ID   A0A061J5D2_TRYRA        Unreviewed;      1142 AA.
AC   A0A061J5D2;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   22-FEB-2023, entry version 21.
DE   SubName: Full=Lipase domain protein {ECO:0000313|EMBL:ESL10618.1};
GN   ORFNames=TRSC58_01646 {ECO:0000313|EMBL:ESL10618.1};
OS   Trypanosoma rangeli SC58.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX   NCBI_TaxID=429131 {ECO:0000313|EMBL:ESL10618.1, ECO:0000313|Proteomes:UP000031737};
RN   [1] {ECO:0000313|EMBL:ESL10618.1, ECO:0000313|Proteomes:UP000031737}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC58 {ECO:0000313|EMBL:ESL10618.1,
RC   ECO:0000313|Proteomes:UP000031737};
RA   Stoco P.H., Wagner G., Gerber A., Zaha A., Thompson C., Bartholomeu D.C.,
RA   Luckemeyer D.D., Bahia D., Loreto E., Prestes E.B., Lima F.M.,
RA   Rodrigues-Luiz G., Vallejo G.A., Filho J.F., Monteiro K.M., Tyler K.M.,
RA   de Almeida L.G., Ortiz M.F., Siervo M.A., de Moraes M.H., Cunha O.L.,
RA   Mendonca-Neto R., Silva R., Teixeira S.M., Murta S.M., Sincero T.C.,
RA   Mendes T.A., Urmenyi T.P., Silva V.G., da Rocha W.D., Andersson B.,
RA   Romanha A.J., Steindel M., de Vasconcelos A.T., Grisard E.C.;
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESL10618.1}.
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DR   EMBL; AUPL01001646; ESL10618.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A061J5D2; -.
DR   EnsemblProtists; ESL10618; ESL10618; TRSC58_01646.
DR   VEuPathDB; TriTrypDB:TRSC58_01646; -.
DR   OrthoDB; 152257at2759; -.
DR   Proteomes; UP000031737; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   CDD; cd00519; Lipase_3; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002921; Fungal_lipase-like.
DR   PANTHER; PTHR45856; ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN; 1.
DR   PANTHER; PTHR45856:SF11; LIPASE_3 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01764; Lipase_3; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        215..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        252..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        411..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        449..469
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        490..513
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        525..551
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        572..587
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          893..1038
FT                   /note="Fungal lipase-like"
FT                   /evidence="ECO:0000259|Pfam:PF01764"
FT   REGION          653..687
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1142 AA;  128277 MW;  97C8DEAA7C2AD3FD CRC64;
     MTNICGATPE SLYQLDTWSS PCVQRRVMLS RDVDGSDFAV GGQLRAVSMD ALQDFMVGEE
     AMTESLEGDA IVNSTRLRRQ CNLRWVGSGQ GMSLNVKLNR FVRVILSMAS PQDQLPEGME
     WKRYPLMVAL EESPLSPDEE TSSSSRMQPP KGVFFYNTST VCYRTSPRCS SVVLPQTVAV
     VTKESQITLT IFDVDEALGN VSTASAVGIF FQRSAYTMST IVCRYVFLLF SILHLIRFIY
     RKRYSRTLYE QYWVMFLHLA LYLYLDPVFA VGIYATHSTA MYNFLEFRVP TYFAALLSCF
     IFALITASIN WTVTDRATAR SRSLSEREVG RQGMAPCFPV AISSPPLGTP RLTAAVSSVL
     TAPLQQQDEP KEEQHVPPGD ISRRASFVSS DGVRPMEVLH SATPLWATMS MTNYFLAVLF
     LDVAQSYVGS WDLGTEMACV SFACLYIRYT LYSLMLIFIV MCCVFLVQLH RSLGGCPYLE
     TRPQQLACRV FIFVFTTALI YFVVQVILIA FLYPQILGIV AYQPFTQLSS VIVSTFFVNY
     ITFVYTTTVA SRRVPIRPEN PQWRRVRWSR EWYRWLNLHG GILYIFHNER QERYFNWLQN
     SGKTFTKGRG GEGVLAGKRE RGDAEKQSAR ECGKANAFAV SFEREGATYC QTAAAGGEGG
     GRNFSPESSE SESENDDSCM GLLTESSRSP RIPQARSGVV DFLEKAERQL IDRPAIFIDH
     LEEALVDQLQ ALLFRRRGRM PFFNLETATD CLNLSWEAYL TTERVADTVG LAEESDTGLF
     QRLQRCYFCR GSAVGGETND NNNDDGGGTG EFNQCNRHNC STHDSNESGR ENYAGAEVPA
     VSVGEESLPV SGMNTEQYGY KKLAVFEVRE VRVVITVMDT TLPCHHRKLP RLVVAFRGTD
     NFSNAREDLR FRQRIWREID TTRHWGLKQR AKVHTGFLTM WLPLKEGVLR TIKSYLSEHR
     DKVCSMFCTG HSLGGALACL CAYSLQRMLR LMAYPLLEVT VYTYGQPPIG NKAFQTAYNK
     AVPRTFRVVN ESDVVSFLTL FGGCHVGIEV DIDRHGNYIC KPMFIERWFR PTQGRGFAVA
     NHTLASYAQS LNAVATRNGG GSCKLRCLEP YVGATELVSS ATAPQLAHSS SVARVEESPL
     VV
//