ID A0A061HEN3_BLUGR Unreviewed; 1120 AA.
AC A0A061HEN3;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Bgt-5131 {ECO:0000313|EMBL:SUZ11890.1};
DE SubName: Full=Membrane bound guanine nucleotide exchange factor {ECO:0000313|EMBL:EPQ63365.1};
GN ORFNames=BGT96224_5131 {ECO:0000313|EMBL:EPQ63365.1},
GN BGT96224V2_LOCUS5064 {ECO:0000313|EMBL:SUZ11890.1};
OS Blumeria graminis f. sp. tritici 96224.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Erysiphales; Erysiphaceae; Blumeria.
OX NCBI_TaxID=1268274 {ECO:0000313|EMBL:SUZ11890.1};
RN [1] {ECO:0000313|Proteomes:UP000053110}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=96224 {ECO:0000313|Proteomes:UP000053110};
RX PubMed=23852167; DOI=10.1038/ng.2704;
RA Wicker T., Oberhaensli S., Parlange F., Buchmann J.P., Shatalina M.,
RA Roffler S., Ben-David R., Dolezel J., Simkova H., Schulze-Lefert P.,
RA Spanu P.D., Bruggmann R., Amselem J., Quesneville H.,
RA Ver Loren van Themaat E., Paape T., Shimizu K.K., Keller B.;
RT "The wheat powdery mildew genome shows the unique evolution of an obligate
RT biotroph.";
RL Nat. Genet. 45:1092-1096(2013).
RN [2] {ECO:0000313|EMBL:EPQ63365.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=96224 {ECO:0000313|EMBL:EPQ63365.1};
RA Oberhaensli S., Wicker T., Keller B.;
RT "The wheat powdery mildew genome reveals unique evolution of an obligate
RT biotroph.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:SUZ11890.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=96224 {ECO:0000313|EMBL:SUZ11890.1};
RA Quirk P.G., Krulwich T.A.;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE375125; EPQ63365.1; -; Genomic_DNA.
DR EMBL; UIGY01000153; SUZ11890.1; -; Genomic_DNA.
DR HOGENOM; CLU_002632_0_0_1; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000053110; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001202; WW_dom.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000053110};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 10..69
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 702..835
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 871..1108
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 74..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..109
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1120 AA; 126727 MW; 9EC51EC02687994D CRC64;
MNGFLGNAPL PVMYVRALYD YETDDRTSLS FHEGDIIQVI TQLESGWWDG VIEGVRGWFP
SNYCQVLQNP KEAFDHKSNE SPETDGEADE TEGSEASEEY EDHYEDEEAQ SEREDLAHVP
SEVDSIDKDR QRADFWIPQA TPDGRLFYFN TETGESSSEL PLETPLLSEI SPRDRVKINN
MPEKTKPPTE LMARGYVHDE NDESDGNSSV DHGEISMIGH SNSYSRQHSL ITTGISSSSS
IDSIHEIIPS SRSRRDLSVP NVTCSSSSSF LSTPSLKAPQ TNSLSRSFFD DGNIAPLTWN
RLVANMKIAV DRYQDAINNY ERSEYVRRAE DISDHLRMLL AAGSGTTDNH SGQPSIISSN
KALYPHFRDM MSKFSKLVIS SHIAAADWPN AESYQKCLQE ADGVLQGVFC YVEVARQQRG
EDIPRLFPGF VMGNASLIDR LDELQLILLS QVRKLEESTD ITDKIITPSR HEAIGNRICS
AAMEVLETFK PWVLTIESID LTLLKNSFEN PQLMDFACLK QGLYDNVSDL IISCQAVTSP
IGDEWAEAKE ESLSERLTHV RLCAKLLGTK ASQVGYSLQL IGELVQTAQS LPPRDDSRLQ
ESIRTGNSSY GRSQHTRSES RINPVLRPVI SSLTQPFGEG DPSANYPKGE NSKVRKFFGE
EPTRRDPVIA ARTDQSPSHV DEVPDCLKLD FEEDIAYDLK AQPPQLKGGT LMALVEQLTR
HDKLDSNFNN TFLLTYRSFT TARELFTLLV QRFQIQPPEG LSISDYEVWR DRKLRPIRFR
VVNILKSWFD NFWMEDQSEE TKALIREVYT FARDTVKTTE TPGSTPLMSV LEKRLRGQDT
TAKRLVLTLS QSTPAPIMPK NMKKLKFLDI DVTEFARQLT IVESKLYGKI KPTECLNKTW
QKKVAEGEPE PAPNVKALIL HSNQLTNWVA EIILTQLDVK KRVVVIKHFV LVADKCRQLN
NYSTLTSIIS ALGTAPIHRL KRTWDQVPAK TIAILESMRR LMGSTKNFGE YRESLHLANP
PCIPFFGVYL TDLTFIEDGI PSIIKKSTLI NFAKRAKTAE VIRDIQQYQN AQYPLQSVPE
LQEYILSNMQ AASDVHEMYE RSLAVEPRER EDEKIVRYVS
//
