ID A0A061J9D4_TRYRA Unreviewed; 977 AA.
AC A0A061J9D4;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 22-FEB-2023, entry version 32.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=TRSC58_02373 {ECO:0000313|EMBL:ESL09902.1};
OS Trypanosoma rangeli SC58.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX NCBI_TaxID=429131 {ECO:0000313|EMBL:ESL09902.1, ECO:0000313|Proteomes:UP000031737};
RN [1] {ECO:0000313|EMBL:ESL09902.1, ECO:0000313|Proteomes:UP000031737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC58 {ECO:0000313|EMBL:ESL09902.1,
RC ECO:0000313|Proteomes:UP000031737};
RA Stoco P.H., Wagner G., Gerber A., Zaha A., Thompson C., Bartholomeu D.C.,
RA Luckemeyer D.D., Bahia D., Loreto E., Prestes E.B., Lima F.M.,
RA Rodrigues-Luiz G., Vallejo G.A., Filho J.F., Monteiro K.M., Tyler K.M.,
RA de Almeida L.G., Ortiz M.F., Siervo M.A., de Moraes M.H., Cunha O.L.,
RA Mendonca-Neto R., Silva R., Teixeira S.M., Murta S.M., Sincero T.C.,
RA Mendes T.A., Urmenyi T.P., Silva V.G., da Rocha W.D., Andersson B.,
RA Romanha A.J., Steindel M., de Vasconcelos A.T., Grisard E.C.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESL09902.1}.
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DR EMBL; AUPL01002373; ESL09902.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A061J9D4; -.
DR EnsemblProtists; ESL09902; ESL09902; TRSC58_02373.
DR VEuPathDB; TriTrypDB:TRSC58_02373; -.
DR OrthoDB; 1089019at2759; -.
DR Proteomes; UP000031737; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd01036; ClC_euk; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR11689:SF89; CHLORIDE CHANNEL PROTEIN; 1.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000031737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 124..146
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 172..196
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 287..310
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 322..340
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 378..399
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 495..514
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 526..549
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 570..595
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 601..621
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 849..906
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 60..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 977 AA; 106891 MW; CCC7077ACBB5BD0B CRC64;
MFRKFLDEFW DTANPFTRHS EDMTAEEAKK QSSFESFDYY KPYPSMYMTH LRAHYAGRTT
AASGGGRTGS TTATTTTNDN AGVPPMNDVV TVNIGGPLAP NTDGARLTVM NTVKKYDADE
RNEALRWILH VIIAIAVGVL ATTISYTVEF VDNYRAAQLY DLIKKHHMSG RFIGYLFSIG
VSMALVVVAA AVVVFFEPAA AGGGIPDVIA YLNGVHVPKA MKLRTFLAKS ISCMCAVAGG
LPVGLEAPLI HLGAIVGAGV TQGRSHALGC QTKLFQAFRN NKDRRDFITA GAACGVSAAF
GAPIGGLLFV MEEVSSFWDH SASGQIFLAT MICFTTIGII RSMLEDQQLL GWVSNAVSVL
FEVNLTIPLN LFSIVPSFFL GILCGAFAAV FTKVNLMLVK YRRRYLRPFV FRRFVEPLII
VLLYGTLSYM LALVPDCRPT HAMSSANGSF VWGTENRTQL FTATCATEDA YAPLATLTMG
TGKDTIRHLL SRQTIGEFPA VYILIFLTLY TFFASWSSGT AVSGGLVVPS LVIGAAFGRL
YGQILWFLAV RGAGAERSYK VSQAWLDPGV FALIGAGAFF SGTSRMTMSI CVIMVELSSE
LHYLLPVMVA IIMSKTVADF ISEPLYHHML RLDSVPYLQA HLLRPGFEQL TAADVMTSKV
VTLRLREKTS VVLNALRHTT HHAFPVVEAV QEERSERGNC PVNGKPLGRE ELGEEEEEKR
VRYKFVGLVT REDVHIFLAL PALYSAHQSS GSSDLRGRGS GLELAPSVLA INKMTWAEWL
THKTSLFFVL GSKRWLEIWA RGNNTAGVLE KVDVDASESN DPNGSEDRPN PLSVDERRLP
PVLDFSLIVN RSPWVIPPFF NLQMAYHTFR MMGLRHMVVV DGDAVVGIIT RKDLLVDTLL
RRLRELHGEN NNGGSAGNTP PASLSVPDEH DGISFSSRSR TEGFMQTVAS SSLPSSQVDI
PNLLFLGSAN TDAGPHK
//
