ID A0A061BGL6_CYBFA Unreviewed; 549 AA.
AC A0A061BGL6;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=CYFA0S22e00430g1_1 {ECO:0000313|EMBL:CDR46134.1};
DE SubName: Full=General amino acid permease AGP3 {ECO:0000313|EMBL:ONH68388.1};
GN ORFNames=BON22_1933 {ECO:0000313|EMBL:ONH68388.1}, CYFA0S_22e00430g
GN {ECO:0000313|EMBL:CDR46134.1};
OS Cyberlindnera fabianii (Yeast) (Hansenula fabianii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Cyberlindnera.
OX NCBI_TaxID=36022 {ECO:0000313|EMBL:CDR46134.1};
RN [1] {ECO:0000313|EMBL:CDR46134.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=YJS4271 {ECO:0000313|EMBL:CDR46134.1};
RX PubMed=25103752; DOI=10.1128/genomeA.00638-14;
RA Freel K.C., Sarilar V., Neuveglise C., Devillers H., Friedrich A.,
RA Schacherer J.;
RT "Genome sequence of the yeast Cyberlindnera fabianii (Hansenula
RT fabianii).";
RL Genome Announc. 2:E00638-E00638(2014).
RN [2] {ECO:0000313|Proteomes:UP000189513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=65 {ECO:0000313|Proteomes:UP000189513};
RX PubMed=28385833; DOI=10.1128/genomeA.00064-17;
RA van Rijswijck I.M.H., Derks M.F.L., Abee T., de Ridder D., Smid E.J.;
RT "Genome sequences of Cyberlindnera fabianii 65, Pichia kudriavzevii 129,
RT and Saccharomyces cerevisiae 131 isolated from fermented masau fruits in
RT Zimbabwe.";
RL Genome Announc. 5:E00064-E00064(2017).
RN [3] {ECO:0000313|EMBL:ONH68388.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=65 {ECO:0000313|EMBL:ONH68388.1};
RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. YAT (TC 2.A.3.10) family. {ECO:0000256|ARBA:ARBA00006983}.
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DR EMBL; LK052907; CDR46134.1; -; Genomic_DNA.
DR EMBL; MPUK01000003; ONH68388.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A061BGL6; -.
DR STRING; 36022.A0A061BGL6; -.
DR VEuPathDB; FungiDB:BON22_1933; -.
DR OMA; WRILFVY; -.
DR OrthoDB; 1351468at2759; -.
DR Proteomes; UP000189513; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR004840; Amoino_acid_permease_CS.
DR PANTHER; PTHR43341; AMINO ACID PERMEASE; 1.
DR PANTHER; PTHR43341:SF26; GENERAL AMINO ACID PERMEASE AGP3; 1.
DR Pfam; PF00324; AA_permease; 1.
DR PIRSF; PIRSF006060; AA_transporter; 1.
DR PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE 3: Inferred from homology;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189513};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 63..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 60..504
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 60456 MW; 13E6784BC31F7AA1 CRC64;
MARLFNRGAR NLSDSSYPEI SQSNDTKVPN DVEAYNDESA SIEVNSYDST GVKRGLKDRH
ISLIALAGII GPGILVGAGI TLRTGGPLAL LIAVILIGIV AFSIMVSLGE IISIYPSGNG
FATLARRFHS NSLGAVSGYN YVIVWFCVLS NEYNTLSSIM RYWDVDEKIP LYGYILIFWV
FFECFQLLGV SAFGEAEYWL ALIKIFGLIA YYIFSIIYIS GGIKGRPAFG FHYWNDPGAL
THGFRGVASV FTYVSTFFSG VEGISSTVSE TKNPSRAIPR AIRQTVFRII FIYLFIAIFY
GATVPSNDPN LLASERALKS PIGIAIVNAG WNGGTHLVNA FILITCLSAV NSSIYIGSRT
LTHLSSEGLA PRIIAWKNKR GVPVVAVTLM NLLGLLSIMN MSTGAANAFT YIVNISGVAV
FIVWGIISYT HIRVRSAWKK QGFDLSQLPY RTRLFPWIAW FGLAANVFLG LVQGWTTLSP
FVAGDFVDAY ILLPFAVVIY VVTGLVKGFS VVDLHTIDLD EGRRLDLDEA TVTDPDDKIP
WFKRFWKEF
//
