ID A0A066YM39_9ACTN Unreviewed; 730 AA.
AC A0A066YM39;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Urease accessory protein UreD {ECO:0000256|HAMAP-Rule:MF_01384};
GN Name=ureD {ECO:0000256|HAMAP-Rule:MF_01384};
GN ORFNames=KCH_71030 {ECO:0000313|EMBL:KDN81009.1};
OS Kitasatospora cheerisanensis KCTC 2395.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Kitasatospora.
OX NCBI_TaxID=1348663 {ECO:0000313|EMBL:KDN81009.1, ECO:0000313|Proteomes:UP000027178};
RN [1] {ECO:0000313|EMBL:KDN81009.1, ECO:0000313|Proteomes:UP000027178}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KCTC 2395 {ECO:0000313|EMBL:KDN81009.1,
RC ECO:0000313|Proteomes:UP000027178};
RA Nam D.H.;
RT "Draft Genome Sequence of Kitasatospora cheerisanensis KCTC 2395.";
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for maturation of urease via the functional
CC incorporation of the urease nickel metallocenter. {ECO:0000256|HAMAP-
CC Rule:MF_01384}.
CC -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC hydrolysis-dependent molecular chaperone, activating the urease
CC apoprotein by helping to assemble the nickel containing metallocenter
CC of UreC. The UreE protein probably delivers the nickel.
CC {ECO:0000256|HAMAP-Rule:MF_01384}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362002};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362002}. Cytoplasm
CC {ECO:0000256|HAMAP-Rule:MF_01384}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the UreD family. {ECO:0000256|HAMAP-
CC Rule:MF_01384}.
CC -!- SIMILARITY: Belongs to the ammonia transporter channel (TC 1.A.11.2)
CC family. {ECO:0000256|ARBA:ARBA00005887, ECO:0000256|RuleBase:RU362002}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KDN81009.1}.
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DR EMBL; JNBY01000155; KDN81009.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A066YM39; -.
DR PATRIC; fig|1348663.4.peg.6872; -.
DR eggNOG; COG0004; Bacteria.
DR eggNOG; COG0829; Bacteria.
DR HOGENOM; CLU_379378_0_0_11; -.
DR Proteomes; UP000027178; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR Gene3D; 1.10.3430.10; Ammonium transporter AmtB like domains; 1.
DR HAMAP; MF_01384; UreD; 1.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR001905; Ammonium_transpt.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR InterPro; IPR002669; UreD.
DR NCBIfam; TIGR00836; amt; 1.
DR PANTHER; PTHR43029; AMMONIUM TRANSPORTER MEP2; 1.
DR PANTHER; PTHR43029:SF10; AMMONIUM TRANSPORTER MEP2; 1.
DR Pfam; PF00909; Ammonium_transp; 1.
DR Pfam; PF01774; UreD; 1.
DR SUPFAM; SSF111352; Ammonium transporter; 1.
PE 3: Inferred from homology;
KW Ammonia transport {ECO:0000256|RuleBase:RU362002};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|HAMAP-Rule:MF_01384};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01384};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362002};
KW Nickel insertion {ECO:0000256|HAMAP-Rule:MF_01384};
KW Reference proteome {ECO:0000313|Proteomes:UP000027178};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362002};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362002}; Transport {ECO:0000256|RuleBase:RU362002}.
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 332..350
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 389..407
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 419..440
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 460..478
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 490..508
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 520..541
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 548..568
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 574..594
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 606..627
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT TRANSMEM 647..666
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362002"
FT DOMAIN 300..678
FT /note="Ammonium transporter AmtB-like"
FT /evidence="ECO:0000259|Pfam:PF00909"
FT REGION 150..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..285
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 730 AA; 77231 MW; 07275A388369B725 CRC64;
MRPLRLDPDR PGDAYVFLMA TGGGVTQADR YRIDARCGPD TRVHLTTQAA TKVFRMEQDY
ASQRVHLTAE RGAYLEYLPD PLIPFRDARY YQHTTVTVAS GGTVVLGETL TAGRLARGER
HDYRVVATDL EITRPDGALL AVDTQRLVTG GDRRTVTGPP CSPDTTTSPR CSWSATSAPP
ARSPTPCTAP STGWAPTTAS PPSPRSPAPG CACWRTARPA PRPPSTPPGG PSACCSPARP
RRLCARPDRP AAPGRPRAGR PNSNSPPGPG SVPYPQEVPR KCPCSPRPAD APAYNAGDTA
WLLASTAMVL LMTPGLAFFY GGMVRLKHIL MMLKMSFAAL AFGSLVWWAL GYTLAFGPDV
GGAGLIGNVD RAFFRGIQLN TLTGAIPTYI FATFQMGFAI VTVALISGSV ADRARMRGWL
VFVPLWLLLV YAPAAHWVFA PDGWIHDKLG ALDFAGGLPV ELNSGAAGLA VAVALRGPRD
WARREERPNN IPLVVIGVGL LWFGWFGFNS GSALNDQGTA AAAFLNTQLG GAAAMVTWPL
VEKWRTGRVS TTGVVSAGVA GMVAITPACG EINPLGAVIT GLVAGLVCAF AVTLKYRFGV
DDTLDVVGVH GVGGITGLIM VGLFATARIS GREGLFYGGG WSLLGKQVLA VLAMAAFSFL
VTWLLAKLVH AAVGFRAEAA YAHVPGGEAE TAYDTLTAER LTTLAAEGAA RSDTELVHRI
AELLRARRQD
//
