ID A0A060XKY7_ONCMY Unreviewed; 480 AA.
AC A0A060XKY7;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=TNFR-Cys domain-containing protein {ECO:0000259|PROSITE:PS50050};
GN ORFNames=GSONMT00048384001 {ECO:0000313|EMBL:CDQ77974.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ77974.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ77974.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ77974.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; FR905276; CDQ77974.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A060XKY7; -.
DR STRING; 8022.A0A060XKY7; -.
DR PaxDb; 8022-A0A060XKY7; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00185; TNFRSF; 1.
DR CDD; cd15835; TNFRSF1B_teleost; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR008063; Fas_rcpt.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR PANTHER; PTHR46875; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 5; 1.
DR PANTHER; PTHR46875:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 5; 1.
DR Pfam; PF00020; TNFR_c6; 1.
DR PRINTS; PR01680; TNFACTORR6.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 55..93
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 55..93
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 95..137
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 95..137
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REGION 226..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..400
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 56..71
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 72..85
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 75..93
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 96..111
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 480 AA; 51791 MW; EF8C5BCDB942B0BD CRC64;
MDFSQDLKGA IIIVSIMILS TVSGILTVRI LLAIMVQRVE NTVYTLPYTP DSAEACRNKT
AEYYNTLINL CCSKCAPGTR LKNECSTTSD TVCEPCPSGQ YSGTFNYFTK CFRCPKCSED
KGLQYAQDCS STTKTQCMCQ TGKFCIMEQH PNCKECGSYT HCQPGHGVAI EGTTDSDVNC
APCPNGTFSD QHSYTQTCQH HTDCVSQRRG VLTYGNTTSN AVCGPKVRPP TRPPTTIPTS
GTGHTTPSLQ NLHIGGKSPG FDLRIVSGVI GGVIGGVILL LIIGTVIYKK AFIGSRLVSS
IEDRNGNWEA IKFDSDGPMV LQNSSFITSY REQQQCLMGK GNCSNPSQAE NQQDTRRTWV
SECSNSLEGL SIGPLQSTPP QSSTQPSPQP TSPQPTSPLP SSPLVNVNIT VNYPVTLGNG
SCATPTSTHI DSSQADPELP LSREEEVHVN MPQQEGGKEA LTAIQEKPNP DVISQSRTVY
//
