ID A0A060XQZ8_ONCMY Unreviewed; 913 AA.
AC A0A060XQZ8;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=Disabled homolog 2-interacting protein-like {ECO:0008006|Google:ProtNLM};
GN ORFNames=GSONMT00005450001 {ECO:0000313|EMBL:CDQ79320.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ79320.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ79320.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ79320.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FR905438; CDQ79320.1; -; Genomic_DNA.
DR STRING; 8022.A0A060XQZ8; -.
DR PaxDb; 8022-A0A060XQZ8; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF26; DISABLED HOMOLOG 2-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380}.
FT DOMAIN 1..78
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 69..187
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 247..439
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 530..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..807
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..867
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 913 AA; 100681 MW; AD2A2597011051D0 CRC64;
MPRLKESRSH ESLLSPSSAV EALDLSMEDE VLIKPVHGSI LGQDYCFEVT TSTGTKCFSC
RSSAERDKWM ENLRRAVHPN KDNSRRVENL LKLWIIEAKD LPAKKRYFCE LCLDDTLYAR
TTCKFKMDNV FWGEHFEFNN LPSVKSVTVH LYKESDKKKK KDKNNYVGLV NIPVGAVTGR
QFVEKWYSVS TPNPNKGKTP GPMIRLKSRY QSMSILPMES YKEFAEYITN NYMLLCSILE
PGLSVKNKEE MASALVHILQ STGKAKDFLT DLMMSEVDRC GENEHLIFRE NTLATKAIEE
YLKLVGQKYL QDALGEFIKA LYESDENCEV DPGKCSSGDL PENQSNLKMC CELAFCKIID
SYRVFPRELK EVFASWRQQC SSRGRPDISE RLISASLFLR FLCPAVMSPS LFNLMQEYPD
DRTARTLTLI AKVTQNLANF TKFGNKEEYM SFMNHFLEHE WTNMQRFLLE ISNPETISNT
AGFEGYIDLG RELSSLHSLL AEDVSQLDQS TASKLGPLAR ILRDVNSALT NPSGVQVSTP
TDGTGSPPLP LPLASCSLST GLPLHKIVVD SELSGLVDFT RLPSPTPENK DIFFVTRNSG
IQQSPARSSS YSEANEAEVQ LPNSSKSLSM VDLQDSRSLE STPGPSPGSP SDMLFNDSQS
PVTPGPGGWA ARTPQGIIPT PGPGPTLRRT GQTPTTPSTE SSTPGRPTQL LAPLSFQNPV
YQMATGMTMS VSPRGPLADS GSDGHSSVSS QGNNTEDTPK HPGVFLTQGV AVGSGGGSSS
EFTTRRQLSL GEHQPNVPRQ NSAGPQRRID QPPPPVTRGR TPPNMLQTAY PGPRPSSGSM
MSSSPDWGPS GGNRLRQQSS SSKGDSPETK QRTMHKSIMD CVEAAVIEHL HSDSNVLXXC
IEHLHSDSNV LKV
//
