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Database: UniProt
Entry: A0A066TJ12_9NEIS
LinkDB: A0A066TJ12_9NEIS
Original site: A0A066TJ12_9NEIS 
ID   A0A066TJ12_9NEIS        Unreviewed;       422 AA.
AC   A0A066TJ12;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   11-DEC-2019, entry version 33.
DE   RecName: Full=Cytosine-specific methyltransferase {ECO:0000256|RuleBase:RU000417};
DE            EC=2.1.1.37 {ECO:0000256|RuleBase:RU000417};
GN   ORFNames=SALWKB12_0367 {ECO:0000313|EMBL:KDN13512.1};
OS   Snodgrassella alvi.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Snodgrassella.
OX   NCBI_TaxID=1196083 {ECO:0000313|EMBL:KDN13512.1, ECO:0000313|Proteomes:UP000027090};
RN   [1] {ECO:0000313|EMBL:KDN13512.1, ECO:0000313|Proteomes:UP000027090}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=wkB12 {ECO:0000313|Proteomes:UP000027090};
RA   Kwong W.K., Engel P., Koch H., Moran N.A.;
RT   "The genomes of two eusocial bee gut symbionts.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC         methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC         Evidence={ECO:0000256|RuleBase:RU000417};
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC       ProRule:PRU01016, ECO:0000256|RuleBase:RU000416}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KDN13512.1}.
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DR   EMBL; JFZW01000001; KDN13512.1; -; Genomic_DNA.
DR   RefSeq; WP_037405084.1; NZ_JFZW01000001.1.
DR   STRING; 1196083.SALWKB12_0367; -.
DR   EnsemblBacteria; KDN13512; KDN13512; SALWKB12_0367.
DR   PATRIC; fig|1196083.5.peg.165; -.
DR   Proteomes; UP000027090; Unassembled WGS sequence.
DR   GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR018117; C5_DNA_meth_AS.
DR   InterPro; IPR001525; C5_MeTfrase.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   Pfam; PF00145; DNA_methylase; 1.
DR   PRINTS; PR00105; C5METTRFRASE.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00675; dcm; 1.
DR   PROSITE; PS00094; C5_MTASE_1; 1.
DR   PROSITE; PS51679; SAM_MT_C5; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01016,
KW   ECO:0000256|RuleBase:RU000417, ECO:0000313|EMBL:KDN13512.1};
KW   S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01016};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU01016,
KW   ECO:0000256|RuleBase:RU000417, ECO:0000313|EMBL:KDN13512.1}.
FT   ACT_SITE        70
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ   SEQUENCE   422 AA;  48195 MW;  5175EC41BCBB0A2F CRC64;
     MKFIDLFAGL GGFHVGLANN GHECVFACEI ETELRNLYKS NYGIQPFDDV TKIDVTKIPS
     HEIICAGFPC QPFSLAGQKK GAECPKSGKL IEHVIRIAEF HNPQFILLEN VPNIVTIANG
     TFWSYLTNSF KNIGYKIYHK IISPVDIGIP QNRKRIFIVA VRQDIDNGNF NWPDTTQLKN
     IDLSEILDKS NIHKHLESKK TMLLKHWQKL LNQLSISELR STSLVAPEFG ATYPHDFQQI
     SFEEMKKYKG AYGQDLSNCN SWDEIMEKLP SYTNKYFKIP DWLVKSALKS RELFSQNANI
     CTKWVAELDK KNNSWQILEW RGNFNDLNIY NHLVQFRASG IRILRPNVAP SLISMTPTQI
     PIIPAEDRYL SPYEAAKLQN LHKLHQLPQG TVKAFKALGN AVNAKIVEFI TKNLNIDYGI
     LN
//
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