ID A0A061DB61_BABBI Unreviewed; 563 AA.
AC A0A061DB61;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000259|PROSITE:PS50850};
GN ORFNames=BBBOND_0311200 {ECO:0000313|EMBL:CDR97217.1};
OS Babesia bigemina.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=5866 {ECO:0000313|EMBL:CDR97217.1, ECO:0000313|Proteomes:UP000033188};
RN [1] {ECO:0000313|Proteomes:UP000033188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bond {ECO:0000313|Proteomes:UP000033188};
RX PubMed=24799432; DOI=10.1093/nar/gku322;
RA Jackson A.P., Otto T.D., Darby A., Ramaprasad A., Xia D., Echaide I.E.,
RA Farber M., Gahlot S., Gamble J., Gupta D., Gupta Y., Jackson L.,
RA Malandrin L., Malas T.B., Moussa E., Nair M., Reid AJ., Sanders M.,
RA Sharma J., Tracey A., Quail M.A., Weir W., Wastling J.M., Hall N.,
RA Willadsen P., Lingelbach K., Shiels B., Tait A., Berriman M., Allred D.R.,
RA Pain A.;
RT "The evolutionary dynamics of variant antigen genes in Babesia reveal a
RT history of genomic innovation underlying host-parasite interaction.";
RL Nucleic Acids Res. 42:7113-7131(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Spinster (TC
CC 2.A.1.49) family. {ECO:0000256|ARBA:ARBA00024338}.
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DR EMBL; LK391709; CDR97217.1; -; Genomic_DNA.
DR RefSeq; XP_012769403.1; XM_012913949.1.
DR AlphaFoldDB; A0A061DB61; -.
DR EnsemblProtists; CDR97217; CDR97217; BBBOND_0311200.
DR GeneID; 24565758; -.
DR KEGG; bbig:BBBOND_0311200; -.
DR VEuPathDB; PiroplasmaDB:BBBOND_0311200; -.
DR OMA; IVEMDYG; -.
DR OrthoDB; 408765at2759; -.
DR Proteomes; UP000033188; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd06174; MFS; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044770; MFS_spinster-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR23505:SF52; MAJOR FACILITATOR SUPERFAMILY PROTEIN; 1.
DR PANTHER; PTHR23505; SPINSTER; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000033188};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..462
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 514..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..537
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 563 AA; 62178 MW; DAE4E642A8B4CFA9 CRC64;
MSGPQAPSPA SATGELQQAE TAKKIKAEYG TFGQVLYHLV SFTEGYEQQV LYLCMRLFES
TMGFTKQQQT MLMTVSIMSR LCFSLVWGLL ADAFETNLVM SAGLLFMGIA SILLSSTSRF
SSILFLRFLH GAAFGCIYPV QQKIISDEDD DQEGGSSSAF TRIHALNCIG RMLCAAITTE
AAQNILLGFI GWRVSYIVLG YVWISVGIAI VFAMHTDKVV TTPYQSTTDF INRISGAFKA
VFRSWSSFLC IFTMLISEAP MCTLPYMITY LEYLGVSDMK VGIAIVVTTI GGAAGTAAGG
IVIENITKTH KEYGELIAGI VVMGVRLIVC VLFFVSPAPD GRLMWYHYIE FAVLGATLVT
VGGVDRPIMR KVIEDKYQAS ASAIIQCISG ISISVSFVEI FAYVSEKLHG YAPSTQAIDD
MDAALKDNNT EALRKSTMYM IVIGSLLNIA CYGALFATYK KDKETIVPDN KKEWEDRNKR
QEIRDEMKKK KPEEVAILEV PADPETRSRV EVEVKAQGDD EVNMLTELPR PEGRSDDDDE
VLSSDEAVRN YLSTTGRSWE RRG
//
