ID A0A066VEL0_TILAU Unreviewed; 1340 AA.
AC A0A066VEL0;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Ras GEF {ECO:0000313|EMBL:KDN39851.1};
GN ORFNames=K437DRAFT_264458 {ECO:0000313|EMBL:KDN39851.1};
OS Tilletiaria anomala (strain ATCC 24038 / CBS 436.72 / UBC 951).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Exobasidiomycetes; Georgefischeriales; Tilletiariaceae; Tilletiaria.
OX NCBI_TaxID=1037660 {ECO:0000313|EMBL:KDN39851.1, ECO:0000313|Proteomes:UP000027361};
RN [1] {ECO:0000313|EMBL:KDN39851.1, ECO:0000313|Proteomes:UP000027361}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UBC 951 {ECO:0000313|EMBL:KDN39851.1,
RC ECO:0000313|Proteomes:UP000027361};
RG DOE Joint Genome Institute;
RA Toome M., Kuo A., Henrissat B., Lipzen A., Tritt A., Yoshinaga Y., Zane M.,
RA Barry K., Grigoriev I.V., Spatafora J.W., Aimea M.C.;
RT "Draft genome sequence of a rare smut relative, Tilletiaria anomala UBC
RT 951.";
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KDN39851.1}.
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DR EMBL; JMSN01000099; KDN39851.1; -; Genomic_DNA.
DR RefSeq; XP_013241184.1; XM_013385730.1.
DR STRING; 1037660.A0A066VEL0; -.
DR GeneID; 25265712; -.
DR HOGENOM; CLU_255052_0_0_1; -.
DR InParanoid; A0A066VEL0; -.
DR OMA; WVCSEIL; -.
DR OrthoDB; 5476208at2759; -.
DR Proteomes; UP000027361; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF364; GUANINE NUCLEOTIDE EXCHANGE FACTOR LTE1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000027361}.
FT DOMAIN 351..481
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1019..1340
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 158..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 949..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..614
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 684..710
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 964..984
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1340 AA; 146413 MW; 2D99C04AC75DF3EC CRC64;
MKPLEAVTGG SLASAKDEAT DVPEDFAPLE TTNFNAVKAL IAKYELEIDP SVTREQAEAI
GDLGSGTPFV IRAQKLEGGR AVWKVTKRVT DTDLATMHHD GMSTSSLSSG SQFEDNDGNP
LQSGDVLGAV LGTHPCFPSL KPPVLVGKTG STSRLRLSAP VRDDQQAING PPFGPSVQFH
PFSRGDWKRT RRLSCASASA PSLSDADAAD SSGLEGPNAF DLLQSHDAIV DEAASLEDTG
ARSSKDSQSS SSYSRKRRRR ASFSNDPRYA IWGAPCHPNR RAVVQTSGPG APVPLESIDP
ASSGNGPVKS ISCFSASMQH HPIVKGSLTK EEADAIPPLR DYQMAAIFPK DHAALLAASL
ERVIVQLTSV IDTRLHIDFF YTYRSFTTSH TLLDLLIERF NWSLELIVSF RDAHVQSVVR
VRTYVVLKFW LIHFFEEDFL PDRQLRNRLT TWLNSFGDLS SRNVAEAGVI SSLRKTVVKL
KHLYSQSGVS GLLGQGDDQF RQGGISQPTM AASSSSGSLS ESEVDLERLS DPLTVARERK
GTREVFSTFN GAPAKALDAM SHGRNSSTQG AGFGSISRAL NSTVHKIQKM RMIAQRRETA
MSSAATTSSD AVPNDTGDLL FIKGGLESFI DFFQLPAGEK DAGDYSASSS STAGDAHTPS
LDSVSEAAES TPATSVDLPR QSNEATVEET HGHTQDWESG PSDVCKDMRS SESSEAVPNM
ACTKVGADNL HHTTSEQTLR SPTRRLRLAA SSSSTSLRKQ QGPSLVGHST SPFPGIVQID
DVDLSSDEDD DAVRKALRRL PGARDLRTAR RAFGSVQSKL LASDSVGDAP WSSPPEQLAA
EGDPPFNSQG QQKFGYLTTE LFDPDEALAG YELIKGFNLD GFESDEDEPG DAEAALRKLE
GYIDEGKVKA RARKVEALWQ NSRASKAKHH SSEPGAVTEA AVEDVPAAIV PPSSGKDSFV
PPHESNERSS SLPMRSSEDA QAQKGNQLEE PGLDKRFATS QFGSWSLPPV HRSFLLDCRS
EDIAGQMSLI EAELFSHITW QELASGRWQS FRQRCEISDW EEYYRIRMRE KAEAEEAQAT
WDEDNIGVIV ARFNLAANWV ASEVVLTQNL IERAAVISKF IRVAWKCYQV ANFASMTQIV
FGLQSPWVER LHRTWTRIPP WEMRILRDLR TLTSPTRNFR HMRRVVDVMI SEEGMEEIVN
SAGPPDVFSM STSGQFPSHS TAFKGCVPFC GLLLMDLMEN QILPTCLPAH ALDPAADYGA
TPAQHLEEDL PPLPPQLPVK PLVNVLKFRV LGMIIKTVIA FQERSKSYDF TASGPLYLRC
LKLRCLSAPL MTQLSRMAEP
//
