ID A0A060XUU4_ONCMY Unreviewed; 757 AA.
AC A0A060XUU4;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Rho GTPase activating protein 10 {ECO:0000313|Ensembl:ENSOMYP00000022324.1};
GN ORFNames=GSONMT00041418001 {ECO:0000313|EMBL:CDQ83052.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ83052.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ83052.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ83052.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSOMYP00000022324.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; FR906098; CDQ83052.1; -; Genomic_DNA.
DR STRING; 8022.A0A060XUU4; -.
DR PaxDb; 8022-A0A060XUU4; -.
DR Ensembl; ENSOMYT00000024479.2; ENSOMYP00000022324.1; ENSOMYG00000010692.2.
DR GeneTree; ENSGT00940000159559; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR Proteomes; UP000694395; Chromosome 10.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF5; RHO GTPASE-ACTIVATING PROTEIN 10; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 265..372
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 389..573
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 699..757
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 576..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 87..114
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 583..597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 757 AA; 85030 MW; 296515A5B0324465 CRC64;
MGLHPLEFSE CYLDSPVFRE KIKSHEAELD KTNRFIKELY KDGKNLINAT KQLVLAQRKF
AQSLGEFQFE YIGDAKTDDE RCIDESLQEF SNFLKNLEDQ RELMMRNITE TLMKPLEKFR
KEQLGSAKAE RKKYEKETEK YYSSLEKLLN MSAKKKEPQL QEADSQVETI RQHFQEESLD
YVCKLQEIQE RKKFDCVEPM LAFFQTVFTF YHQGFELAND FNHYKKALQI NIQNTRSRFE
GTRVEVFELM KRIREVPQEY RQTSPISSEG YLYVQEKRPP PFGSSWVKRY CTFVKEQKIL
HMVTFDHRSG GKMGETESVT LKSCVRKTTD MLDRRFCLDI EITDRPGTVL TVQSLSEDDH
KFWIHAMGGK EPAGQYLGKT YSKERGIDAQ LDDVGLSFVK NAINAIETRG INDQGLYRVV
GVSSKVQKLL SLMIDEKSND VDLSTCEDWD VKTITSTLKL YLRSLPEPLM TYGLYKDFIA
PAKGGSPESR SQAIHCLVHK LPEKNRLVLG LLLKHLATVA AHSKLNLMTV ANLGVVFGPT
LMRPQEDTVA AIMDLKFQNI VVEILIEQHE KIFGDVPGPS SPGLSAPTRQ SKKLSVRQNR
PLAVYNPKKV DLQTVSPTSP DVGSNSDEAS LGSNESVSSQ STASGTPPEK ANHGRLLASL
STGDSPGACI AVAASRLNSG ALTKTSSDGD KTVDGVTGGG GKRAMAVYPC EAEHDSELSF
QVGAIFSAVA PSREPGWLEG ELEGKKGLIP ENYVEML
//
