ID A0A066XTW3_COLSU Unreviewed; 676 AA.
AC A0A066XTW3;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 13-SEP-2023, entry version 45.
DE SubName: Full=Putative methylenetetrahydrofolate reductase {ECO:0000313|EMBL:KDN69166.1};
GN ORFNames=CSUB01_06669 {ECO:0000313|EMBL:KDN69166.1};
OS Colletotrichum sublineola (Sorghum anthracnose fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum graminicola species complex.
OX NCBI_TaxID=1173701 {ECO:0000313|EMBL:KDN69166.1, ECO:0000313|Proteomes:UP000027238};
RN [1] {ECO:0000313|Proteomes:UP000027238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TX430BB {ECO:0000313|Proteomes:UP000027238};
RX PubMed=24926053; DOI=10.1128/genomeA.00540-14;
RA Baroncelli R., Sanz-Martin J.M., Rech G.E., Sukno S.A., Thon M.R.;
RT "Draft genome sequence of Colletotrichum sublineola, a destructive pathogen
RT of cultivated sorghum.";
RL Genome Announc. 2:E0054014-E0054014(2014).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KDN69166.1}.
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DR EMBL; JMSE01000545; KDN69166.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A066XTW3; -.
DR STRING; 1173701.A0A066XTW3; -.
DR eggNOG; KOG0564; Eukaryota.
DR HOGENOM; CLU_025841_2_1_1; -.
DR OMA; GVFKTIP; -.
DR OrthoDB; 1381745at2759; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000027238; Unassembled WGS sequence.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR004621; Fadh2_euk.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR NCBIfam; TIGR00677; fadh2_euk; 1.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF1; METHYLENETETRAHYDROFOLATE REDUCTASE 1; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000027238}.
SQ SEQUENCE 676 AA; 75120 MW; 7026376DCEE0F211 CRC64;
MEKIKDKIGA LPANANYFSL EFFPPKTAMG LSNLRDRLDR MERALRPLFV NVTWGAGGST
STKSLELAEI CQRELGLTTC LHLTCTNMSR KLIDKALEDA KALGIRNILA LRGDPPRKSE
YRNAEDFDVD DVEDFVWAVD LVRYIRKNYG DYFCVGVAAY PEGHADESHP QGQSFEHDLP
YLVEKVQAGA DFIMTQLFFD IKAYDKFEKT LKEHPSGAFK DIIIIPGLMP IQSYQMIKRT
TKLSHAKIPD NLMARLDAVK GDDEKVKQVG VDILSELVEQ VKEVKSRTPG PKGFHFYTLN
LEKAVSFILE RTGLIPDHRS EDEEAVIDDG PGVPVSIPAV QLNGLAPIHP AARALSGRRH
SSMGSSDPHN RIIVSSASNP AYETTAVDLS NSEPVNTRAN TLAISEGVGA VGREATWDDF
PNGRWGDARS PAYGEIDGYG VSLHMSVTQA IRLWGTPKTV QDINNIFIRH IKGQLGAIPW
SEEELLPESN IIQQELLELN TRGWWTVASQ PAVNGIPSRD PTFGWGPQHG FVFQKAFVEL
FIPSSDWAGL VARLNEVTDK TICFYAANAA GDFVSSDSSG GLVLEGTEAS TNAVTWGVFP
GKEIITPTII EEVSFRAWAK EAFKIWSEWA KVYGKGSESE ALLERIRSEY WLVNIIHHDY
VDRDALWKLL SGEREN
//
