GenomeNet

Database: UniProt
Entry: A0A061J2V5_TRYRA
LinkDB: A0A061J2V5_TRYRA
Original site: A0A061J2V5_TRYRA 
ID   A0A061J2V5_TRYRA        Unreviewed;      1156 AA.
AC   A0A061J2V5;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   13-SEP-2023, entry version 34.
DE   RecName: Full=isoleucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013165};
DE            EC=6.1.1.5 {ECO:0000256|ARBA:ARBA00013165};
DE   AltName: Full=Isoleucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00032665};
GN   ORFNames=TRSC58_03654 {ECO:0000313|EMBL:ESL08640.1};
OS   Trypanosoma rangeli SC58.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX   NCBI_TaxID=429131 {ECO:0000313|EMBL:ESL08640.1, ECO:0000313|Proteomes:UP000031737};
RN   [1] {ECO:0000313|EMBL:ESL08640.1, ECO:0000313|Proteomes:UP000031737}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC58 {ECO:0000313|EMBL:ESL08640.1,
RC   ECO:0000313|Proteomes:UP000031737};
RA   Stoco P.H., Wagner G., Gerber A., Zaha A., Thompson C., Bartholomeu D.C.,
RA   Luckemeyer D.D., Bahia D., Loreto E., Prestes E.B., Lima F.M.,
RA   Rodrigues-Luiz G., Vallejo G.A., Filho J.F., Monteiro K.M., Tyler K.M.,
RA   de Almeida L.G., Ortiz M.F., Siervo M.A., de Moraes M.H., Cunha O.L.,
RA   Mendonca-Neto R., Silva R., Teixeira S.M., Murta S.M., Sincero T.C.,
RA   Mendes T.A., Urmenyi T.P., Silva V.G., da Rocha W.D., Andersson B.,
RA   Romanha A.J., Steindel M., de Vasconcelos A.T., Grisard E.C.;
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-
CC         isoleucyl-tRNA(Ile); Xref=Rhea:RHEA:11060, Rhea:RHEA-COMP:9666,
CC         Rhea:RHEA-COMP:9695, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58045, ChEBI:CHEBI:78442, ChEBI:CHEBI:78528,
CC         ChEBI:CHEBI:456215; EC=6.1.1.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00000114};
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESL08640.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AUPL01003654; ESL08640.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A061J2V5; -.
DR   EnsemblProtists; ESL08640; ESL08640; TRSC58_03654.
DR   VEuPathDB; TriTrypDB:TRSC58_03654; -.
DR   OrthoDB; 656at2759; -.
DR   Proteomes; UP000031737; Unassembled WGS sequence.
DR   GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR   GO; GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd07961; Anticodon_Ia_Ile_ABEc; 1.
DR   CDD; cd00818; IleRS_core; 1.
DR   Gene3D; 3.40.50.620; HUPs; 2.
DR   HAMAP; MF_02003; Ile_tRNA_synth_type2; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR002300; aa-tRNA-synth_Ia.
DR   InterPro; IPR033709; Anticodon_Ile_ABEc.
DR   InterPro; IPR002301; Ile-tRNA-ligase.
DR   InterPro; IPR023586; Ile-tRNA-ligase_type2.
DR   InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR   NCBIfam; TIGR00392; ileS; 1.
DR   PANTHER; PTHR42780:SF1; ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR   PANTHER; PTHR42780; SOLEUCYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF08264; Anticodon_1; 1.
DR   Pfam; PF19302; DUF5915; 1.
DR   Pfam; PF00133; tRNA-synt_1; 1.
DR   PRINTS; PR00984; TRNASYNTHILE.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363035};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363035};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363035};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031737}.
FT   DOMAIN          103..733
FT                   /note="Aminoacyl-tRNA synthetase class Ia"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
FT   DOMAIN          785..936
FT                   /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT                   anticodon-binding"
FT                   /evidence="ECO:0000259|Pfam:PF08264"
FT   REGION          56..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..73
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1156 AA;  132445 MW;  F27C77B2834D33B8 CRC64;
     MLRRFTAVWR CAANGGSWKR KRSGLARCTV IRSRVHSTDP SSASLSSLGG SINHGELTKY
     SSNSETAKGT NKGEMTDSKG VIGKGPLQNF DDELNFPKME EEVLQLWERV DAFRESFKQS
     EGKKRYTFYD GPPFATGLPH YGHLLAGTIK DVVCRYAHQT GHCVERRFGW DCHGLPIEYE
     IDKKLGIKTS HDVMALGIDK YNDTCQSIVM RYSEEWRKTV IRMGRWIDFD NDYKTMYMSY
     MESVWWVFRQ LWDKGLIYRG FKVMPFSTAC STPLSNFEAN SNYQTVNDPS VMARFRTRDD
     PNTYFIAWTT TPWTLPSNLA LCVHPDLDYV KVLESKTNRH YIVGEVRFSE VFPSKKKSGN
     TNTEAPSYTI VSRMKGKDLI GTKYEPLFPY FKSVYGESAY RVIGDTYVET DSGTCVVHQA
     PGFGEDDFRI CISNGIVNKE KVLCPVDENG RFHADVQDFA GRYVKDTDDD ILKYLDAKGL
     LHSKGSVVHS YPFCWRSETP LIYKAVDSWF VNVESMHDSL LEANAKTEWV PNFVKTRRFS
     NWLEGAKDWN LSRNRYWGTP LPVWHSEDWE EVVCVGSVKE LEELSGVTGI KNIHRQFVDV
     ITIPSKRPGM PPLRRVEEVF DCWFESGSMP YAQSHYPFEK KEEFEQGRFP ADFVAEGLDQ
     TRGWFYTLLV LGVALFNTSP FKNVVVNGLI LAEDGKKMSK RLKNYPEPSK IIDTHGADAL
     RMYLINSPVV RAEPLCFCAQ GVRGIVKDVL LPLFHAAKFF IANANYCVLS GGSVSLDVVS
     TNEMDRWILA STQTLQQYVK KEMDVYHLYN VVPGVLRFVV DLSNWYVRMN RRRMKNTLDQ
     EDRSQALSTM LTVLFSVSRI ISPISPFVAE MLYQRIKPLL PVSQHMDSVH YLMFPEEDKG
     KHDELLERAM KRMIVIVELA RVLRDRMVIS MKRPVRQAVI VHPDPVYLDD VRRVVQYIKD
     EVNAFDVVLS SGEEYIITQL DANMEALGKR HRSEAPRLRK AIQQMSHDEV ENFLKNGRTE
     VCGVPLTLDD VKVVRKIRDG IVDFESNTDN DVVVLLDKRE DQALVDSWRA REFVNRVQQL
     RKKAKLVVTD VVDVYFESED LELTNSILNC AQQVNMTIQG KWDTMNKMPA AAKLVAEEDN
     NISGVGIKIV FTEFLA
//
DBGET integrated database retrieval system