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Database: UniProt
Entry: A0A061LU84_9MICO
LinkDB: A0A061LU84_9MICO
Original site: A0A061LU84_9MICO 
ID   A0A061LU84_9MICO        Unreviewed;       711 AA.
AC   A0A061LU84;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   08-MAY-2019, entry version 30.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:EYT52509.1};
GN   ORFNames=H490_0112750 {ECO:0000313|EMBL:EYT52509.1};
OS   Leucobacter sp. UCD-THU.
OC   Bacteria; Actinobacteria; Micrococcales; Microbacteriaceae;
OC   Leucobacter.
OX   NCBI_TaxID=1292023 {ECO:0000313|EMBL:EYT52509.1, ECO:0000313|Proteomes:UP000026917};
RN   [1] {ECO:0000313|EMBL:EYT52509.1, ECO:0000313|Proteomes:UP000026917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCD-THU {ECO:0000313|EMBL:EYT52509.1,
RC   ECO:0000313|Proteomes:UP000026917};
RX   PubMed=23792744; DOI=10.1128/genomeA.00325-13;
RA   Holland-Moritz H.E., Bevans D.R., Lang J.M., Darling A.E., Eisen J.A.,
RA   Coil D.A.;
RT   "Draft Genome Sequence of Leucobacter sp. Strain UCD-THU (Phylum
RT   Actinobacteria).";
RL   Genome Announc. 1:S69-S82(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EYT52509.1}.
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DR   EMBL; APJM01000024; EYT52509.1; -; Genomic_DNA.
DR   RefSeq; WP_017882524.1; NZ_APJM01000024.1.
DR   EnsemblBacteria; EYT52509; EYT52509; H490_0112750.
DR   OrthoDB; 977512at2; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000026917; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000026917};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296};
KW   Reference proteome {ECO:0000313|Proteomes:UP000026917}.
FT   DOMAIN      344    523       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      526    615       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   711 AA;  76378 MW;  2D084A9DEF5763A2 CRC64;
     MTDYSKIDFS PIIDASADEV VTESYVRDVA LPSGGALALI TLDNGRDHTR PNTLGPRTLQ
     GLERVLDEQR DRAAAGEIRA VAVTGKPFIF AAGADLSKVS TLATEQNARL MAQYGHRVLG
     KLGKLGVPSF AFVNGLALGG AMEIALGCDY RTLDSSAAAL AFPEVFLGII PGWGGATLVP
     NLIGIENALE IIVSNPLKNN RMLKPKQAYE MGLFDAMFGA ASFLERSVAW ADGVIEGRVK
     VDRPHAPGKL ERLTKWPAAI KIARDTLKAR IGTAAKAPYV ALDLLSAAKD NDIERGFERE
     DDALAQLISS DQFAASIYAF DLVQKRAKRP AGAPDRELAR PVKKVGVIGA GLMASQFALL
     FARKLRVPVL ITDLDQARVD KGLEYIRGEI DKMHQKGRLS SDDANQVKAL VSGTTDKALY
     ADCDWVIEAV FEELGVKQQV FAEIEPIISP EAIIATNTSS LSVEQIGAKL AHPERLVGFH
     FFNPVAVMPL IEVVKVPATD DAALATAMSV AKKLGKSAVI TADRPGFVVN RLLAKVMGEA
     ARALDEGTPM PVVERALAPI GLPMGPFELI DLVGWKVAAH VQDTMVHAFP DRFYASENLH
     RLAEVDEPLV KTKHGKVEDL SKAGKKAVTL GKTAASEEEI LRRVEDELAN EIKIMLDEGV
     VAAAEDIDLC LILGAGWPFQ AGGATPYLDR VGASERAFGG VFHEPRIQGA R
//
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