ID A0A060Z6G8_ONCMY Unreviewed; 361 AA.
AC A0A060Z6G8;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Flotillin {ECO:0000256|RuleBase:RU366054};
GN ORFNames=GSONMT00004497001 {ECO:0000313|EMBL:CDQ96890.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:CDQ96890.1, ECO:0000313|Proteomes:UP000193380};
RN [1] {ECO:0000313|EMBL:CDQ96890.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [2] {ECO:0000313|EMBL:CDQ96890.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as a scaffolding protein within caveolar membranes,
CC functionally participating in formation of caveolae or caveolae-like
CC vesicles. {ECO:0000256|ARBA:ARBA00025336}.
CC -!- SUBUNIT: Heterooligomeric complex. {ECO:0000256|RuleBase:RU366054}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Melanosome
CC {ECO:0000256|ARBA:ARBA00004223}. Membrane raft
CC {ECO:0000256|ARBA:ARBA00004285}. Membrane, caveola
CC {ECO:0000256|ARBA:ARBA00004543}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004543}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170, ECO:0000256|RuleBase:RU366054};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}. Endosome
CC {ECO:0000256|RuleBase:RU366054}.
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family. Flotillin subfamily.
CC {ECO:0000256|ARBA:ARBA00007161, ECO:0000256|RuleBase:RU366054}.
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DR EMBL; FR927799; CDQ96890.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A060Z6G8; -.
DR STRING; 8022.A0A060Z6G8; -.
DR PaxDb; 8022-A0A060Z6G8; -.
DR Proteomes; UP000193380; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd03399; SPFH_flotillin; 1.
DR Gene3D; 3.30.479.30; Band 7 domain; 1.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR027705; Flotillin_fam.
DR PANTHER; PTHR13806:SF47; FLOTILLIN-1; 1.
DR PANTHER; PTHR13806; FLOTILLIN-RELATED; 1.
DR Pfam; PF01145; Band_7; 1.
DR SMART; SM00244; PHB; 1.
DR SUPFAM; SSF117892; Band 7/SPFH domain; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366054};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380}.
FT DOMAIN 84..266
FT /note="Band 7"
FT /evidence="ECO:0000259|SMART:SM00244"
SQ SEQUENCE 361 AA; 41165 MW; 1E65D292C91A1B45 CRC64;
MFHTCGPNEA MVVSGFGRSP PLMIAGGRVF VLPCIQQIQR ITLNTLTLNV KSDKVYTRHG
VPISVTGIAQ VKIQGQNKEM LATACQMFMG KSEAEVSNIA LETLEGHQRA IIAHLTVEEI
YQDRKKFSEQ VFKVASSDLV NMGIGVVSYT LKDVHDDQDY LNSLGKARTA QVQKDARIGE
AQYKRDAVIR EAQAMQEKVS AQYLNEIEMA KAQRDYELKK ASYDYEVNTK KAESEMAYQL
QVAKTKQRIE EETMQVKVVE RSQQIMLQEQ EITRKEMELE ATVKKPAEAE RYRLERLAEA
ERYVTLPRAS LRNVSYTLNM PPKMRQFLCK SCPKNAPAFT QKLSVVKRKL EVRMYFSSCR
L
//