ID   A0A061IW62_TRYRA        Unreviewed;       608 AA.
AC   A0A061IW62;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Methyltransferase {ECO:0000313|EMBL:ESL06919.1};
GN   ORFNames=TRSC58_05399 {ECO:0000313|EMBL:ESL06919.1};
OS   Trypanosoma rangeli SC58.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX   NCBI_TaxID=429131 {ECO:0000313|EMBL:ESL06919.1, ECO:0000313|Proteomes:UP000031737};
RN   [1] {ECO:0000313|EMBL:ESL06919.1, ECO:0000313|Proteomes:UP000031737}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC58 {ECO:0000313|EMBL:ESL06919.1,
RC   ECO:0000313|Proteomes:UP000031737};
RA   Stoco P.H., Wagner G., Gerber A., Zaha A., Thompson C., Bartholomeu D.C.,
RA   Luckemeyer D.D., Bahia D., Loreto E., Prestes E.B., Lima F.M.,
RA   Rodrigues-Luiz G., Vallejo G.A., Filho J.F., Monteiro K.M., Tyler K.M.,
RA   de Almeida L.G., Ortiz M.F., Siervo M.A., de Moraes M.H., Cunha O.L.,
RA   Mendonca-Neto R., Silva R., Teixeira S.M., Murta S.M., Sincero T.C.,
RA   Mendes T.A., Urmenyi T.P., Silva V.G., da Rocha W.D., Andersson B.,
RA   Romanha A.J., Steindel M., de Vasconcelos A.T., Grisard E.C.;
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESL06919.1}.
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DR   EMBL; AUPL01005399; ESL06919.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A061IW62; -.
DR   EnsemblProtists; ESL06919; ESL06919; TRSC58_05399.
DR   VEuPathDB; TriTrypDB:TRSC58_05399; -.
DR   OrthoDB; 5488599at2759; -.
DR   Proteomes; UP000031737; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR000241; RlmKL-like_Mtase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR   PANTHER; PTHR13370:SF3; TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG; 1.
DR   Pfam; PF01170; UPF0020; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:ESL06919.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031737};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ESL06919.1};
KW   tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..608
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012587837"
FT   DOMAIN          217..317
FT                   /note="UPF0020"
FT                   /evidence="ECO:0000259|Pfam:PF01170"
FT   REGION          381..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          531..608
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        381..395
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        555..572
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        579..602
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   608 AA;  66518 MW;  291DC837AEB0466E CRC64;
     MLFFAWFACD SSLAAFCVEE LRAAATTLGV EVSVLEPLPW LRAEAASRTF CVFETVSVAA
     AQQLAGRCVL LRAVHLLIAA AASLEDLLVC VGSSTAGGGD EDGRCLRGLL RSDETLRHMD
     CAVRVETIGR RYTLEEKSAL AARVSVALQL PCEASVPRAA EQPPYRVAVV IEHALENAPP
     GAPASWQPCG RVLCVFCGVP VAESPRQRLL ATYDLRRRPY IGTTSMPPEL AFVSVHMAKV
     RRGAYVLDPF CGTGSILVAA AHYGAVTLGA DADGRVMRSG SLRYRASRQQ QQQQDVVWRS
     HTQEALARAG ITAEEAAAPS MWTNFKLYGL KAPDRVRLNF ATWHAALRLC NLDCGERRSM
     IGHGAEDRGF LDAIVTDPPY GIREPRKKAE RPSGTTAAES DELATYPVSS ITLDLLLFAA
     EALVLGGRLV FWYPTTAQYT DDELPTHPSL HLVCDVPQQV SLKVVRRLVV LEKTQPLPFP
     LPSREACAAT RKPQDLRALM DVTDLPDNAN YMHYRSKLLR KRDATRRYLS TTPLPLCTPG
     GGHGSSGGGP GETKGRPRKL SRAERRDLVV ANRERNLQQQ WRRQQERLAG REGNDKCDGD
     GEGMSPSK
//