ID A0A061ITH0_TRYRA Unreviewed; 525 AA.
AC A0A061ITH0;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
GN ORFNames=TRSC58_06471 {ECO:0000313|EMBL:ESL05864.1};
OS Trypanosoma rangeli SC58.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX NCBI_TaxID=429131 {ECO:0000313|EMBL:ESL05864.1, ECO:0000313|Proteomes:UP000031737};
RN [1] {ECO:0000313|EMBL:ESL05864.1, ECO:0000313|Proteomes:UP000031737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC58 {ECO:0000313|EMBL:ESL05864.1,
RC ECO:0000313|Proteomes:UP000031737};
RA Stoco P.H., Wagner G., Gerber A., Zaha A., Thompson C., Bartholomeu D.C.,
RA Luckemeyer D.D., Bahia D., Loreto E., Prestes E.B., Lima F.M.,
RA Rodrigues-Luiz G., Vallejo G.A., Filho J.F., Monteiro K.M., Tyler K.M.,
RA de Almeida L.G., Ortiz M.F., Siervo M.A., de Moraes M.H., Cunha O.L.,
RA Mendonca-Neto R., Silva R., Teixeira S.M., Murta S.M., Sincero T.C.,
RA Mendes T.A., Urmenyi T.P., Silva V.G., da Rocha W.D., Andersson B.,
RA Romanha A.J., Steindel M., de Vasconcelos A.T., Grisard E.C.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESL05864.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AUPL01006471; ESL05864.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A061ITH0; -.
DR EnsemblProtists; ESL05864; ESL05864; TRSC58_06471.
DR VEuPathDB; TriTrypDB:TRSC58_06471; -.
DR OrthoDB; 66776at2759; -.
DR Proteomes; UP000031737; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR028081; Leu-bd.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR Pfam; PF13458; Peripla_BP_6; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
PE 3: Inferred from homology;
KW Receptor {ECO:0000313|EMBL:ESL05864.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..46
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 47..525
FT /note="adenylate cyclase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001605632"
FT DOMAIN 107..402
FT /note="Leucine-binding protein"
FT /evidence="ECO:0000259|Pfam:PF13458"
SQ SEQUENCE 525 AA; 56604 MW; 35DE7F6259F663FF CRC64;
MAVRWERGGG CAQLGLRPSA APSRLAVVSL LLLLLLLLLF APQSAASKSA VSKTHVKVLL
VRGSDIAVPN AVLTAFYTGV DASLWAHNSA AAGDVCVEVV RREAKMSEFV AVLEGAVQKE
NGTLALLGQF GDTYLKAALP VLPRFDLVAF APFTASSAVR GWNPNVYFVR PDPVAELLAL
IRHAVTELRV LRVGFMYLRG VFFGDGECEQ AGRVMSEMGY ELSGVFTVDS DAGGGADPKE
FDAAWERFAA ARPQAVIVFG SPVRDTKKFV RRMLTDGRTA GAYLLAPSVV QSVVVRTWRA
VVAAGGAEFV PGQVISTGTT PLAKDTQYGA IRRFQGVMRD YLANGGQTDY NDTEHFLKND
SDGELMVDGW VAGEVLAQAL SNRKWVSDRK AFMASLFNQR RYVVDDLVIG DYGGECKGAA
ASRGATCRCN GGGRTVYMKR FVEGYRAEAV GEGLMTFRLS DCNVSSTLVP PVFSGVALLM
ADGGAAHRAF GEIWVPGLVL CLLRRHVRRG RNVVSISLFF SFHRP
//
