ID A0A061DAE2_BABBI Unreviewed; 530 AA.
AC A0A061DAE2;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=GTPase Der {ECO:0000256|ARBA:ARBA00020953, ECO:0000256|RuleBase:RU004481};
GN ORFNames=BBBOND_0400130 {ECO:0000313|EMBL:CDR97518.1};
OS Babesia bigemina.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=5866 {ECO:0000313|EMBL:CDR97518.1, ECO:0000313|Proteomes:UP000033188};
RN [1] {ECO:0000313|Proteomes:UP000033188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bond {ECO:0000313|Proteomes:UP000033188};
RX PubMed=24799432; DOI=10.1093/nar/gku322;
RA Jackson A.P., Otto T.D., Darby A., Ramaprasad A., Xia D., Echaide I.E.,
RA Farber M., Gahlot S., Gamble J., Gupta D., Gupta Y., Jackson L.,
RA Malandrin L., Malas T.B., Moussa E., Nair M., Reid AJ., Sanders M.,
RA Sharma J., Tracey A., Quail M.A., Weir W., Wastling J.M., Hall N.,
RA Willadsen P., Lingelbach K., Shiels B., Tait A., Berriman M., Allred D.R.,
RA Pain A.;
RT "The evolutionary dynamics of variant antigen genes in Babesia reveal a
RT history of genomic innovation underlying host-parasite interaction.";
RL Nucleic Acids Res. 42:7113-7131(2014).
CC -!- FUNCTION: GTPase that plays an essential role in the late steps of
CC ribosome biogenesis. {ECO:0000256|RuleBase:RU004481}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. EngA (Der) GTPase family.
CC {ECO:0000256|ARBA:ARBA00008279, ECO:0000256|RuleBase:RU004481}.
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DR EMBL; LK391710; CDR97518.1; -; Genomic_DNA.
DR RefSeq; XP_012769704.1; XM_012914250.1.
DR AlphaFoldDB; A0A061DAE2; -.
DR STRING; 5866.A0A061DAE2; -.
DR EnsemblProtists; CDR97518; CDR97518; BBBOND_0400130.
DR GeneID; 24566059; -.
DR KEGG; bbig:BBBOND_0400130; -.
DR VEuPathDB; PiroplasmaDB:BBBOND_0400130; -.
DR OMA; MRTDKRT; -.
DR OrthoDB; 211919at2759; -.
DR Proteomes; UP000033188; Chromosome 4.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR CDD; cd01894; EngA1; 1.
DR CDD; cd01895; EngA2; 1.
DR Gene3D; 3.30.300.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_00195; GTPase_Der; 1.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR016484; GTPase_Der.
DR InterPro; IPR032859; KH_dom-like.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR NCBIfam; TIGR03594; GTPase_EngA; 1.
DR NCBIfam; TIGR00231; small_GTP; 2.
DR PANTHER; PTHR43834; GTPASE DER; 1.
DR PANTHER; PTHR43834:SF6; GTPASE DER; 1.
DR Pfam; PF14714; KH_dom-like; 1.
DR Pfam; PF01926; MMR_HSR1; 2.
DR PIRSF; PIRSF006485; GTP-binding_EngA; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU004481};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004481};
KW Reference proteome {ECO:0000313|Proteomes:UP000033188};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU004481};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..530
FT /note="GTPase Der"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001596140"
FT DOMAIN 72..192
FT /note="G"
FT /evidence="ECO:0000259|Pfam:PF01926"
FT DOMAIN 249..364
FT /note="G"
FT /evidence="ECO:0000259|Pfam:PF01926"
FT DOMAIN 424..501
FT /note="GTPase Der C-terminal KH-domain-like"
FT /evidence="ECO:0000259|Pfam:PF14714"
FT REGION 45..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 530 AA; 59196 MW; 53809CC15D4EB8F4 CRC64;
MRFLSISLIV VAHSVVYGFL QPCRECCWAL SGRSASCRRP AVRRAHFQPS GEGEPQLQEP
DDRVDSPCEP VVAIVGRPNV GKSSIFNRIS KQFHRGSIVS ESPGTTRDRQ YALADWEGCT
FRLIDTGGLE DESEYAESIK AQVGDSLDHA SVAIVVVDGQ EGLTEGDLEV RDFVLDALKK
RGNLRVLLCV NKCESFHFGD VLAEQFWRLG LGRPYPVSAL HGTGLGELLN DCVAGFGRCT
IEERHDVVVS FVGRPNCGKS SLVNLLAGSS RCLVSPKEGT TLDTVEVPIV RGEQRYLLID
TAGMRLQSKD RRSFLPKGRS LRAIRRSDVC VLVVDASWGI SRNDVKLAEE IRAESRAAVI
VCNKWDLVDK DPTVYKNAVS YVKEKLHWLD YADVVFTSAK TAQRVSNVLE ACQNAHEQFS
KSFTTALLNE VLREATFLQK PPVTHGKRLN IYYVCQVHSQ PPGIALFCND ERLLTDDYAE
YLEVFFRRSL NLTGSPIRWY PRAKRARHRV PDLRNRASKG SCNPRELLSL
//
