ID A0A061FLB0_THECC Unreviewed; 1235 AA.
AC A0A061FLB0;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Hedgehog receptor, putative isoform 11 {ECO:0000313|EMBL:EOY15274.1};
GN ORFNames=TCM_034394 {ECO:0000313|EMBL:EOY15274.1};
OS Theobroma cacao (Cacao) (Cocoa).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Byttnerioideae; Theobroma.
OX NCBI_TaxID=3641 {ECO:0000313|EMBL:EOY15274.1, ECO:0000313|Proteomes:UP000026915};
RN [1] {ECO:0000313|EMBL:EOY15274.1, ECO:0000313|Proteomes:UP000026915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Matina 1-6 {ECO:0000313|Proteomes:UP000026915};
RX PubMed=23731509; DOI=10.1186/gb-2013-14-6-r53;
RA Motamayor J.C., Mockaitis K., Schmutz J., Haiminen N., Iii D.L.,
RA Cornejo O., Findley S.D., Zheng P., Utro F., Royaert S., Saski C.,
RA Jenkins J., Podicheti R., Zhao M., Scheffler B.E., Stack J.C., Feltus F.A.,
RA Mustiga G.M., Amores F., Phillips W., Marelli J.P., May G.D., Shapiro H.,
RA Ma J., Bustamante C.D., Schnell R.J., Main D., Gilbert D., Parida L.,
RA Kuhn D.N.;
RT "The genome sequence of the most widely cultivated cacao type and its use
RT to identify candidate genes regulating pod color.";
RL Genome Biol. 14:R53.1-R53.24(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; CM001886; EOY15274.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A061FLB0; -.
DR EnsemblPlants; EOY15274; EOY15274; TCM_034394.
DR Gramene; EOY15274; EOY15274; TCM_034394.
DR Proteomes; UP000026915; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0015918; P:sterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:EOY15274.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000026915};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..1235
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001598138"
FT TRANSMEM 286..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 657..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 687..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 732..754
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 760..786
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 835..858
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1111..1134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1141..1163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1169..1191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 623..786
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1235 AA; 136219 MW; 66B56EF36614CF06 CRC64;
MDVSRRRMGL PLLFLSSISL FQVLFIVPVV VAQTTNNELR QRHSEGYCAM YDICGNRSDG
KVLNCPYGSP AVKPDELLSS KIQSLCPTIT ENVCCTEAQF DTLRTQVQQA IPFLVGCPAC
LRNFLNLFCE LSCSPNQSLF INVTSVSKVK NNLTVDGIDF YITDAFGEGL YESCKDVKFG
TMNMRALELI GSGAKNFKEW FAFIGKQAEP DLPGSPYAIQ FQPTAPESLG MRPMNVSTYS
CGDVSLGCSC GDCPSSPVCS NTAPPPHEGD KCSVRIGSLK AKCVDLALAI LYIVLVSMFF
GWGLFHRTRK RRSFRMKPFL NTADGGESSV NMQKAENLPM QRLDDANQNS SGVQLSIVQG
YMSNFYRKYG RWVARNPTLV LSLSVGMVLL LCLGLIHFKV ETRPEKLWVG PGSKAAEEKR
FFDSHLAPFY RIEQLILATI PDALHDKSPS IVTEENIKLL FEIQKKIDAI RANYSGSMIT
LTDICMKPMG QDCATQSVMQ YFKMDPSYNA DDRLEHVKYC FQHYTSAESC MSAFKAPLDP
STILGGFSGT NYTEASAFII TYPVNNAIDK EGNETEKAVA WEKAFIRLAK DELLPMVQSK
NLTFSFSSES SIEEELKRES TADVITILIS YLVMFAYISL TLGDTPRLPS FYITSKVLLG
LAGVLLVMLS VLGSVGFFSA IGVKSTLIIM EVIPFLVLAV GVDNMCILVH AVKRQALDLP
LEGRISNALV EVGPSITLAS LSEVLAFAVG SFIPMPACRV FSMFAALAVL LDFLLQVTAF
VSLIVFDFLR ADSRRIDCFP CIKVSSTYAE SEKGIGGRKP GLLARYMKEV HAPILNLWGV
KIIVVSTFVA FALASIALST RIEPGLEQKI VLPQDSYLQG YFNNVSDYLR IGPPLYFVVK
NYNYSSESID TNQLCSISQC NSDSLLNEIA RASLTPELSY IAKPAASWLD DFLVWISPEA
FGCCRKFTNG TYCPPDDQPP CCSAGDSSCG LSEVCKDCTT CFRHSDLHND RPSTAQFKEK
LPWFLDALPS ADCSKGGHGA YTSSVELKGY ENGVIRASSF RTYHTPLNKQ IDYVNSMRAA
REFASRVSGS LKMEIFPYSV FYMFFEQYLD IWRTALINLA IAIGAVFIVC LVITCSLWSS
AIILLVLAMI VVDLMGVMAI LGIQLNAVSV VNLVMAVGIA VEFCVHITHV FSVSSGNKDE
RVKEALGTMG ASVFRFFCFS YEPHPTPFPL CRGDK
//
