ID A0A061CZ03_BABBI Unreviewed; 459 AA.
AC A0A061CZ03;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Peptidase C1A papain C-terminal domain-containing protein {ECO:0000259|SMART:SM00645};
GN ORFNames=BBBOND_0101800 {ECO:0000313|EMBL:CDR93851.1};
OS Babesia bigemina.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=5866 {ECO:0000313|EMBL:CDR93851.1, ECO:0000313|Proteomes:UP000033188};
RN [1] {ECO:0000313|Proteomes:UP000033188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bond {ECO:0000313|Proteomes:UP000033188};
RX PubMed=24799432; DOI=10.1093/nar/gku322;
RA Jackson A.P., Otto T.D., Darby A., Ramaprasad A., Xia D., Echaide I.E.,
RA Farber M., Gahlot S., Gamble J., Gupta D., Gupta Y., Jackson L.,
RA Malandrin L., Malas T.B., Moussa E., Nair M., Reid AJ., Sanders M.,
RA Sharma J., Tracey A., Quail M.A., Weir W., Wastling J.M., Hall N.,
RA Willadsen P., Lingelbach K., Shiels B., Tait A., Berriman M., Allred D.R.,
RA Pain A.;
RT "The evolutionary dynamics of variant antigen genes in Babesia reveal a
RT history of genomic innovation underlying host-parasite interaction.";
RL Nucleic Acids Res. 42:7113-7131(2014).
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; LK391707; CDR93851.1; -; Genomic_DNA.
DR RefSeq; XP_012766037.1; XM_012910583.1.
DR AlphaFoldDB; A0A061CZ03; -.
DR STRING; 5866.A0A061CZ03; -.
DR EnsemblProtists; CDR93851; CDR93851; BBBOND_0101800.
DR GeneID; 24562392; -.
DR KEGG; bbig:BBBOND_0101800; -.
DR VEuPathDB; PiroplasmaDB:BBBOND_0101800; -.
DR OMA; CKSADWI; -.
DR OrthoDB; 5472948at2759; -.
DR Proteomes; UP000033188; Chromosome 1.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF741; CATHEPSIN K; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000033188};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 242..441
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 459 AA; 52442 MW; F065E8BD1B10BB20 CRC64;
MEDISLPFMR NIRLGMNEVV HEQQHIVHEQ ENVILEKNWL LPERREVVSE LTEHVDETVE
VDYGKSLESA HSNPHYSLLV DKIREYKLEV IPGPFLACVQ KGWFINCADK QNDIKGVLDW
EIRAIVHELS ERREEFDEQN EVETIIAYKK FITVNGSHYG NEKEFVKKYF NFKTTKKLID
EHNSNPDKLY TMAYSWASEF SDSELGIALS TNGWSRPMYM YENGRFIDTS MYSGSKNVDD
GDIVHKDWRN TNAIGPVVDQ GSCGSCWAVA VAGLVDAYRA ITTGQRLQHS VQQILDCTSQ
RYNCVRGGNQ EKALVYASTT GLCIEPAYPY LGRKTACREK TCGEKFKVDN IKRLNARMIQ
EHLRSHGPVM IIIRLSRAFM HYSSGIFDGS CDSTLMHSVL IVGYGENTKR KTKYWIVKNS
WGDRWGDGGY FKLHNLPLSP AGTPLFCGVD TYAFGLTTH
//
