ID A0A061EQZ2_THECC Unreviewed; 1155 AA.
AC A0A061EQZ2;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=BREAST CANCER 2 like 2A, putative isoform 1 {ECO:0000313|EMBL:EOY07083.1};
GN ORFNames=TCM_021601 {ECO:0000313|EMBL:EOY07083.1};
OS Theobroma cacao (Cacao) (Cocoa).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Byttnerioideae; Theobroma.
OX NCBI_TaxID=3641 {ECO:0000313|EMBL:EOY07083.1, ECO:0000313|Proteomes:UP000026915};
RN [1] {ECO:0000313|EMBL:EOY07083.1, ECO:0000313|Proteomes:UP000026915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Matina 1-6 {ECO:0000313|Proteomes:UP000026915};
RX PubMed=23731509; DOI=10.1186/gb-2013-14-6-r53;
RA Motamayor J.C., Mockaitis K., Schmutz J., Haiminen N., Iii D.L.,
RA Cornejo O., Findley S.D., Zheng P., Utro F., Royaert S., Saski C.,
RA Jenkins J., Podicheti R., Zhao M., Scheffler B.E., Stack J.C., Feltus F.A.,
RA Mustiga G.M., Amores F., Phillips W., Marelli J.P., May G.D., Shapiro H.,
RA Ma J., Bustamante C.D., Schnell R.J., Main D., Gilbert D., Parida L.,
RA Kuhn D.N.;
RT "The genome sequence of the most widely cultivated cacao type and its use
RT to identify candidate genes regulating pod color.";
RL Genome Biol. 14:R53.1-R53.24(2013).
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DR EMBL; CM001883; EOY07083.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A061EQZ2; -.
DR STRING; 3641.A0A061EQZ2; -.
DR EnsemblPlants; EOY07083; EOY07083; TCM_021601.
DR Gramene; EOY07083; EOY07083; TCM_021601.
DR eggNOG; KOG4751; Eukaryota.
DR InParanoid; A0A061EQZ2; -.
DR OMA; GLCKHAG; -.
DR Proteomes; UP000026915; Chromosome 5.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd04493; BRCA2DBD_OB1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015252; BRCA2_hlx.
DR InterPro; IPR036315; BRCA2_hlx_sf.
DR InterPro; IPR015187; BRCA2_OB_1.
DR InterPro; IPR002093; BRCA2_repeat.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09169; BRCA-2_helical; 1.
DR Pfam; PF09103; BRCA-2_OB1; 1.
DR Pfam; PF00634; BRCA2; 3.
DR SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR PROSITE; PS50138; BRCA2_REPEAT; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000026915};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 544..616
FT /note="Breast cancer type 2 susceptibility protein helical"
FT /evidence="ECO:0000259|Pfam:PF09169"
FT DOMAIN 620..756
FT /note="BRCA2 OB1"
FT /evidence="ECO:0000259|Pfam:PF09103"
FT REGION 232..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1155 AA; 127187 MW; 5CDD55C34E3F6B68 CRC64;
MSTWQIFSDA GNDFRWEVSG RILPSKPDDE PNRAPVPPLP SMADLLLQGC SKLIENGDAG
VRNCPMFRTG LGKSVALKES SIAKALSILG DDDVGTAVTS SKRFSLSLFS FNNVHLAFHI
LILSFIWEVV PGNNGFGCSN SLFQTGSGKM VNISSAGLVR AKTLLGLEQD NEHHSFEGFQ
HPKKLPATNE PCGWQSFSHS EKKEGLRNTG VADFFSESRH LLNSRNGFVG STVGSENDST
PVHSKEFDSA PKPPPIKFHT AGGRSLSVSS DALKRARSLL GDPELGNFFG EVEEEVPPFT
VSEEKFNDAS SNKENHFFTS FSLQGTIKSK DTSKDFISPL KASFKQMRSI FNSEKICCGS
NLIDKFDAVG KFDAVGNSNA CVSTTNMPSA QKPLSNSTSE KNLVTNISLP RLGKSFGGPL
ADISNNIVTS QTNNKRIMTE KKRIGRSSFI SPYKRPRCSE FSTPLNKGVS FVGNALSASS
DDHSCCKRTV STKYPFQVPR VYMKEYFAVP PSACSMLECL SDQEKQIKPD NAIKYMFKDE
SGLSRIGAEA FYDMLAHSGA SMQYICKEWV ANHYKWIVWK LVCYERCYPS KCAGKFLTIS
NVLEELKYRY DREVNHAHRS AIKRILEGDA SPSTMLVLCI SNIQSNSEPK METNLLITNG
ADNSGNAKVE LTDGWYSMDA VLDVLLSKQL AAGKLFVGQK LRIWGAGLCG WVGPVSPLEV
LADLKFFKEA SSAISLLLNI NGTFRAHWAD RLGFCKGVGT PLAFRCIKSD GGPVPWTLVG
VTRIYPVLYR ERLSNGGSIV RSERMESRMV QQHNQRGSVV VDHVISEYQR GVNSSHILSD
SESEGAKILK ILETAAEPEV LMAEMSPEQL TSFATYKSKL EATRQLEMEK SIKKALAEAG
LNERDVVPFI RVRVVGLTTR KYHGKGRPKE GIITIWNPTE KQKSELVEGQ AYVVAGLIPI
YSDSEALYLQ ARGSTTKWQP LSPMAMECFE PFFSPRKPTK LSNLGEIPLS SEFDIAVYVV
YVGEVYTAAH QKKQWVFVTD DSISNLLSEG LSDSLLAISF CSPCIDKDSF APINSNLVGS
MVGFCNLIKK AKDQMNHLWV AEAAENCAYF LNLNPSICSH LKIAGACVQT WAKASNSIID
KLREKVLFIL DNCGG
//
