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Database: UniProt
Entry: A0A061D6W5_BABBI
LinkDB: A0A061D6W5_BABBI
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ID   A0A061D6W5_BABBI        Unreviewed;       199 AA.
AC   A0A061D6W5;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   16-JAN-2019, entry version 18.
DE   RecName: Full=Superoxide dismutase {ECO:0000256|RuleBase:RU000414};
DE            EC=1.15.1.1 {ECO:0000256|RuleBase:RU000414};
GN   ORFNames=BBBOND_0109720 {ECO:0000313|EMBL:CDR94674.1};
OS   Babesia bigemina.
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Babesiidae; Babesia.
OX   NCBI_TaxID=5866 {ECO:0000313|EMBL:CDR94674.1};
RN   [1] {ECO:0000313|EMBL:CDR94674.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bond {ECO:0000313|EMBL:CDR94674.1};
RA   Jackson A.P., Otto T.D., Darby A., Ramaprasad A., Xia D.,
RA   Echaide I.E., Farber M., Gahlot S., Gamble J., Gupta D., Gupta Y.,
RA   Jackson L., Malandrin L., Malas T.B., Moussa E., Nair M., Reid AJ.,
RA   Sanders M., Sharma J., Tracey A., Quail M.A., Weir W., Wastling J.M.,
RA   Hall N., Willadsen P., Lingelbach K., Shiels B., Tait A., Berriman M.,
RA   Allred D.R., Pain A.;
RT   "The evolutionary dynamics of variant antigen genes in Babesia reveal
RT   a history of genomic innovation underlying host-parasite
RT   interaction.";
RL   Nucleic Acids Res. 0:0-0(2014).
RN   [2] {ECO:0000313|EMBL:CDR94674.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bond {ECO:0000313|EMBL:CDR94674.1};
RA   Aslett M., De Silva Nishadi;
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Destroys radicals which are normally produced within the
CC       cells and which are toxic to biological systems.
CC       {ECO:0000256|RuleBase:RU000414}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:18421; EC=1.15.1.1;
CC         Evidence={ECO:0000256|RuleBase:RU000414};
CC   -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase
CC       family. {ECO:0000256|RuleBase:RU000414}.
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DR   EMBL; LK391707; CDR94674.1; -; Genomic_DNA.
DR   RefSeq; XP_012766860.1; XM_012911406.1.
DR   EnsemblProtists; CDR94674; CDR94674; BBBOND_0109720.
DR   GeneID; 24563215; -.
DR   OMA; KWGSFDK; -.
DR   OrthoDB; 1353361at2759; -.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.10.287.990; -; 1.
DR   Gene3D; 2.40.500.20; -; 1.
DR   InterPro; IPR001189; Mn/Fe_SOD.
DR   InterPro; IPR019833; Mn/Fe_SOD_BS.
DR   InterPro; IPR019832; Mn/Fe_SOD_C.
DR   InterPro; IPR019831; Mn/Fe_SOD_N.
DR   InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR   InterPro; IPR036314; SOD_C_sf.
DR   Pfam; PF02777; Sod_Fe_C; 1.
DR   Pfam; PF00081; Sod_Fe_N; 1.
DR   PIRSF; PIRSF000349; SODismutase; 1.
DR   PRINTS; PR01703; MNSODISMTASE.
DR   SUPFAM; SSF46609; SSF46609; 1.
DR   SUPFAM; SSF54719; SSF54719; 1.
DR   PROSITE; PS00088; SOD_MN; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000349-1,
KW   ECO:0000256|RuleBase:RU000414};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000414}.
FT   DOMAIN        3     81       Sod_Fe_N. {ECO:0000259|Pfam:PF00081}.
FT   DOMAIN       89    190       Sod_Fe_C. {ECO:0000259|Pfam:PF02777}.
FT   METAL        27     27       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
FT   METAL        74     74       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
FT   METAL       158    158       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
FT   METAL       162    162       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
SQ   SEQUENCE   199 AA;  22386 MW;  36E4DE0E128DFDAD CRC64;
     MAFKLPALPY GLKDLLPHIS EETLSFHYGK HHAGYVAKLN GLVKGTPLES CSLEELVVGQ
     SGAIFNNAAQ IWNHTFYWNS MGPNCGGEPT GPIRKKIEEK FGSFSAFKQD FSNLLAGHFG
     SGWGWLVLKD DGSTDIVQTH DAGSPLKEKL GRPLLCCDVW EHAYYIDYKN DRASYINSWW
     NLVNWDFANK NLEAPFKWS
//
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