ID A0A061J2V5_TRYRA Unreviewed; 1156 AA.
AC A0A061J2V5;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 13-SEP-2023, entry version 34.
DE RecName: Full=isoleucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013165};
DE EC=6.1.1.5 {ECO:0000256|ARBA:ARBA00013165};
DE AltName: Full=Isoleucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00032665};
GN ORFNames=TRSC58_03654 {ECO:0000313|EMBL:ESL08640.1};
OS Trypanosoma rangeli SC58.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX NCBI_TaxID=429131 {ECO:0000313|EMBL:ESL08640.1, ECO:0000313|Proteomes:UP000031737};
RN [1] {ECO:0000313|EMBL:ESL08640.1, ECO:0000313|Proteomes:UP000031737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC58 {ECO:0000313|EMBL:ESL08640.1,
RC ECO:0000313|Proteomes:UP000031737};
RA Stoco P.H., Wagner G., Gerber A., Zaha A., Thompson C., Bartholomeu D.C.,
RA Luckemeyer D.D., Bahia D., Loreto E., Prestes E.B., Lima F.M.,
RA Rodrigues-Luiz G., Vallejo G.A., Filho J.F., Monteiro K.M., Tyler K.M.,
RA de Almeida L.G., Ortiz M.F., Siervo M.A., de Moraes M.H., Cunha O.L.,
RA Mendonca-Neto R., Silva R., Teixeira S.M., Murta S.M., Sincero T.C.,
RA Mendes T.A., Urmenyi T.P., Silva V.G., da Rocha W.D., Andersson B.,
RA Romanha A.J., Steindel M., de Vasconcelos A.T., Grisard E.C.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-
CC isoleucyl-tRNA(Ile); Xref=Rhea:RHEA:11060, Rhea:RHEA-COMP:9666,
CC Rhea:RHEA-COMP:9695, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58045, ChEBI:CHEBI:78442, ChEBI:CHEBI:78528,
CC ChEBI:CHEBI:456215; EC=6.1.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000114};
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESL08640.1}.
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DR EMBL; AUPL01003654; ESL08640.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A061J2V5; -.
DR EnsemblProtists; ESL08640; ESL08640; TRSC58_03654.
DR VEuPathDB; TriTrypDB:TRSC58_03654; -.
DR OrthoDB; 656at2759; -.
DR Proteomes; UP000031737; Unassembled WGS sequence.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07961; Anticodon_Ia_Ile_ABEc; 1.
DR CDD; cd00818; IleRS_core; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR HAMAP; MF_02003; Ile_tRNA_synth_type2; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033709; Anticodon_Ile_ABEc.
DR InterPro; IPR002301; Ile-tRNA-ligase.
DR InterPro; IPR023586; Ile-tRNA-ligase_type2.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR NCBIfam; TIGR00392; ileS; 1.
DR PANTHER; PTHR42780:SF1; ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR42780; SOLEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF19302; DUF5915; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR PRINTS; PR00984; TRNASYNTHILE.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000031737}.
FT DOMAIN 103..733
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 785..936
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
FT REGION 56..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1156 AA; 132445 MW; F27C77B2834D33B8 CRC64;
MLRRFTAVWR CAANGGSWKR KRSGLARCTV IRSRVHSTDP SSASLSSLGG SINHGELTKY
SSNSETAKGT NKGEMTDSKG VIGKGPLQNF DDELNFPKME EEVLQLWERV DAFRESFKQS
EGKKRYTFYD GPPFATGLPH YGHLLAGTIK DVVCRYAHQT GHCVERRFGW DCHGLPIEYE
IDKKLGIKTS HDVMALGIDK YNDTCQSIVM RYSEEWRKTV IRMGRWIDFD NDYKTMYMSY
MESVWWVFRQ LWDKGLIYRG FKVMPFSTAC STPLSNFEAN SNYQTVNDPS VMARFRTRDD
PNTYFIAWTT TPWTLPSNLA LCVHPDLDYV KVLESKTNRH YIVGEVRFSE VFPSKKKSGN
TNTEAPSYTI VSRMKGKDLI GTKYEPLFPY FKSVYGESAY RVIGDTYVET DSGTCVVHQA
PGFGEDDFRI CISNGIVNKE KVLCPVDENG RFHADVQDFA GRYVKDTDDD ILKYLDAKGL
LHSKGSVVHS YPFCWRSETP LIYKAVDSWF VNVESMHDSL LEANAKTEWV PNFVKTRRFS
NWLEGAKDWN LSRNRYWGTP LPVWHSEDWE EVVCVGSVKE LEELSGVTGI KNIHRQFVDV
ITIPSKRPGM PPLRRVEEVF DCWFESGSMP YAQSHYPFEK KEEFEQGRFP ADFVAEGLDQ
TRGWFYTLLV LGVALFNTSP FKNVVVNGLI LAEDGKKMSK RLKNYPEPSK IIDTHGADAL
RMYLINSPVV RAEPLCFCAQ GVRGIVKDVL LPLFHAAKFF IANANYCVLS GGSVSLDVVS
TNEMDRWILA STQTLQQYVK KEMDVYHLYN VVPGVLRFVV DLSNWYVRMN RRRMKNTLDQ
EDRSQALSTM LTVLFSVSRI ISPISPFVAE MLYQRIKPLL PVSQHMDSVH YLMFPEEDKG
KHDELLERAM KRMIVIVELA RVLRDRMVIS MKRPVRQAVI VHPDPVYLDD VRRVVQYIKD
EVNAFDVVLS SGEEYIITQL DANMEALGKR HRSEAPRLRK AIQQMSHDEV ENFLKNGRTE
VCGVPLTLDD VKVVRKIRDG IVDFESNTDN DVVVLLDKRE DQALVDSWRA REFVNRVQQL
RKKAKLVVTD VVDVYFESED LELTNSILNC AQQVNMTIQG KWDTMNKMPA AAKLVAEEDN
NISGVGIKIV FTEFLA
//