ID A0A061CZ78_BABBI Unreviewed; 2221 AA.
AC A0A061CZ78;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=Bromo domain-containing protein {ECO:0000259|PROSITE:PS50014};
GN ORFNames=BBBOND_0100670 {ECO:0000313|EMBL:CDR93738.1};
OS Babesia bigemina.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=5866 {ECO:0000313|EMBL:CDR93738.1, ECO:0000313|Proteomes:UP000033188};
RN [1] {ECO:0000313|Proteomes:UP000033188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bond {ECO:0000313|Proteomes:UP000033188};
RX PubMed=24799432; DOI=10.1093/nar/gku322;
RA Jackson A.P., Otto T.D., Darby A., Ramaprasad A., Xia D., Echaide I.E.,
RA Farber M., Gahlot S., Gamble J., Gupta D., Gupta Y., Jackson L.,
RA Malandrin L., Malas T.B., Moussa E., Nair M., Reid AJ., Sanders M.,
RA Sharma J., Tracey A., Quail M.A., Weir W., Wastling J.M., Hall N.,
RA Willadsen P., Lingelbach K., Shiels B., Tait A., Berriman M., Allred D.R.,
RA Pain A.;
RT "The evolutionary dynamics of variant antigen genes in Babesia reveal a
RT history of genomic innovation underlying host-parasite interaction.";
RL Nucleic Acids Res. 42:7113-7131(2014).
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DR EMBL; LK391707; CDR93738.1; -; Genomic_DNA.
DR RefSeq; XP_012765924.1; XM_012910470.1.
DR STRING; 5866.A0A061CZ78; -.
DR EnsemblProtists; CDR93738; CDR93738; BBBOND_0100670.
DR GeneID; 24562279; -.
DR KEGG; bbig:BBBOND_0100670; -.
DR VEuPathDB; PiroplasmaDB:BBBOND_0100670; -.
DR OrthoDB; 227677at2759; -.
DR Proteomes; UP000033188; Chromosome 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR16266:SF17; BRWD3; 1.
DR PANTHER; PTHR16266; WD REPEAT DOMAIN 9; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Reference proteome {ECO:0000313|Proteomes:UP000033188};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 203..227
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1908..1975
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 519..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1263..1391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1416..1440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2028..2056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2085..2221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1342..1360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2104..2129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2136..2180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2181..2213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2221 AA; 244281 MW; 81F6BB3100910A6D CRC64;
MKRQRSPQIN RPYAAVLDGL DGVLRRYHHS VKTWHAEGSV CAQRDAATDV SSTQKGFGAN
VGASFDEEAA PSPESATSRV MEASNALPDL LGGILYDFGR VMQRESSRFD AFDVLYRAVA
KVRDREAAVK AVKHRRRSAV PPVNVYHQLL ARRMGRGSAV SALGDRPYRK VAKRFKRAAN
VWGHHCCLDE IDPSKPYNEP PQVRCIRFDR TGDVLITGGD EGIIKLWHTF NCTLITSLRK
HAGGVVSMDV HPNNYFILSC CDGGEMWLWE INGNLYRPHK RVSSPFKYLW CRFASFGGSV
GGVATGFSDR CEREIDSTLV VCVTTDSRLS VYRMRDLVVS SSGNNVVREV APLYVVELFN
HNIKAYDVSR PLMHDHSFLI AIGIEPMFLE ELRLADDAAS SALSILQGEA ASRSADRAQG
QYGKITSNAL CALFNISTGS FLASFGDSAA ANSASGMDLD TTAPSVPERR SSVPEGEVGT
EFCVCDVSMD AFLDVAGRCR CCLKPVRTFT FREVPRSSPR DCLAHSEESS PNARGSKADA
GPFSRPSAPH FCWKVDANEL ETYIRRELEG YAIHEESQVA ASVRFGTNSM PFGRLTSTVV
FPSYMDTPYL LFDALDAEQR DTGNFDDLIY HVQRGHELSP DVCFANHSLN HVTGSDDGKV
FLWVHCGSTV KFRSTPLPTR CINRWVCNDS SETAPCRQAP AIFDPAFIAE PPVTVAECAA
DAPIGLFPDT AFSSTQEGAD VGRGSTFAPM DVDIAKSEDT SMQNTDLATE AVDTSANVTE
LDLTVINSGT SEPAPPSSRD DASEKGKRHG HGAASLASGH LPKDGDSNAV AEMEVEECHD
YCRPPWLTDL TSEDLDVCDT FLASDRVKPS MREKEVYQSR NAPSKLFKEG DSSKQHMSES
GHHYMVTAIA WSVNDEYIFI ADSIVTRFNV KKLITASRTI LSGVSVFTSQ GIPVADFLHN
EISHHVGCVK PHPLTDDLAL VITYGGVIYV LSVESKSVVR KLDCGPNAVW LDADWHPGGM
YFAACQSFGC FSLFTVDGLL SNYRATLNNQ CGYSDMLPIN TSAFYSGAEN ESVDMRRYHY
GSNLMPPLEL DGKGCSESLR FYTASSVHTV LDDNHCEVLY ACSPVAMQVD DTKLWRNRLL
DMSVVPAHLW LPISVLSRIP LDINVVEFLQ WHFGVYGKCD VPELIAWFLC VNKLDVLGNF
TNRVRRVVCP YGGVTCVACQ HIITSSDRAE RYAELSVEQH GAKSKVNERG DIIACLPIAL
RPQSSTAPHP PAAPIERRPQ AVSPLNRANA AATTTRYNQG SRAQVVSRSS EGGRSGSGTR
HTSSSRLPPT RVQPPRGAAA RPSTGASSTT AQTFTDAAHT RASPRRTAAP VATSPAPGSP
KETPASNRAT SQMQMGLAEI DRALARVTSD ERTVRRLRRE MRVNQSSDDE SPTDRVSSSY
SFRNRRQCVE GGVKRELERA TYLDGVLGPI GLSKAAHQAS SPLDAVCLLC GFGSDSSKSK
RNTGVKVYIG GSTLVRNTLI GPFAVSKRYM DMMEQEFPKL FDRMGNEVFM HVGCLAAATN
LVLDSSGHKI ANLLEVLIRG MHDKCAYCGG SSATLHCSGT DCNRAFHYPC SITCAEDEAY
QRQQPTSRRN PSFWSRMNNP VDPLLCDRFL CLECTLKDWI DGSPSVEPLC TGEHFLSDEP
RAWFYSDARD MYPNCYVPQG GDLIFIPLQA RSSIKANSAI PWSSALHTHI LEVKKIDYRF
CGPISGDIGI CSVLWVRQMD NNKRQSLFYR PGDLTVLTLV DVLVGVWRLD KVNVGDSVKV
LCADGWKDAT VSGIKDPLVC SANYNLVSGD FSTANVSRLG RAAIDLGTNC IQAKLVSDSS
EQWYSAWQFR IDPASESSLS DELHQRLFPA EAKEELINLT LDGSFEEFNI LPNWAECDES
WVRTYWSTVA CPMSMEKVRQ RILNSYYMCP QGCLSDLEVI VRNCRFFNPP SSVLCQVAQT
LERAISTTRD EIRRVMNAEK YAKLLIQHLR PFLDRLFVAP SASDHEVVGQ DSITPTQPDS
MSQSQPFDAD VSPASTFGAI SPTQAADCFD DDDMPIRRSA RLLRSRASVS DDIQAHRPPQ
ASTAPLRSEI QEETGDSLGS ESRQISSRED AGSVIRHIGT SSSSRRSSVP SGSTQVQHPD
SGRPTAAGEL QATNRRTSSR LAAISEREAE QAKNAALERQ RQEEEEKLRR TSASRYNLRG
I
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