ID A0A060XJV7_ONCMY Unreviewed; 780 AA.
AC A0A060XJV7;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=GSONMT00027184001 {ECO:0000313|EMBL:CDQ79527.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ79527.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ79527.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ79527.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
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DR EMBL; FR905469; CDQ79527.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A060XJV7; -.
DR STRING; 8022.A0A060XJV7; -.
DR PaxDb; 8022-A0A060XJV7; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0031981; C:nuclear lumen; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR CDD; cd05776; DNA_polB_alpha_exo; 1.
DR Gene3D; 2.40.50.730; -; 1.
DR Gene3D; 3.30.70.2820; -; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR NCBIfam; TIGR00592; pol2; 1.
DR PANTHER; PTHR45861; DNA POLYMERASE ALPHA CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR45861:SF1; DNA POLYMERASE ALPHA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 207..501
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 567..772
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT REGION 59..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 780 AA; 88201 MW; 7EEB9AADAC61CC65 CRC64;
MFSRRVHHWP HQRSKGKRCL FPNSCQSLNQ SLSPFPSLPE DNSLQFDGVD FDEPMEVGLE
QEKEGPANEE EEPETKPAVK VEPKAEPQDL VLLSGKLGGT WGQEEGDSEA PVEVQVDPSR
LPLAEGPEGE LMFRFYWLDA FEDQYSQPGV VYLFGKVWIE SAKAHVSCCV SVKNIERTMH
FLPRERKVNP KTGEETDTPV GMMDVYQEVN DLSEKFKIMK FKSKKVEKSY AFEIADVPTE
SEYLEVRYSA EYPSLPSDLK GATFSKVFGT NTSSLEHFLL SRKIKGPCWL DIKTPQLSSV
PVSWCKVEAV AMRSDLVTVV KDLPPPPLTV MSISLKTVQN PKTHHNEIVS LAALVHHRFH
LDKAPPQPPY QTHFCVVSKP NDCIFPYDFM DAVKKKNGKV EIAATERTLL GFFLAKMHKL
DPDIVVGHDI FGFDLEVLLQ RITVCKVPHW SKIGRLKRSN MPKLGGRSGF AEKSATCGRL
VCDVEISAKE LIRCKSYHLT ELAAQVLKTE RATIPAENIK NLYSDSPHLL YLLELTWTDA
KLILQIMCEL NVLPLALQIT NIAGNVLSRT LMGGRSERNE YLLLHAFHDK NYIVPDKPSF
KKAQQELAEG EEEGDSGKGK SRRKKAAYAG GLVLDPKVGF YDKFVLLLDF NSLYPSIIQE
FNICFTTVQR EAHSTRKKTE EHDPDEIPEV PDADLEMGIL PKEIRKLVER RKQVKQLMKA
QDINPDLYLQ YDIRQKALKL TANSMYGCLG FSFSRFYAKP LAALVTHKGR EVSYVLLGIL
//
