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Database: UniProt
Entry: A0A066X3A0_COLSU
LinkDB: A0A066X3A0_COLSU
Original site: A0A066X3A0_COLSU 
ID   A0A066X3A0_COLSU        Unreviewed;       528 AA.
AC   A0A066X3A0;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   11-DEC-2019, entry version 23.
DE   RecName: Full=Ribosomal RNA-processing protein 8 {ECO:0000256|RuleBase:RU365074};
DE            EC=2.1.1.- {ECO:0000256|RuleBase:RU365074};
GN   ORFNames=CSUB01_08745 {ECO:0000313|EMBL:KDN60181.1};
OS   Colletotrichum sublineola (Sorghum anthracnose fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum.
OX   NCBI_TaxID=1173701 {ECO:0000313|EMBL:KDN60181.1, ECO:0000313|Proteomes:UP000027238};
RN   [1] {ECO:0000313|Proteomes:UP000027238}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TX430BB {ECO:0000313|Proteomes:UP000027238};
RX   PubMed=24926053; DOI=10.1128/genomeA.00540-14;
RA   Baroncelli R., Sanz-Martin J.M., Rech G.E., Sukno S.A., Thon M.R.;
RT   "Draft genome sequence of Colletotrichum sublineola, a destructive pathogen
RT   of cultivated sorghum.";
RL   Genome Announc. 2:E0054014-E0054014(2014).
CC   -!- FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that
CC       specifically methylates the N(1) position of adenine in helix 25.1 in
CC       25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis.
CC       Required for efficient pre-rRNA cleavage at site A2.
CC       {ECO:0000256|RuleBase:RU365074}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|RuleBase:RU365074}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. RRP8 family.
CC       {ECO:0000256|RuleBase:RU365074}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KDN60181.1}.
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DR   EMBL; JMSE01001544; KDN60181.1; -; Genomic_DNA.
DR   STRING; 1173701.A0A066X3A0; -.
DR   EnsemblFungi; KDN60181; KDN60181; CSUB01_08745.
DR   OMA; MFDEYHE; -.
DR   OrthoDB; 850836at2759; -.
DR   Proteomes; UP000027238; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.2150; -; 1.
DR   InterPro; IPR007823; RRP8.
DR   InterPro; IPR042036; RRP8_N.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   PANTHER; PTHR12787; PTHR12787; 1.
DR   Pfam; PF05148; Methyltransf_8; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|RuleBase:RU365074,
KW   ECO:0000313|EMBL:KDN60181.1}; Nucleus {ECO:0000256|RuleBase:RU365074};
KW   Reference proteome {ECO:0000313|Proteomes:UP000027238};
KW   rRNA processing {ECO:0000256|RuleBase:RU365074};
KW   S-adenosyl-L-methionine {ECO:0000256|RuleBase:RU365074};
KW   Transferase {ECO:0000256|RuleBase:RU365074, ECO:0000313|EMBL:KDN60181.1}.
FT   REGION          1..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          258..279
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..80
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..133
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..163
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   528 AA;  57891 MW;  90C10F533E02CC12 CRC64;
     MFAVPGWSVS ADALKPETQV DKKHSTSKNN SAKKRKKAKK EERSHGTGAN KVLVNPRVFG
     GAKDDEPMKG SGKRAAPADD EVEDNDDGEA ATPKPSKKQK KDSKSERDAQ ETPKSDKKDK
     KQRKEKPSKH GEASSETPSK AAQKPTPRKE EASTEDKKKA TKEAAAAIAA SVPPIPPPAA
     KLTPLQRSMR QKLISARFRH LNETLYTRPS AQAYQLFEDS PEMFSEYHEG FRRQVEVWPE
     NPVDGYIRDL KLRAKARYSD ARGRPGAQPT PSGPAPLPRT NGVCHVADLG CGDARLASTL
     EPEAKKLKLK VLSYDLHSPA EHVIKADIAN LPLADDAVDV AIFCLALMGT NWLDFIEEAY
     RILHWKGELW VAEIKSRFGP VRQKNAVVSH SVGNRKKAAA AATAKKVKAD EPEETEADRV
     ALAVEVDGHE DKRGETDVSA FVEALKKRGF VLAGEGEGNK GAVDLSNKMF VKMRFIKGAV
     PTKGKGVAAA KAAGFVDKGK KQKRFVWETE EDKVDETAIL KPCLYKIR
//
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