ID A0A062V235_9EURY Unreviewed; 484 AA.
AC A0A062V235;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Formate hydrogenlyase subunit 3/multisubunit Na+/H+ antiporter, MnhD subunit {ECO:0000313|EMBL:KCZ70698.1};
GN ORFNames=ANME2D_02721 {ECO:0000313|EMBL:KCZ70698.1};
OS Candidatus Methanoperedens nitroreducens.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Candidatus Methanoperedenaceae; Methanoperedens.
OX NCBI_TaxID=1392998 {ECO:0000313|EMBL:KCZ70698.1, ECO:0000313|Proteomes:UP000027153};
RN [1] {ECO:0000313|EMBL:KCZ70698.1, ECO:0000313|Proteomes:UP000027153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ANME-2d {ECO:0000313|EMBL:KCZ70698.1,
RC ECO:0000313|Proteomes:UP000027153};
RX PubMed=23892779; DOI=10.1038/nature12375;
RA Haroon M.F., Hu S., Shi Y., Imelfort M., Keller J., Hugenholtz P., Yuan Z.,
RA Tyson G.W.;
RT "Anaerobic oxidation of methane coupled to nitrate reduction in a novel
RT archaeal lineage.";
RL Nature 500:567-570(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KCZ70698.1}.
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DR EMBL; JMIY01000007; KCZ70698.1; -; Genomic_DNA.
DR RefSeq; WP_048092512.1; NZ_JMIY01000007.1.
DR AlphaFoldDB; A0A062V235; -.
DR PATRIC; fig|1392998.3.peg.3019; -.
DR OrthoDB; 19089at2157; -.
DR Proteomes; UP000027153; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR42682; HYDROGENASE-4 COMPONENT F; 1.
DR PANTHER; PTHR42682:SF5; HYDROGENASE-4 COMPONENT F; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
PE 4: Predicted;
KW Lyase {ECO:0000313|EMBL:KCZ70698.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000027153};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..91
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 125..415
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
SQ SEQUENCE 484 AA; 53410 MW; 54C5CF14D181FDEC CRC64;
MIEYLLLAPV ITGILCLFTK TRKQVEVVSL TGSIITLLLG LILVVQVYRY DIIISWQNAL
FADAFSAFIV LIVSIVGFVA SIYSTGYMGH ELEHRIIDLR KLRIYYALFH VFMFTMLLVG
VTNNLGLWIA IEMTTLVSAL LMILYSRKSS IEAAWKYMII CTVGITFALF GTILTYYASV
NILGETGEAL NWTSLLAVAD QFDPAIMRLA FIFILIGYGT KAGLAPMHTW LPDAHSEAPT
PVSALLSGVL LNCAMYGIIR FNTIASRSTG TEFSSNLLIV FGLLSIGIAV PFILLQEDYK
RLLAYSSVEH MGIVALGIGF GGIFGVFGAI LHMFNHAMTK SFMFFGAGNV LLKHKTKEID
KVSGTLKSMP FTGPMLIIGG LAITGSPPFS IFISEFTILA AGFSRGYIVS SVLFLLFIII
IFAGFFYHIS RMVLGVPKPE IKTGEVSRWM LGAMAVLIVF MFVLGVYIPP YFYEMLMKVV
NVVR
//
