ID A0A061FW56_THECC Unreviewed; 532 AA.
AC A0A061FW56;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=isochorismate synthase {ECO:0000256|ARBA:ARBA00012824};
DE EC=5.4.4.2 {ECO:0000256|ARBA:ARBA00012824};
GN ORFNames=TCM_013842 {ECO:0000313|EMBL:EOY21735.1};
OS Theobroma cacao (Cacao) (Cocoa).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Byttnerioideae; Theobroma.
OX NCBI_TaxID=3641 {ECO:0000313|EMBL:EOY21735.1, ECO:0000313|Proteomes:UP000026915};
RN [1] {ECO:0000313|EMBL:EOY21735.1, ECO:0000313|Proteomes:UP000026915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Matina 1-6 {ECO:0000313|Proteomes:UP000026915};
RX PubMed=23731509; DOI=10.1186/gb-2013-14-6-r53;
RA Motamayor J.C., Mockaitis K., Schmutz J., Haiminen N., Iii D.L.,
RA Cornejo O., Findley S.D., Zheng P., Utro F., Royaert S., Saski C.,
RA Jenkins J., Podicheti R., Zhao M., Scheffler B.E., Stack J.C., Feltus F.A.,
RA Mustiga G.M., Amores F., Phillips W., Marelli J.P., May G.D., Shapiro H.,
RA Ma J., Bustamante C.D., Schnell R.J., Main D., Gilbert D., Parida L.,
RA Kuhn D.N.;
RT "The genome sequence of the most widely cultivated cacao type and its use
RT to identify candidate genes regulating pod color.";
RL Genome Biol. 14:R53.1-R53.24(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985,
CC ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000799};
CC -!- SIMILARITY: Belongs to the isochorismate synthase family.
CC {ECO:0000256|ARBA:ARBA00005297}.
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DR EMBL; CM001881; EOY21735.1; -; Genomic_DNA.
DR EMBL; CM001881; EOY21736.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A061FW56; -.
DR EnsemblPlants; EOY21735; EOY21735; TCM_013842.
DR EnsemblPlants; EOY21736; EOY21736; TCM_013842.
DR Gramene; EOY21735; EOY21735; TCM_013842.
DR Gramene; EOY21736; EOY21736; TCM_013842.
DR Proteomes; UP000026915; Chromosome 3.
DR GO; GO:0008909; F:isochorismate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR004561; IsoChor_synthase.
DR InterPro; IPR044250; MenF-like.
DR NCBIfam; TIGR00543; isochor_syn; 1.
DR PANTHER; PTHR47253; -; 1.
DR PANTHER; PTHR47253:SF4; ISOCHORISMATE SYNTHASE 2, CHLOROPLASTIC; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000026915}.
FT DOMAIN 290..518
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
SQ SEQUENCE 532 AA; 59340 MW; 3C0E974620FB3B9D CRC64;
MAATGAGRHY VARFVDSELT KCTLSYSQHS SCRQSIQVFH NKFQVCTLSM NGCQGDPKLP
VGTIETRTLA AVPSPDLAMD RLNLAIGDLK YSPPPFSSGI IRLQVPIQQR IEAIEWLHAQ
NQILPRCFFS GRRSRANGAN LLVDMTNGNG HNSFGQNLLS VAGVGSAVFF RQLHPFSYDD
WRSITRFLSL KCPLIRAYGA IRFDARANIS REWEAFGSFY FTVPQVEFDE LEGSSILAVT
VAWDNALSWT WDEAIDSLEA TTHQVASVVV MLRKEASGEL ILSNNHVPNK THWDLAVKRA
LQTINRSSSP LIKVVLARSS RVLTATDIDP ITWLACLQVE GENAYQFCLQ PPNAPAFIGN
TPEQLFHRKW LSISSEAMAG TRARGGSRTL DLQIEHDLLS SPKDHLEFTI VRESIQNKLE
SVCDRVVVEP KKTVRKLRRI QHLFAQLAGN LKREDDEFEI LSYLHPTPAV CGFPTETARL
FISETEMFDR GMYAGPVGWF GGGESEFAVG IRSALVEKVS TKASLKLHNI LY
//
