ID   A0A061D7U8_BABBI        Unreviewed;       556 AA.
AC   A0A061D7U8;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=Glucose-6-phosphate isomerase {ECO:0000256|ARBA:ARBA00011952, ECO:0000256|RuleBase:RU000612};
DE            EC=5.3.1.9 {ECO:0000256|ARBA:ARBA00011952, ECO:0000256|RuleBase:RU000612};
GN   ORFNames=BBBOND_0212090 {ECO:0000313|EMBL:CDR96067.1};
OS   Babesia bigemina.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Babesiidae; Babesia.
OX   NCBI_TaxID=5866 {ECO:0000313|EMBL:CDR96067.1, ECO:0000313|Proteomes:UP000033188};
RN   [1] {ECO:0000313|Proteomes:UP000033188}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bond {ECO:0000313|Proteomes:UP000033188};
RA   Aslett M., De Silva N.;
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC         Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC         EC=5.3.1.9; Evidence={ECO:0000256|ARBA:ARBA00029321,
CC         ECO:0000256|RuleBase:RU000612};
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 2/4.
CC       {ECO:0000256|ARBA:ARBA00004926, ECO:0000256|RuleBase:RU000612}.
CC   -!- SIMILARITY: Belongs to the GPI family. {ECO:0000256|ARBA:ARBA00006604,
CC       ECO:0000256|RuleBase:RU000612}.
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DR   EMBL; LK391708; CDR96067.1; -; Genomic_DNA.
DR   RefSeq; XP_012768253.1; XM_012912799.1.
DR   AlphaFoldDB; A0A061D7U8; -.
DR   STRING; 5866.A0A061D7U8; -.
DR   EnsemblProtists; CDR96067; CDR96067; BBBOND_0212090.
DR   GeneID; 24564608; -.
DR   KEGG; bbig:BBBOND_0212090; -.
DR   VEuPathDB; PiroplasmaDB:BBBOND_0212090; -.
DR   OMA; CPAYAYG; -.
DR   OrthoDB; 1657888at2759; -.
DR   UniPathway; UPA00109; UER00181.
DR   Proteomes; UP000033188; Chromosome 2.
DR   GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR   GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05015; SIS_PGI_1; 1.
DR   CDD; cd05016; SIS_PGI_2; 1.
DR   Gene3D; 1.10.1390.10; -; 1.
DR   HAMAP; MF_00473; G6P_isomerase; 1.
DR   InterPro; IPR001672; G6P_Isomerase.
DR   InterPro; IPR023096; G6P_Isomerase_C.
DR   InterPro; IPR018189; Phosphoglucose_isomerase_CS.
DR   InterPro; IPR046348; SIS_dom_sf.
DR   InterPro; IPR035476; SIS_PGI_1.
DR   InterPro; IPR035482; SIS_PGI_2.
DR   PANTHER; PTHR11469; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR   PANTHER; PTHR11469:SF1; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR   Pfam; PF00342; PGI; 1.
DR   PRINTS; PR00662; G6PISOMERASE.
DR   SUPFAM; SSF53697; SIS domain; 1.
DR   PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1.
DR   PROSITE; PS00174; P_GLUCOSE_ISOMERASE_2; 1.
DR   PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
PE   3: Inferred from homology;
KW   Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432,
KW   ECO:0000256|RuleBase:RU000612};
KW   Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU000612};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU000612};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033188}.
SQ   SEQUENCE   556 AA;  60501 MW;  449EEBB0AE8A757C CRC64;
     MLSNKLEESA VFKSLLSSSS AAKNADLAAL LRDRSRCDRL IKSYKGVTLD LSRQLIDSAT
     LDALLSLCHE MNVPKKIEML FSGGILNGTE GRSVLHSALR AARGTSLTVD GSDVVADVYS
     VLDSIKEFSN RVRKGSIVAS DGKPFDSLLC IGIGGSYLGI AFAAQAFMAS SSARRECEGR
     KIRFLANVDP AGFRIATEGL DANRTMVIVI SKTFTTAETM KNAVVARDWL QSNIADPSKF
     GDHLCAISTN LKLTKDFGID DSHVFGFWDW VGGRFSVSSA VGMLPLAIHF GFDIAEQFLS
     GARMMDEHFR QTPLDDNMPV LLALASFYNS TVLGLDCVAL LPYSEDLCLF PRYIQQLCME
     SNGKSVRMNG DKLSYGTGEI YFGESGTNGQ HSFYQLLHQG RVVPSEFIGF IRSDNRDVAE
     NGVTFHEELM ANFFAQPDAL AYGRTPAQLQ AAGCSAHLVA HKACSGNRPS AVMLFEEATP
     YTVGALVALY EHRVAVQGFL WGINSFDQMG VELGKVLASD IRGYFKARHS DWASVEKEGQ
     ISYSTTKLLS LFAGSA
//