ID A0A061ADT8_CAEEL Unreviewed; 1394 AA.
AC A0A061ADT8;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE SubName: Full=Calcium-dependent secretion activator {ECO:0000313|EMBL:CDR32668.1};
GN Name=unc-31 {ECO:0000313|EMBL:CDR32668.1,
GN ECO:0000313|WormBase:ZK897.1l};
GN ORFNames=CELE_ZK897.1 {ECO:0000313|EMBL:CDR32668.1}, ZK897.1
GN {ECO:0000313|WormBase:ZK897.1l};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CDR32668.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CDR32668.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CDR32668.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284604; CDR32668.1; -; Genomic_DNA.
DR RefSeq; NP_001293903.1; NM_001306974.1.
DR SMR; A0A061ADT8; -.
DR EnsemblMetazoa; ZK897.1l.1; ZK897.1l.1; WBGene00006767.
DR GeneID; 178233; -.
DR AGR; WB:WBGene00006767; -.
DR WormBase; ZK897.1l; CE49750; WBGene00006767; unc-31.
DR OrthoDB; 5399598at2759; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00006767; Expressed in larva and 3 other cell types or tissues.
DR ExpressionAtlas; A0A061ADT8; baseline.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:1990504; P:dense core granule exocytosis; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016079; P:synaptic vesicle exocytosis; IEA:InterPro.
DR CDD; cd01234; PH_CADPS; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR033227; CAPS.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12166; CALCIUM-DEPENDENT SECRETION ACTIVATOR; 1.
DR PANTHER; PTHR12166:SF8; CALCIUM-DEPENDENT SECRETION ACTIVATOR; 1.
DR Pfam; PF06292; MUN; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM01145; DUF1041; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Proteomics identification {ECO:0007829|EPD:A0A061ADT8};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 442..559
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 581..687
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 980..1111
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1394 AA; 157981 MW; C95B837EDD282EE7 CRC64;
MLGASSSEEE DDDFQEDHDS LPIAQVKKRS LLSGAMTPRS SSPAPSDSVS QTNSLKRNNS
SSQGRRKDSV QSQTPARSPM RMNAPSPMPQ ARIMSNVSKP IMQNSQEFDG DEEEGEEGST
TVVGSGDECG GPALSKEEQE RMKAEREEED HKKNLQMYMF LARCIAYPFN GQQTGDMARR
QMKVNKQELA RIRERFTLFL KGETNIAADE AFTKAIQSYF EVFLKSERVQ KVVHAGGFSQ
HDFREVFRLN IEKRVRSLPD IEGLSKDTVL NSWLAKFDAI IKGDETDQNR NARGRSRNPQ
NAMSADAVLG KEQLYDVFQQ ILGVKKFEHQ IIFNALQLDN PDEQAAAIRR EFATREEALK
DPIKMKRLTP KFVVKDMETL YMDEVRMSIN TLIGNLETVP VTTRGATVGK RKDKSRSRSI
EDLSLFNSLK RRTSSGSLNK GDSEDGDVTL TKSDVSLALS MEVVVMEVQG LKSVQPSKIV
YCTMEVDGHK LQTDHAEASK PKWDTQGDFS TKNPLPVVKV KLYTEVKSMI AFEDKELGKV
IIQPTPNCAR SPEWYTMTLP KSSQDQNLKI RIAIRVEKPP NLKYCGYCYC IGRNAWKKWK
KRFFCLVQVS QYAFAVCSFR QKKADPTEFI QLDGFTIDYM PESDPELSAQ GGKHFFTAIK
EGDELKFATD DENERHLWVQ ALYRATGQAY KPVPPKQSTI APKAQGFQDK ASKHGMDAMI
QADSINFDHD HFYSDVQRLT LDFRINEPIC SLGWFSPGQA FVLEEYSARY MVRGCFRHVT
LLSNLLDKAD DGLLIDPALI HYSFAFCASH VHGNRCMPDR QGPEGVGTVT LEEKEKFQEI
KERLRVLLEK QITNFRYCFP FGRPEGALKG TLGLLERVLM KDVVSPVPPE EVRAVIRKCL
EDAALVNYTR ICNEAKIEQR MGIDVSPAQR IEDMIRVTEF CIDLLKENEE HHGEQLRGAF
AWFSDLLSDH SEIFWSLYSV DLDSALEVQP HDSWDSFPLF QMLNDFLLSE SSLKGGIFHN
KIVQQFQPLV VRYIDLMEHS IAQAIDKGFS KEKWESRKEG CATSEDIYWK LDALHTFVID
LNWPEEDFRK YLQTKMKSLT SDMISKVSDC TFTAFDSWMQ RAKKSTDYML PSEVCVQINV
MFSSKSRAVR VTVDSGEYKY QSKLDETLET MLKTMESCIQ EKLHGVLESV LSRLARYDEG
NPIGAILNIA PKPASIFNKL KTMAGDTSAQ ATTTARQPLT AQQSSGQIGN SYVTFFHGCT
ELLRQVIIDE IWVNGLFEHW YDNQMKSINE WLTERLQQSL SATQYISLST IVKKVYQDFS
LQGIDEERLN SKTYQSISRR LQLEESNSHI QEAAINGSAQ GSVFPTSLGN ATAAVSNMSS
MVEGAGAKMF SLFK
//
