ID A0A061DD89_BABBI Unreviewed; 520 AA.
AC A0A061DD89;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Dipeptidyl peptidase 1 {ECO:0000256|ARBA:ARBA00014709};
DE EC=3.4.14.1 {ECO:0000256|ARBA:ARBA00012059};
DE AltName: Full=Cathepsin C {ECO:0000256|ARBA:ARBA00029779};
DE AltName: Full=Cathepsin J {ECO:0000256|ARBA:ARBA00029762};
DE AltName: Full=Dipeptidyl peptidase I {ECO:0000256|ARBA:ARBA00032961};
DE AltName: Full=Dipeptidyl transferase {ECO:0000256|ARBA:ARBA00030778};
GN ORFNames=BBBOND_0212020 {ECO:0000313|EMBL:CDR96060.1};
OS Babesia bigemina.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=5866 {ECO:0000313|EMBL:CDR96060.1, ECO:0000313|Proteomes:UP000033188};
RN [1] {ECO:0000313|Proteomes:UP000033188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bond {ECO:0000313|Proteomes:UP000033188};
RA Aslett M., De Silva N.;
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except
CC when Xaa is Arg or Lys, or Yaa or Zaa is Pro.; EC=3.4.14.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000738};
CC -!- COFACTOR:
CC Name=chloride; Xref=ChEBI:CHEBI:17996;
CC Evidence={ECO:0000256|ARBA:ARBA00001923};
CC -!- SUBUNIT: Tetramer of heterotrimers consisting of exclusion domain,
CC heavy- and light chains. {ECO:0000256|ARBA:ARBA00011610}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; LK391708; CDR96060.1; -; Genomic_DNA.
DR RefSeq; XP_012768246.1; XM_012912792.1.
DR AlphaFoldDB; A0A061DD89; -.
DR STRING; 5866.A0A061DD89; -.
DR EnsemblProtists; CDR96060; CDR96060; BBBOND_0212020.
DR GeneID; 24564601; -.
DR KEGG; bbig:BBBOND_0212020; -.
DR VEuPathDB; PiroplasmaDB:BBBOND_0212020; -.
DR OMA; CYIASQM; -.
DR OrthoDB; 5475703at2759; -.
DR Proteomes; UP000033188; Chromosome 2.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0008239; F:dipeptidyl-peptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 2.40.128.80; Cathepsin C, exclusion domain; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR014882; CathepsinC_exc.
DR InterPro; IPR036496; CathepsinC_exc_dom_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR PANTHER; PTHR12411:SF947; CATHEPSIN O; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08773; CathepsinC_exc; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF75001; Dipeptidyl peptidase I (cathepsin C), exclusion domain; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000033188};
KW Signal {ECO:0000256|SAM:SignalP}; Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..520
FT /note="Dipeptidyl peptidase 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018594735"
FT DOMAIN 251..498
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 520 AA; 58258 MW; A9BBB42BCE4D1A3F CRC64;
MLPLLCLIHL LASVVQVRAD LPIHALVTDI SGKWRIFQSR AVGGLDVACG SDVPNSPEGN
LLLGNYLAYL KTHFCLDRTT DVHLSLDVTA YSDNTNAPNR SMWRALAVKD KRGNVVGRWT
AVSDQGFEII FHNNARYFFY LHYTKRDGDQ YETDVTKTQI GWVYEPQGSS DAHATRRCAY
AARVDGTKPR VSTIVQLKSN DVKNKYRQIS RFISHDTGGV LSAASNKISP KKGPYPCDCS
SRNQLDFDDD VPESFVWHTQ ATIPVVNQQQ CGSCYAIATK YVLHARFLIA LERCGERTPE
QEKALEELSH NYFYPEDTSD CSMFNQGCKG GYPYLMGKQM HELGISVVKG NAQQCAILSA
ERRYFAKDYG YVSGCSQCTA CQGEELIMRE IYANGPVVTA VDAAILNTEY DGSVISPVDS
EHNSGVCDVE QHPILTGWEY TSHAVAIVGW GQQLEQGKMV KYWLCRNSWG PEWGEDGYFK
IERGKNVFGV ESEAVFVDPD LSRFKQAPAD ARLHDIHYHY
//
