ID A0A061IV48_TRYRA Unreviewed; 370 AA.
AC A0A061IV48;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=RNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012724};
DE EC=6.5.1.3 {ECO:0000256|ARBA:ARBA00012724};
GN ORFNames=TRSC58_06587 {ECO:0000313|EMBL:ESL05751.1};
OS Trypanosoma rangeli SC58.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX NCBI_TaxID=429131 {ECO:0000313|EMBL:ESL05751.1, ECO:0000313|Proteomes:UP000031737};
RN [1] {ECO:0000313|EMBL:ESL05751.1, ECO:0000313|Proteomes:UP000031737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC58 {ECO:0000313|EMBL:ESL05751.1,
RC ECO:0000313|Proteomes:UP000031737};
RA Stoco P.H., Wagner G., Gerber A., Zaha A., Thompson C., Bartholomeu D.C.,
RA Luckemeyer D.D., Bahia D., Loreto E., Prestes E.B., Lima F.M.,
RA Rodrigues-Luiz G., Vallejo G.A., Filho J.F., Monteiro K.M., Tyler K.M.,
RA de Almeida L.G., Ortiz M.F., Siervo M.A., de Moraes M.H., Cunha O.L.,
RA Mendonca-Neto R., Silva R., Teixeira S.M., Murta S.M., Sincero T.C.,
RA Mendes T.A., Urmenyi T.P., Silva V.G., da Rocha W.D., Andersson B.,
RA Romanha A.J., Steindel M., de Vasconcelos A.T., Grisard E.C.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.;
CC EC=6.5.1.3; Evidence={ECO:0000256|ARBA:ARBA00034038};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESL05751.1}.
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DR EMBL; AUPL01006587; ESL05751.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A061IV48; -.
DR EnsemblProtists; ESL05751; ESL05751; TRSC58_06587.
DR VEuPathDB; TriTrypDB:TRSC58_06587; -.
DR OrthoDB; 166878at2759; -.
DR Proteomes; UP000031737; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003972; F:RNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.30.1490.70; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 1.10.10.1810; RNA ligase; 1.
DR InterPro; IPR012647; RNA_lig_RNL2.
DR InterPro; IPR021122; RNA_ligase_dom_REL/Rnl2.
DR InterPro; IPR041948; Rnl1/2_C_sf.
DR NCBIfam; TIGR02307; RNA_lig_RNL2; 1.
DR Pfam; PF09414; RNA_ligase; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ESL05751.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000031737}.
FT DOMAIN 4..223
FT /note="RNA ligase"
FT /evidence="ECO:0000259|Pfam:PF09414"
SQ SEQUENCE 370 AA; 41945 MW; 947B7A53A0CE1A39 CRC64;
MFDDEWIATE KVHGANFGIY SIDGGKMIRY AKRSGIMLPT EHFFGYHILI PQLQQYITAT
REMLCDKLQR KLHTVLINGE LFGGKYDHPS LPKTRKTVMV AGKPRTISAV QTDSFPQYSP
DLHFYAFDIK YKEGADAEYT TLMFDEATEL FQKIPGLLYA RAIIRGPMSK VAAFDVEHFV
TTIPPLVGMG NYPLKGNWAE GLVVKHAKRG MPGFDPKGLT ILKFKCTAFQ EISTDRRQGP
RVDEMEVVRR DSISRSGVQL PDMESVIHDP VQLDASKFLL DHICENRLNA VLSKIGTDPF
EKEEMTPDAL ATLLAKDALK DFLKEAEPAI VNTPILTRRD MARYVLFESR RLVCSRWKTI
LQRQTPDVVG
//
