ID A0A061G245_THECC Unreviewed; 559 AA.
AC A0A061G245;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=mRNA m(6)A methyltransferase {ECO:0000256|ARBA:ARBA00012160};
DE EC=2.1.1.348 {ECO:0000256|ARBA:ARBA00012160};
DE Flags: Fragment;
GN ORFNames=TCM_015668 {ECO:0000313|EMBL:EOY23925.1};
OS Theobroma cacao (Cacao) (Cocoa).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Byttnerioideae; Theobroma.
OX NCBI_TaxID=3641 {ECO:0000313|EMBL:EOY23925.1, ECO:0000313|Proteomes:UP000026915};
RN [1] {ECO:0000313|EMBL:EOY23925.1, ECO:0000313|Proteomes:UP000026915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Matina 1-6 {ECO:0000313|Proteomes:UP000026915};
RX PubMed=23731509; DOI=10.1186/gb-2013-14-6-r53;
RA Motamayor J.C., Mockaitis K., Schmutz J., Haiminen N., Iii D.L.,
RA Cornejo O., Findley S.D., Zheng P., Utro F., Royaert S., Saski C.,
RA Jenkins J., Podicheti R., Zhao M., Scheffler B.E., Stack J.C., Feltus F.A.,
RA Mustiga G.M., Amores F., Phillips W., Marelli J.P., May G.D., Shapiro H.,
RA Ma J., Bustamante C.D., Schnell R.J., Main D., Gilbert D., Parida L.,
RA Kuhn D.N.;
RT "The genome sequence of the most widely cultivated cacao type and its use
RT to identify candidate genes regulating pod color.";
RL Genome Biol. 14:R53.1-R53.24(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-
CC methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:55584, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=2.1.1.348;
CC Evidence={ECO:0000256|ARBA:ARBA00036277};
CC -!- SIMILARITY: Belongs to the MT-A70-like family. {ECO:0000256|PROSITE-
CC ProRule:PRU00489}.
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DR EMBL; CM001881; EOY23925.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A061G245; -.
DR EnsemblPlants; EOY23925; EOY23925; TCM_015668.
DR Gramene; EOY23925; EOY23925; TCM_015668.
DR Proteomes; UP000026915; Chromosome 3.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0090304; P:nucleic acid metabolic process; IEA:UniProt.
DR InterPro; IPR007757; MT-A70-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12829; N6-ADENOSINE-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR12829:SF2; N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF05063; MT-A70; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51143; MT_A70; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EOY23925.1}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000026915};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 71..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..92
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 559
FT /evidence="ECO:0000313|EMBL:EOY23925.1"
SQ SEQUENCE 559 AA; 62441 MW; 35F4FFCBBC044BBA CRC64;
METHTGGGTN NEGTIATIKS IRTQLESRIQ TQHATHLDLL ASLQSLDANI VPSLDLSLRI
VSAFNHRPFS PTPPLPTPKK ISHPPQHPPT HPVTDPKQLA LVKPDQGDKP ADEKGNPLSV
VRAIVAECLL QRVPFKAIDS STVLRKLEND ENVTAAEKAA MRELGGDSGS ILAVEMALRS
MAEDNGGLEV EEFVVGGKSR VMILNIDRTR LVRELPEEPQ NHLKRERINT VNESESLKIN
NNSNDEWVAP RPMSEIWMGG GDPGMMYPPG VPMAGPRGRG MGMMGRPPMG PNSGLSPAQR
QRTEEDDLKD LEALLNKKSF KEMQKSKTGE EILDIINRPT ARETAVAAKF KSKGGSQVRE
YCSALTKEDC RRQSGTFLAC KKVHFKRIIA PHTDISLGDC SFLDTCRHMK TDGLIFLWVT
GRAMELGREC LELWGYKRCE EIIWVKTNQL QRIIRTGRTG HWLNHSKEHC LVGIKGNPEI
NRNIDTDVIV AEVRETSRKP DEMYPMLERI SPRTRKLELF ARMHNTQAGW ISLGNQLNGV
RLVDEGLRAR YKAAYPHLD
//
