ID A0A066XVA5_COLSU Unreviewed; 4370 AA.
AC A0A066XVA5;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=CSUB01_00250 {ECO:0000313|EMBL:KDN69666.1};
OS Colletotrichum sublineola (Sorghum anthracnose fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum graminicola species complex.
OX NCBI_TaxID=1173701 {ECO:0000313|EMBL:KDN69666.1, ECO:0000313|Proteomes:UP000027238};
RN [1] {ECO:0000313|Proteomes:UP000027238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TX430BB {ECO:0000313|Proteomes:UP000027238};
RX PubMed=24926053; DOI=10.1128/genomeA.00540-14;
RA Baroncelli R., Sanz-Martin J.M., Rech G.E., Sukno S.A., Thon M.R.;
RT "Draft genome sequence of Colletotrichum sublineola, a destructive pathogen
RT of cultivated sorghum.";
RL Genome Announc. 2:E0054014-E0054014(2014).
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KDN69666.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JMSE01000487; KDN69666.1; -; Genomic_DNA.
DR STRING; 1173701.A0A066XVA5; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_7_0_1; -.
DR OMA; NERQMTR; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000027238; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000027238}.
FT DOMAIN 1957..2095
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2614..2769
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2956..3122
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1660..1687
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3204..3295
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3444..3485
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4370 AA; 496102 MW; A4FCF6147AFC85C8 CRC64;
MEVASPQLPG ANGVVSPIAD PSIDPSRVLD HIALACQVAL GATNEDLESP GSLLHKHRYS
DTLQRCTRFA TDTPNALYIQ KDLLPASTIQ NGTEDSSSFD PPGNVLLRRY TANQANAESP
AYTYSLTTEI SSSPTTVSCL VLLKQRPGPI DPTIPLTSQI LLTNLPGPAT LNATAGDQGP
STSPFEILHS YVHNALAPYF DANTRSQIAN GARGRADVDS KTGIPVTKKR WNDLELSLLH
LQQNVEIPEV SLMFHTMVQN ALEEAESRHS KPSLDLIPST VLSDSTFLNS LQNNVNSWIK
SIQVITRMTR DPADSAKDFK FTASQEVNFW LSMESALEGI EGQLRSEGVL LTLEILKHAK
RFQATVSFTA DTGLKEAMEK VQKYNQLMRD FPLDELLSAT SMSKVKDAII QIFGHLNRKL
RICPYPIRRA LPLVEAISGD LDEMLHRLLP GTELVNLDYN EFKAIMKASE DIFTTWDESI
KEFTNVAREV TRRRNEKFIP IKVNPKHAEL QGRLKYVSTF RDNHEQLQRT IVNVLGPKAT
VSGLTETTNT NGVVVVEEMG DVDAVEEVKQ AWEALKNVDL LDVSAEGTER WAKAENMYNE
RTSRVENSII ARLRDRLATA KNANEMFRVF SKFNALFVRP KIRGAIAEYQ NQLMEHVKQA
IHGLHERFKQ QYGHSEAHAM AQLRDLPPVS GAIIWARQIE HQLDNYMKKV EDVLGSEWAI
HAEGQKLQSE SNLFRKKLDT QTIYKTWLDD VQRRQISISG FLFDIRRMRS TGGNYELLVN
FDPQVITLFK ETRNLMWQNY AVPHSVNNVS KDAKRVYPFA VSLMESVRTF SQTMRQISEM
GEEAVLVYGY RNDVYALVSR GVPLRWESFV NSHEIFFSTK NNAALPNVSE FGLSKPSESK
HSLFIREFAA AVSLLQVKTA SLASIHATVE KALAELNTCP YEASAFTSRL ETIQRAVDQL
NLEQYVNLPY WVENMNQKLK EVLLARLQDA IQAWIQAFED DYLDDGRRKQ ATESGEEPVQ
EGPAIKRLIH ELSMRNQVIY LEPPLEYARS SWFVQLHEWL GIVCNLKKIK ATRYQMTLTT
TTLDEPHFDD LPSDCTDLLS RVYVSIEKKL REIGTYVDKW LQFQSLWDLQ SEQVYEALGD
QLARWLQLLQ EIRKTRQTFD TQEVSRQFGH ITIDYDQVQT KVNAKYDQWQ HEILMKFASR
LGNRMREVHA EIEKARRDLE SQGLDASSTA QAVQFITVVQ ACRRNVKLWA PEIDMFRQGQ
STLVRQRYQF PSDWLHIEQI DSSWESLTEI LEKKSKIVQD QTDALKSKII AEDKIVNDRI
AEVAVQWNDE KPVSGTTQPD VASATLASFE ARISKLQSDF EMVARAKEAL DIPTSADTSL
STILEEVQDF QSVWSNLSTI WASLNETREI LWTAVQPRKI RSKIDDLIKS TKEMPSRMRQ
YAAFEHVQTI LRGLLKVNSI LSDLKSEAIR DRHWIKIYKQ IKPGKRYSPV AMTLGDVWDL
NLVATEVIVR DIIAQAQGEM ALEEFLKQVR ETWSTYGLEL VNYQNKCRLI RGWDDLFAKC
SENLNSLQAM KHSPYYKEFE EEASSWEDKL NRVHVLFDVW IDVQRQWVYL EGVFTGNADI
KHLLPVESSR FQNINSEFSA VMKKVYKQPY VLDVLTIPNV QKSLERLAEL LNKIQKALGE
YLEKERVSFP RFYFVGDEDL LEMIGNSNDT LRIAKHFKKM FAGLSGLIMD DETIISGFTS
KEGEAVRLKK EISLAKTPKI NDWLALLENG MKNTLAELLA EAVDQYTPIF ESEKIDKEAM
DSFMEAFPSQ IVVLATQVVW TTAVERSLGD GGKTLQSLYD REVQVLRLLA DTVLGDLEII
LRKKCEQLIT ECVHQRDAIE KLISLNATTP THYWWLLQMR YVYNPEGDFP QRLQVKMANA
TLAYGFEYLG VPDRLVRTPL TDRCFLTLTQ ALQQRLGGSP YGPAGTGKTE SVKALGLQLG
RFTLVFCCDD TFDFQAMGRI FLGICQVGAW GCFDEFNRLE ERILSAVSQQ IQNIQLGLKQ
GAEDEKAQTE LVGRQLRVNA NTGIFITMNP GYAGRSNLPD NLKKLFRSVA MSKPDKELIA
EVMLYSQGFN QAKQLSKHTV PFFDQCAARL SKQAHYDFGL RALKSVLVSS GGLKRARLLE
SDGNLGAEEV VEPEIIVQSI RETIAPKLIK SDVEILTEVE EACFPGVKYV PANLHKLEEA
IRTLADERQL VVNDTWMTKV LQLYQIQKIH HGVMMVGNSG TGKSAAWTLL LDALQKVEGV
EGVQHVIDSK VMSKEALYGN LDSTTREWTD GLFTSILRKI VDNLRGEDSK RHWIVFDGDV
DPEWVENLNS VLDDNKLLTL PNGERLNLPA NVRIMFEVET LKYATLATVS RCGMVWFSED
TVTPTMMLEH YLGTLRSKPF EDLDEDSVAA GQSPAKALAI QSQVADLLGA FLSGEDFLVA
TLKEAEGYNH IMDFTVARVL NTLFSLLNKA VRDMIEYNAQ HSDFPLDPEQ VEAFTAKKLL
LALVWALTGD CPLNDRKTFG DAVCGLASFG NPPLDGNSSL IDFDVTLPMA EWAPWQNQVP
TIEVNTHSVT QTDVVIPTLD TVRHEDVLYS WLAEHKPLLL CGPPGSGKTM TLFSALRKLP
NMEVVGLNFS SATTPDLLIK TFEQYCEYKK TLNGVMLSPT QIGRWLVIFC DEINLPAPDK
YGTQRAISFL RQLVEHNGFW RTSDKSWVTL DRIQFVGACN PPTDAGRTPL GARFLRHAPL
IMVDYLGELS LLQIYGTFNS AVLKIIPSLR GYSEPLTQAM VKLYLESQQR FTPKIQPHYV
YSPRELTRWV RGIYEAIRPL ETLSIEGLVR IWAHEALRLF QDRLVAEDER QWTDDAVRRI
ALELFPTIDD QKALGGPILF SNWLSKNYVP VDREQLRDFV KARLKTFCEE EVDVPLILFN
DVLEHVLRID RVFRQPQGHL ILIGVSGSGK TTLSRFVAWM NGLKVFQIKV HGKYSGEDFD
DDLRDVLRRC GCKGEKICFI MDEANVLDSG FLERMNTLLA NAEVPGLFEG DEFAALMTAC
KEGAQRQNLH LDSPEELYKW FTQQIVKNLH VVFTMNPPEG GLGSKAATSP ALFNRCVLNW
FGDWSDQALF QVGHELTHSM DLDRPNFQAP DSIPVAYRGL SLPPSHRETI VNSMVYIHYS
LQRFNTKLFK QQGKVTFLTP RHFLDFVAQY VKLYNEKRED LEEQQRHLNV GLEKLRDTVD
KVRDLRVSLA EKKSQLEKKD AEANEKLQRM VADQREAEQR KNTSLEIQVA LEKQEAEVAT
RRKVVLEDLA KAEPAVEEAK ASVSNIKRQH LTEVRSMGNP PQGVRLALES VCALLGHKVN
DWRMIQGIIR RDDFIASIVN FDNERQMTKS LRVKMRNEFL SNPEFTFDKV NRASKACGPL
VQWVEAQVSY SEILDRVGPL RDEVDALEEQ ALQTKAEAKA VENTISTLES SIAQYKTEYA
ALISETQAIK SEMSKVQFKV DRSVKLLDSL SSERVRWEEG SKSFETQIST LVGDVLVAAA
FLAYSGLYDQ TFRKSMMDDW LHQLQLSGIL FKPHNPVTEY LSTADERLSW QENSLPVDDL
CTENAIILKR FNRYPLIIDP SGRVTEFLQK ESKERRLTVT SFLDDSFTKQ LESSLRFGNP
ILIQDAEYLD PILNHVLNKE YQKTGGRVLI QLGKQQIDFS PSFKIYLSTR DPSATFAPDI
CSRTTFVNFT VTQSSLQTQS LNEVLKSERP DVDERRSNLI KLQGEFKIHL RQLEKRLLQA
LNESRGNILD DDNVIETLET LKTEAAEISD KMNNTEGVMA EVEEITQQYS IIARSCSTVF
AVLEQLHYLN HFYQFSLQYF LDIFHSVLHG NKNLANETNH NIRRDIIVKD LFVTTFKRTA
LGLLQKDRIT LAMLLAQASP YKMDKTVIDI ILDDRVEGRD LSTDKDAKDE AFARAGRMNL
LKEKLDKVPS ADWDKFLTEE LAENFVPQIW EDNTEAFDQA LQSLLLVKLF RLDRFVPAAE
RFVTLVFGSD TFDIVEDLKE TVSQVPATRP ISLVSSPGFD ASYKVDNLVE RMRIKCTNIA
MGSNEGLASA DKAISNAAQL GNWVLVKNVH LAPTWLQSLE KRMESLNPHS DFRLFLSMES
SPKIPVNLLR ASRVLMYEQP AGVRANMKDS MTSLSTRATK APVERTRLYL LLAFLHAVVQ
ERLRYAPSLG WKGFWEFNDS DYECSAFIID TWIENAAGAR TNIAPQSIPW DMLRYLVTET
YGGKIDNEDD FKQLNQLVHS FLTPSAYDVG HKLVEGAENQ EGSLIVPSGT SMQDFMAWIH
KLPEREPPTY LGLPANAEKL LLVGLGRSLI SNLKKVTELL EEGEQLMVEA
//
