ID A0A067BU69_SAPPC Unreviewed; 1003 AA.
AC A0A067BU69;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=SH2 domain-containing protein {ECO:0000259|PROSITE:PS50001};
GN ORFNames=SPRG_12621 {ECO:0000313|EMBL:KDO21803.1};
OS Saprolegnia parasitica (strain CBS 223.65).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO21803.1, ECO:0000313|Proteomes:UP000030745};
RN [1] {ECO:0000313|EMBL:KDO21803.1, ECO:0000313|Proteomes:UP000030745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO21803.1,
RC ECO:0000313|Proteomes:UP000030745};
RX PubMed=23785293;
RA Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA Russ C., Tyler B.M., van West P.;
RT "Distinctive expansion of potential virulence genes in the genome of the
RT oomycete fish pathogen Saprolegnia parasitica.";
RL PLoS Genet. 9:E1003272-E1003272(2013).
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DR EMBL; KK583280; KDO21803.1; -; Genomic_DNA.
DR RefSeq; XP_012207481.1; XM_012352091.1.
DR AlphaFoldDB; A0A067BU69; -.
DR STRING; 695850.A0A067BU69; -.
DR EnsemblProtists; KDO21803; KDO21803; SPRG_12621.
DR GeneID; 24134564; -.
DR KEGG; spar:SPRG_12621; -.
DR VEuPathDB; FungiDB:SPRG_12621; -.
DR OMA; RQCEIPL; -.
DR OrthoDB; 47461at2759; -.
DR Proteomes; UP000030745; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00173; SH2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR10039; AMELOGENIN; 1.
DR PANTHER; PTHR10039:SF14; NACHT AND TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06670); 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF13676; TIR_2; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 901..990
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 254..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1003 AA; 111829 MW; D1814B2213338868 CRC64;
MPTPCDQCLG TNTMQLLQRE LIVCGDCEHV ASSNNPTSQP TLAIYERPKL HIFLSYGHDR
YQQLAMRLKD QLQSRGHLVW VDVEKLTPGC DWEEGIANGL TWAKEAQENG RVLLLMTPHA
LRRPDGYCLN EIARATQLKL HIFPTLVCES EPPPAISMLP YFDMQDCMPS LEIAQTLDSK
SPEWLAAVNS RLNSPQFRAK SLQLFTLLEM CDSMTNNMVT VVAGVENLGL FEAHASSTKI
GHVPTYRKIL SPKHTSASEQ SFQETPKHRG SGFGTPLVPA DEPRGASPAE STKYVFVFDA
TSAPLAMKLH ADLTADGFLI HAHCAPSPLL PHARRDAITW AETGKMLLFL TPQSVGRPHG
VCLNDISAAM SSNVGFVPLM VRQCEIPLSI CRIQWLDLSD CLIDVDGVGS VNDAKYPQRL
AQIATALRGK LDHDGLQARL FSIFSPFSFQ TNKYTQGFAG REWVLDQLDQ WKQTHDQVFW
VTGQIGTGKS ALAAYIIQSR PEVRAFHLVC KEDEQTQSHR RCVLSLAYQL TTQLPEYASF
LQQGSPLEEV VPVSTVVELL DILLVAPLRA IAEPATTPLV ILLDGLDSLE DTQETDNCLV
SALPALLQKL PSWVRVILTS REDPVVMRKL QGFAPQIALD KCADHSRQDI MSYLQKALLP
YLPSTTAGVV PEATLQFIAG RAEGLFLYAS HIVHALSQHR LTLDNLEGFP TGMGGYLRQF
FESQFTPEHY KEHIRPLLEV LCAAYEPLTL DMLRAIMQWD SYVQHEMLAS FKSLLYVTDS
NVLKPFHTSV LEWLQDSNAA GPFLPEHGHE RIGLWAWKEY STVLKATTDV SSINFELEPS
SEPDLVDQDR GPIYIIRHAL NHLREANTED SIRCMQNFST DEKFQLARRL ITLRQSGLES
FFHGDIDRVA AQAVLLPVGT PGAFLIRYSA NQKSYCASFI DKIVDGQPQI KHNVIYHLES
GAYSAVQPKD VQPTTPIFSD LLSFVEAYQR KGVLRTAIPK GSA
//