ID A0A066X3W2_COLSU Unreviewed; 1513 AA.
AC A0A066X3W2;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000256|ARBA:ARBA00015369};
DE AltName: Full=Carboxypeptidase Y receptor {ECO:0000256|ARBA:ARBA00031354};
DE AltName: Full=Sortilin VPS10 {ECO:0000256|ARBA:ARBA00031250, ECO:0000256|ARBA:ARBA00031902};
DE AltName: Full=Vacuolar carboxypeptidase Sorting receptor VPS10 {ECO:0000256|ARBA:ARBA00032705, ECO:0000256|ARBA:ARBA00032910};
GN ORFNames=CSUB01_02409 {ECO:0000313|EMBL:KDN62379.1};
OS Colletotrichum sublineola (Sorghum anthracnose fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum graminicola species complex.
OX NCBI_TaxID=1173701 {ECO:0000313|EMBL:KDN62379.1, ECO:0000313|Proteomes:UP000027238};
RN [1] {ECO:0000313|Proteomes:UP000027238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TX430BB {ECO:0000313|Proteomes:UP000027238};
RX PubMed=24926053; DOI=10.1128/genomeA.00540-14;
RA Baroncelli R., Sanz-Martin J.M., Rech G.E., Sukno S.A., Thon M.R.;
RT "Draft genome sequence of Colletotrichum sublineola, a destructive pathogen
RT of cultivated sorghum.";
RL Genome Announc. 2:E0054014-E0054014(2014).
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment. {ECO:0000256|ARBA:ARBA00025569}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004488}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004488}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KDN62379.1}.
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DR EMBL; JMSE01001327; KDN62379.1; -; Genomic_DNA.
DR STRING; 1173701.A0A066X3W2; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_0_1; -.
DR OMA; ATMSEFI; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000027238; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
PE 4: Predicted;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000027238};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022927}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1513
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001629746"
FT TRANSMEM 1383..1404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1433..1454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..687
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 737..1372
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
SQ SEQUENCE 1513 AA; 169779 MW; 7A81642EC4661A40 CRC64;
MRLRGKAAAS WRILLSVLTL AAAVQAKDEP TIKVTSIKHP PLNLNYFEDS NIILYQDVSE
RNLYRSEDAG VTWDRVKDIP ENQASLLTMH GFDKSRAYVM TEGTEHYKTT DRGKSWQKFE
SGAPPNIFVG GDILHFHAGD PDRVIFNGAD CIGIFCDLIT LYTTDNFKSK AKFLRGNTEG
CYWAKSSDLF TTGKEDLDKQ RILCIVRGNF SPFKEDNRLL ASDNFFEKVD NKIQEFEPDM
DTNHGVQGVV NLAVVKKYLM VATTSLNTDE MALFVTDDTI KWHRAMFPTN HGHKVNQEAY
TVLESTNYSI QIDVMNTRPS NPTGVMFTSN SNGTFFTENL EHTNRNTMGH VDFEKITGVQ
GIFMVNTVKN WEEVEKGGSR HVQKEIVSKI TFDDGRTFHD LKSGGDQLHI HSVTDLDNVG
RVFSSPAPGL VLAIGNKGKS LGKFGDGDVY VSDDAGVTWK KALDGHHKYE FGDQGSILVA
VKDSNKEDIG EIRYSLDHGD SWKTASLPDD LKIKPELLTT TQDSTSLKFL LVGKTGGDNA
KFHIIALDFE GLHERTCKDD DLEDWHARLD DNGKPSCLMG HKQTYRRRKK TADCFLNQEF
KDPVPVTEDC ECTDADFECD YNFVKDGDNC KKAGPIIAPD NACKNAKPDD TFKGSSGWRK
IPGNTCKRKS GDQKDDLVER KCSEAVNAPA APVDGKIKAT QHVFKTDFKD FEKIYLERGE
SSTEVDETII VRPVEYSGNS MRADKQIWRT KDHGKNWERI LEDEAVRGIY PHSFFKDVVF
FTTDSNKVLY TIDRAEHFHS FEAPTKPGSS NPLSFHPDKK DWLIWVGEKC EKVNGKETCF
NEASISRDRG DNWKTAMRYV QKCEFTGHSA YKYRDLRQIV CLARKEENDE KDNPKVIVSS
NDFFDEDKKT HQDNVKNFAT MAEFIVVAAE DQEKQGLRAL ASLDGITYAE AHFPVNFKVS
HQNAYTVLDS STHAVNLFVA TETAEGRRHG SIIKSNSNGT SYVMSAQAVN CNDEYYVDFE
KIPGLEGVAL INTVANRDKR NEPKKVQTQI SHNDGSQWAF LPPPKADVDG KPYSCSSTKG
DEKCALHLHH YTERADKKKT FSVDTAVGLM FGNGNVGPSL SSLKEADTFM TTDAGITWKN
VKKGAWTWQY GDQGSIVVLV QRASRENQVK TKTISYTTDE GKTWKDFTFT DKEVTVLDIS
TLRSGTSRNF LIWCKDDGGE MFSVNVDFTG LADRPCKSGE GSSDYYLWSP KHPSQPDNCL
FGHVSQYLRK KDDANCYNDA RIQPLYQLDN CTCTRADYEC DYNFELDAHQ QCKLVPGKSP
ISAEQWCKEN PDAVEYYEPT GFRRIPLTTC TGNGYNELDK QTKAHPCAGK EDEFERQRRT
SGIAIFFAVV IPFGLAGAIG WWVYRNWNGK IGQIRLGESS SFDNDAPWVK YPVIALSAVV
AVAAALPLVA SALWRRATSV YESVSGGGGV SWLNGRGNRR FTTRDSFARG RGDYAVVDDD
EGELLGDDSD EEV
//
