ID A0A066YVN0_9ACTN Unreviewed; 726 AA.
AC A0A066YVN0;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Zinc metalloprotease {ECO:0000313|EMBL:KDN81995.1};
GN ORFNames=KCH_61490 {ECO:0000313|EMBL:KDN81995.1};
OS Kitasatospora cheerisanensis KCTC 2395.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Kitasatospora.
OX NCBI_TaxID=1348663 {ECO:0000313|EMBL:KDN81995.1, ECO:0000313|Proteomes:UP000027178};
RN [1] {ECO:0000313|EMBL:KDN81995.1, ECO:0000313|Proteomes:UP000027178}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KCTC 2395 {ECO:0000313|EMBL:KDN81995.1,
RC ECO:0000313|Proteomes:UP000027178};
RA Nam D.H.;
RT "Draft Genome Sequence of Kitasatospora cheerisanensis KCTC 2395.";
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M4 family.
CC {ECO:0000256|ARBA:ARBA00009388}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KDN81995.1}.
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DR EMBL; JNBY01000126; KDN81995.1; -; Genomic_DNA.
DR RefSeq; WP_035867780.1; NZ_KK853997.1.
DR AlphaFoldDB; A0A066YVN0; -.
DR MEROPS; M04.017; -.
DR PATRIC; fig|1348663.4.peg.5950; -.
DR eggNOG; COG3227; Bacteria.
DR HOGENOM; CLU_008590_5_1_11; -.
DR OrthoDB; 291295at2; -.
DR Proteomes; UP000027178; Unassembled WGS sequence.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09597; M4_TLP; 1.
DR Gene3D; 3.10.170.10; -; 1.
DR Gene3D; 3.10.450.40; -; 1.
DR Gene3D; 3.10.450.490; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011096; FTP_domain.
DR InterPro; IPR023612; Peptidase_M4.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR InterPro; IPR001570; Peptidase_M4_C_domain.
DR InterPro; IPR013856; Peptidase_M4_domain.
DR PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR PANTHER; PTHR33794:SF1; BACILLOLYSIN; 1.
DR Pfam; PF07504; FTP; 1.
DR Pfam; PF01447; Peptidase_M4; 1.
DR Pfam; PF02868; Peptidase_M4_C; 1.
DR PRINTS; PR00730; THERMOLYSIN.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000313|EMBL:KDN81995.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:KDN81995.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000027178};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..726
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038366751"
FT DOMAIN 76..116
FT /note="FTP"
FT /evidence="ECO:0000259|Pfam:PF07504"
FT DOMAIN 217..369
FT /note="Peptidase M4"
FT /evidence="ECO:0000259|Pfam:PF01447"
FT DOMAIN 373..545
FT /note="Peptidase M4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02868"
FT REGION 254..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..576
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..608
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 363
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
FT ACT_SITE 448
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
SQ SEQUENCE 726 AA; 75023 MW; E44815CA71AED281 CRC64;
MSRKNALAAA VAAALTLGTV TVAATQSTAA ASGSSARPGA GFRAMTADAR GEAIRTADRE
AAAVARSLGL GADERLVAKD VLFDTDGARH VRYDRTYRGL PVIGGDLVVH YGKDGRSTGS
DQAHQGAIRM AGTAPKLTAA DASAAAVKHA KHVKNARTDS SDSSALVVYA VGKVPVLAYR
STVTGEGETG PASREAVIVD AASGAPLDQY ELHQGITGTG NGVTVGQVSI ETTQSGSGYT
LTDAAHGSTV VYDSYNSPQS NPKQNARTFS KTTNTWGTGT TSSRESAAVD ASYGLAKTWD
FYQSTFNRSG IRNDGRGAPA YVHVDSSLLN AFYDDDCFCM FFGDGSSQNS NTPVTALDVA
GHEMSHGVTA ATANLNYSGE SGGLNEATSD IFGTMVEFYA NNSSDPGDYY IGEKLNMPNG
YMRRMDNPSV DGNSLSCYSS GAGSVDVHYS SGIANHFFYL AAEGTGAKTI GGRSHNGTTC
NNDTFTGIGR DKAAAVWYRA LTTYMTSTTN YAGARTATLQ AAADLYGANS QERYLVSKAW
AAVSVGTALP DPGTGSPSPS PSGSTSPSPS PSPSSSGSPN PGNALTNGAF EQGTAGWTQS
DNDITNSTLQ PAHGGSWYAW MMGYGTSAVE SLSQSNIAVP ASGSPKLTFW LKVSTQESGS
TAYDTLKVKV NGATLATYSN ANASAGYVQK TVDLSAYKGQ SVKLEFAGTE DAYLATVFLI
DDVSIG
//
