQTHTSTV YMNIIKTIYI
//
