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Database: UniProt
Entry: A0A062U5X3_9RHOB
LinkDB: A0A062U5X3_9RHOB
Original site: A0A062U5X3_9RHOB 
ID   A0A062U5X3_9RHOB        Unreviewed;       414 AA.
AC   A0A062U5X3;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   10-APR-2019, entry version 27.
DE   RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|HAMAP-Rule:MF_00138};
DE            EC=6.3.4.13 {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=GARS {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
GN   Name=purD {ECO:0000256|HAMAP-Rule:MF_00138};
GN   ORFNames=HY2_11165 {ECO:0000313|EMBL:KCZ51560.1};
OS   Hyphomonas sp. T16B2.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Hyphomonadaceae; Hyphomonas.
OX   NCBI_TaxID=1280941 {ECO:0000313|EMBL:KCZ51560.1, ECO:0000313|Proteomes:UP000027006};
RN   [1] {ECO:0000313|Proteomes:UP000027006}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T16B2 {ECO:0000313|Proteomes:UP000027006};
RA   Lai Q., Shao Z.;
RT   "Hyphomonas sp. T16B2 Genome Sequencing.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KCZ51560.1, ECO:0000313|Proteomes:UP000027006}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T16B2 {ECO:0000313|EMBL:KCZ51560.1,
RC   ECO:0000313|Proteomes:UP000027006};
RX   PubMed=27255138; DOI=10.1007/s10482-016-0712-7;
RA   Li X., Li C., Lai Q., Li G., Sun F., Shao Z.;
RT   "Hyphomonas pacifica sp. nov., isolated from deep sea of the Pacific
RT   Ocean.";
RL   Antonie Van Leeuwenhoek 109:1111-1119(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58089,
CC         ChEBI:CHEBI:58457, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00138};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- SIMILARITY: Belongs to the GARS family. {ECO:0000256|HAMAP-
CC       Rule:MF_00138}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KCZ51560.1}.
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DR   EMBL; AWFA01000013; KCZ51560.1; -; Genomic_DNA.
DR   STRING; 1280941.HY2_11165; -.
DR   EnsemblBacteria; KCZ51560; KCZ51560; HY2_11165.
DR   PATRIC; fig|1280941.3.peg.1245; -.
DR   UniPathway; UPA00074; UER00125.
DR   Proteomes; UP000027006; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Complete proteome {ECO:0000313|Proteomes:UP000027006};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00138, ECO:0000313|EMBL:KCZ51560.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00138};
KW   Reference proteome {ECO:0000313|Proteomes:UP000027006}.
FT   DOMAIN       89    294       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
SQ   SEQUENCE   414 AA;  43271 MW;  B271165B7A31781E CRC64;
     MAQSALVDMV HSTPGNPGMD DVGPCFDVAV TDIDKLVQLT LQVEPDLVVI GPEAPLAAGL
     ADVLRARGFD VFGPSAQAAQ LESSKAFSKA RMKEYGVPTA AYGEFTDPVL AKSYLRTLDA
     PYVLKADGLA AGKGVVIAPT LEEADAEIDE MLSGKFGDAS ATLVIEEFMH GEEASIFVIT
     DGTGAVYLPA AQDHKRAGDG DTGPNTGGMG AYAPAPVVTD EILARVKKEI VQPMLKGMKR
     DGMPYQGVLY VGIMVTADGP KVVEFNARFG DPECQVLMKG LSGDIVPAIL GAATGGLEGN
     EEAFEALLEL DRFEPTATIV LATEGYPGSY AKGSVIRGVK TANDLPGVTV FHAGTDMDEG
     GVLVANGGRV LNVTASGETL KEAVERAYAG VNAIDWPEGF CRRDIGWRAL GETT
//
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