ID A0A061AZ22_CYBFA Unreviewed; 890 AA.
AC A0A061AZ22;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=CYFA0S09e04214g1_1 {ECO:0000313|EMBL:CDR42467.1};
DE SubName: Full=Manganese resistance protein MNR2 {ECO:0000313|EMBL:ONH67499.1};
GN ORFNames=BON22_2737 {ECO:0000313|EMBL:ONH67499.1}, CYFA0S_09e04214g
GN {ECO:0000313|EMBL:CDR42467.1};
OS Cyberlindnera fabianii (Yeast) (Hansenula fabianii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Cyberlindnera.
OX NCBI_TaxID=36022 {ECO:0000313|EMBL:CDR42467.1};
RN [1] {ECO:0000313|EMBL:CDR42467.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=YJS4271 {ECO:0000313|EMBL:CDR42467.1};
RX PubMed=25103752; DOI=10.1128/genomeA.00638-14;
RA Freel K.C., Sarilar V., Neuveglise C., Devillers H., Friedrich A.,
RA Schacherer J.;
RT "Genome sequence of the yeast Cyberlindnera fabianii (Hansenula
RT fabianii).";
RL Genome Announc. 2:E00638-E00638(2014).
RN [2] {ECO:0000313|Proteomes:UP000189513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=65 {ECO:0000313|Proteomes:UP000189513};
RX PubMed=28385833; DOI=10.1128/genomeA.00064-17;
RA van Rijswijck I.M.H., Derks M.F.L., Abee T., de Ridder D., Smid E.J.;
RT "Genome sequences of Cyberlindnera fabianii 65, Pichia kudriavzevii 129,
RT and Saccharomyces cerevisiae 131 isolated from fermented masau fruits in
RT Zimbabwe.";
RL Genome Announc. 5:E00064-E00064(2017).
RN [3] {ECO:0000313|EMBL:ONH67499.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=65 {ECO:0000313|EMBL:ONH67499.1};
RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000256|ARBA:ARBA00009765}.
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DR EMBL; LK052894; CDR42467.1; -; Genomic_DNA.
DR EMBL; MPUK01000004; ONH67499.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A061AZ22; -.
DR STRING; 36022.A0A061AZ22; -.
DR VEuPathDB; FungiDB:BON22_2737; -.
DR OMA; DVCFPDY; -.
DR OrthoDB; 1358357at2759; -.
DR Proteomes; UP000189513; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR CDD; cd12829; Alr1p-like; 1.
DR Gene3D; 3.30.460.20; CorA soluble domain-like; 1.
DR Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 2.
DR InterPro; IPR044089; Alr1-like.
DR InterPro; IPR045861; CorA_cytoplasmic_dom.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR PANTHER; PTHR21535; MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8; 1.
DR PANTHER; PTHR21535:SF51; MANGANESE RESISTANCE PROTEIN MNR2; 1.
DR Pfam; PF01544; CorA; 2.
DR SUPFAM; SSF143865; CorA soluble domain-like; 1.
DR SUPFAM; SSF144083; Magnesium transport protein CorA, transmembrane region; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189513};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 827..850
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 862..883
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..584
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 890 AA; 100394 MW; D883952CB0334ABF CRC64;
MDSDSEPLLP EDPLSEDPLP SSNSQTRPRQ TSRGSQGHVP PSSPPRRRRN TFTRSSFSQS
SGSPRALNAG NITAPALYSN DVHGAYLNDV ESSRANSLSS TGGFRDLRSY DPRALPSTRR
GSFRRLTTTG DTPVLAQNAS PSLAERWVQR QSLLQGQPTT HYGSMAHHSG STRIDMDILE
RENEIRGGAP ASSHSHVDAD DFDSKPSTRR NSDASSLDDV CFPLDVLDNI QGPKNWPDLS
VLEEFQKEET ERLQQEATRE MAAANMRYDQ KSETGSVDTH SAQVEFSHPI VTKVDTSAAI
SQPQPLSQHF ANQKINETET LNGRLRPPKI NPFDKNNRFN KASNAEFLKT INYPPHIINN
NPEHFRFTYF REDLDSTVHS PSISGLLQPD QKFADLFDCK EYSKQQMLRP STSSLQVPST
SSNTASGTPI RNATPAPSDT KASSIDDEVT PFWLDVLNPT EEEMKVISKT FQIHPLTTED
IFLGETREKV ELFKDYYFVC FRSFDIVQER KKKNRRRPHL DEDEANAASA SSIKKTIWSQ
FFGNKPFSSK SSSLRSESSS ARKRRRQIER EQYQRKSGEK HIPKNDELEP LNVYIIVFRH
AVLTFHFAPT PHPVNVRRRA RFLREYLTVS ADWIAYALID DITDAFGPMI ESIEDEVNQI
EDAILRMHPG NDSSDEDSSD DEDDFEMLAS SQKSLLRNRK GSVVDGRSIK SVSSSSTRST
SSNVIEWKKK GDLLKRIGES RKRVMALLRL LGSKVDVIKG FAKRCNEQWE VAPRSEIGMY
LGDIQDHIVT MVQSLNHYEK LLARSHSNYL AQINIDMTKV NNDTNDVLGK ISILGTVVLP
MNIVTGMWGM NVIVPGQDYD GLLWFWGIVF GMFVFAFCSY VYMKRLSGLD
//
