ID   A0A061J203_TRYRA        Unreviewed;       498 AA.
AC   A0A061J203;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Leucine-rich repeat protein (LRRP) {ECO:0008006|Google:ProtNLM};
GN   ORFNames=TRSC58_02834 {ECO:0000313|EMBL:ESL09443.1};
OS   Trypanosoma rangeli SC58.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX   NCBI_TaxID=429131 {ECO:0000313|EMBL:ESL09443.1, ECO:0000313|Proteomes:UP000031737};
RN   [1] {ECO:0000313|EMBL:ESL09443.1, ECO:0000313|Proteomes:UP000031737}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC58 {ECO:0000313|EMBL:ESL09443.1,
RC   ECO:0000313|Proteomes:UP000031737};
RA   Stoco P.H., Wagner G., Gerber A., Zaha A., Thompson C., Bartholomeu D.C.,
RA   Luckemeyer D.D., Bahia D., Loreto E., Prestes E.B., Lima F.M.,
RA   Rodrigues-Luiz G., Vallejo G.A., Filho J.F., Monteiro K.M., Tyler K.M.,
RA   de Almeida L.G., Ortiz M.F., Siervo M.A., de Moraes M.H., Cunha O.L.,
RA   Mendonca-Neto R., Silva R., Teixeira S.M., Murta S.M., Sincero T.C.,
RA   Mendes T.A., Urmenyi T.P., Silva V.G., da Rocha W.D., Andersson B.,
RA   Romanha A.J., Steindel M., de Vasconcelos A.T., Grisard E.C.;
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESL09443.1}.
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DR   EMBL; AUPL01002834; ESL09443.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A061J203; -.
DR   EnsemblProtists; ESL09443; ESL09443; TRSC58_02834.
DR   VEuPathDB; TriTrypDB:TRSC58_02834; -.
DR   OrthoDB; 123344at2759; -.
DR   Proteomes; UP000031737; Unassembled WGS sequence.
DR   GO; GO:0005929; C:cilium; IEA:UniProt.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR027038; RanGap.
DR   PANTHER; PTHR24113:SF12; F-BOX DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR24113; RAN GTPASE-ACTIVATING PROTEIN 1; 1.
DR   Pfam; PF13516; LRR_6; 5.
DR   SMART; SM00368; LRR_RI; 4.
DR   SUPFAM; SSF52047; RNI-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        33..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   498 AA;  54918 MW;  B9E891489B6970B7 CRC64;
     MDSNKFVAWG KISICVCFGC CFPMPLVDEF TTFLIVIARF FLFFFFRLPS TTGGFILYVC
     RGKWEGISVR MGKKEKIPPP GTSKDLTTNF YTRRKWRALL LQASLELQGK SIVPRGMLII
     GTALMKNRHI VHLDLSHNNI GDEGAVTMAE VLRKNETIQY LNLAQNGITD VGGIALASAF
     VPNVAPNGQP GQWNRTLFSI VLMGNDMGDG TLLAMSKAAA CHRDLVSVDL SWNNVGPLGT
     KCLLRSMQRN PLCMYHLMAN KIGDIGTAYL CEAMQRFAGK GIASLNLFRN DVRYKGCDAV
     GQLLENNEFL LDVSLHSNML GLKGMQVLRQ HFTAAPNRVR SLNLANCMLG DDGASEVAAL
     IAANPPSLER LNIANNGFSD DGGLIIVKAL LRNTFLIMVN CADNTFDTKT VDATGELIST
     TKTLKLLDFT KSIDSVDMRR TLAFAASDAE SIRIEVGEVQ EESFEDMLQH VAEHMQMILD
     AEAEKSKSKK SKKKPKKE
//