ID A0A061IW12_TRYRA Unreviewed; 466 AA.
AC A0A061IW12;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Cysteine peptidase B {ECO:0000313|EMBL:ESL06275.1};
GN ORFNames=TRSC58_06053 {ECO:0000313|EMBL:ESL06275.1};
OS Trypanosoma rangeli SC58.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX NCBI_TaxID=429131 {ECO:0000313|EMBL:ESL06275.1, ECO:0000313|Proteomes:UP000031737};
RN [1] {ECO:0000313|EMBL:ESL06275.1, ECO:0000313|Proteomes:UP000031737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC58 {ECO:0000313|EMBL:ESL06275.1,
RC ECO:0000313|Proteomes:UP000031737};
RA Stoco P.H., Wagner G., Gerber A., Zaha A., Thompson C., Bartholomeu D.C.,
RA Luckemeyer D.D., Bahia D., Loreto E., Prestes E.B., Lima F.M.,
RA Rodrigues-Luiz G., Vallejo G.A., Filho J.F., Monteiro K.M., Tyler K.M.,
RA de Almeida L.G., Ortiz M.F., Siervo M.A., de Moraes M.H., Cunha O.L.,
RA Mendonca-Neto R., Silva R., Teixeira S.M., Murta S.M., Sincero T.C.,
RA Mendes T.A., Urmenyi T.P., Silva V.G., da Rocha W.D., Andersson B.,
RA Romanha A.J., Steindel M., de Vasconcelos A.T., Grisard E.C.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESL06275.1}.
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DR EMBL; AUPL01006053; ESL06275.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A061IW12; -.
DR EnsemblProtists; ESL06275; ESL06275; TRSC58_06053.
DR VEuPathDB; TriTrypDB:TRSC58_06053; -.
DR OrthoDB; 5485574at2759; -.
DR Proteomes; UP000031737; Unassembled WGS sequence.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 1.10.287.2250; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR021981; DUF3586.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF947; CATHEPSIN O; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF12131; DUF3586; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000031737};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..466
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018646321"
FT DOMAIN 38..94
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 123..335
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 466 AA; 49135 MW; 1D0DFDD9AF7D0140 CRC64;
MTGPARTLSL VAVLVVVLCL LPAAMASLRV EETLASQFAA FKQRHGKVYG SAAEEAFRLG
VFKENLLFAR LHAAANPHAS FGVTPFSDLT REEFRSRYHN AAAHFAAAQK RVRVPVEVEV
GGAPAAVDWR ARGAVTAVKD QGNCGSCWAF STIGNIEGQW HLAGNPLTGL SEQMLVSCDN
ADDGCDGGLM DSAFDWIVGQ NNGSVYTEAS YSYVSGGGDS QTCSMSSHVV GAVISGHVDL
PQDEDKMAAW LAVNGPLAIA VDATSFMSYT GGVLTNCVSD QLDHGVVLVG YNDSSNPPYW
IIKNSWGADW GEEGYIRIQK GTNQCLVNSY ACSAVVGGPA PTPNPSTTTT TTSAPGPSLL
VQQLCSGPGC TTGCVNSSFP TGQCVQAFGR VSAILTCDAT SAVEKLFPLS TDCTGPSLPV
SVPLNKCLSF FIGSVEFFCV SSATARPIEV DKLSRYQPYQ GSHRRL
//
