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Database: UniProt
Entry: A0A066Z3Z1_9ACTN
LinkDB: A0A066Z3Z1_9ACTN
Original site: A0A066Z3Z1_9ACTN 
ID   A0A066Z3Z1_9ACTN        Unreviewed;       535 AA.
AC   A0A066Z3Z1;
DT   03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT   03-SEP-2014, sequence version 1.
DT   05-JUN-2019, entry version 30.
DE   SubName: Full=Histidine kinase {ECO:0000313|EMBL:KDN88177.1};
DE            EC=2.7.13.3 {ECO:0000313|EMBL:KDN88177.1};
GN   ORFNames=KCH_00270 {ECO:0000313|EMBL:KDN88177.1};
OS   Kitasatospora cheerisanensis KCTC 2395.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Kitasatospora.
OX   NCBI_TaxID=1348663 {ECO:0000313|EMBL:KDN88177.1, ECO:0000313|Proteomes:UP000027178};
RN   [1] {ECO:0000313|EMBL:KDN88177.1, ECO:0000313|Proteomes:UP000027178}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KCTC 2395 {ECO:0000313|EMBL:KDN88177.1,
RC   ECO:0000313|Proteomes:UP000027178};
RA   Nam D.H.;
RT   "Draft Genome Sequence of Kitasatospora cheerisanensis KCTC 2395.";
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KDN88177.1}.
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DR   EMBL; JNBY01000003; KDN88177.1; -; Genomic_DNA.
DR   RefSeq; WP_035857896.1; NZ_KK853997.1.
DR   STRING; 1348663.KCH_00270; -.
DR   EnsemblBacteria; KDN88177; KDN88177; KCH_00270.
DR   PATRIC; fig|1348663.4.peg.16; -.
DR   OrthoDB; 1755994at2; -.
DR   Proteomes; UP000027178; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR007891; CHASE3.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF05227; CHASE3; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000027178};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:KDN88177.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Reference proteome {ECO:0000313|Proteomes:UP000027178};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669,
KW   ECO:0000313|EMBL:KDN88177.1};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM     20     43       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    196    216       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      218    270       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      299    513       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
FT   REGION      516    535       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A066Z3Z1}.
FT   COILED      114    134       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   535 AA;  58585 MW;  E8487114AD6E50C4 CRC64;
     MHDRRPPRGR SLSTWTTRRW LRVGASLSLA VLAVLGVLGF WVLNRTQNLT TDLVDVRTPA
     TSAALRLESA LVNQETGTRG YALTGNPELL EPYRQGLADQ KTQTDRLVQL LHGNDSALAD
     LAAVEDAAAR WQREVAGPIA AAPAGTPVAQ SAESAAGGKT AFDRVRAELA RQQDHLRSDR
     AAARADLVST MRVRNWVFAA IGVVIAVLTA LIFEGLRRGI TRPLEQLGSD ARRIGAGDFD
     HPIAATGPAD LRRLSTDIDS MRRRLVEELA FTEQARLRLD AQAAELQRSN TELEQFAYVA
     SHDLQEPLRK VSSFTQLLQR RYGGQLDARA DQYIDFAVDG ANRMQVLIND LLDFSRVGRV
     HHNHQDVDLE DVLDRTLDVL SDSIAEAGAQ ITHDPLPTVF ADPTQMGMLW QNLIGNAVKF
     RRPEIPPRIH VSAERRDGLY HFAVTDNGIG IAPEFAEKVF VIFQRLHTKD AYSGSGIGLA
     MCKKIVEFHG GTIAIDPDHV EGTRVVLTLD AEPAEALLPP TPAGPTPAAA EQEAR
//
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