ID A0A067C6G7_SAPPC Unreviewed; 951 AA.
AC A0A067C6G7;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Eukaryotic translation initiation factor 5B {ECO:0000256|ARBA:ARBA00013824};
DE AltName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00032478};
GN ORFNames=SPRG_10254 {ECO:0000313|EMBL:KDO24720.1};
OS Saprolegnia parasitica (strain CBS 223.65).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO24720.1, ECO:0000313|Proteomes:UP000030745};
RN [1] {ECO:0000313|EMBL:KDO24720.1, ECO:0000313|Proteomes:UP000030745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO24720.1,
RC ECO:0000313|Proteomes:UP000030745};
RX PubMed=23785293;
RA Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA Russ C., Tyler B.M., van West P.;
RT "Distinctive expansion of potential virulence genes in the genome of the
RT oomycete fish pathogen Saprolegnia parasitica.";
RL PLoS Genet. 9:E1003272-E1003272(2013).
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
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DR EMBL; KK583239; KDO24720.1; -; Genomic_DNA.
DR RefSeq; XP_012204600.1; XM_012349210.1.
DR AlphaFoldDB; A0A067C6G7; -.
DR STRING; 695850.A0A067C6G7; -.
DR EnsemblProtists; KDO24720; KDO24720; SPRG_10254.
DR GeneID; 24132373; -.
DR KEGG; spar:SPRG_10254; -.
DR VEuPathDB; FungiDB:SPRG_10254; -.
DR OMA; EFAVMLC; -.
DR OrthoDB; 169393at2759; -.
DR Proteomes; UP000030745; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd03703; aeIF5B_II; 1.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR029459; EFTU-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 5B; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF14578; GTP_EFTU_D4; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000030745}.
FT DOMAIN 360..578
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 112..200
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 217..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..272
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 951 AA; 104006 MW; 55FEC2182D07DA8A CRC64;
MPPKKGKKPA PAKKAVSGDD DWDILNEFAT PAPAPVEAAP APAEPTTEAE PAAVDDAVAA
HLASLGISAS AAADKKKKKK GKKKGDDAKD EAPAAAAAPA PAGPKKPLSA AAKALLERQA
ALKAEQERLQ AIQEEEERLE REAEAARLEV IRKKEEAAER KRLAKKAKVE AAKAEGTYMT
KAQKLKAQRA QAALEAMKAQ GLVSIAADEE KKPVVYTNTK KNKKQPKKEE DVVEEVKPAT
EDVPDAWDAS DNEDKAEADA PDAWDDDEWD DSALIATIQQ KVEETTTTAA EDEVEDLIEL
EKEKRRSRQA EQEAEAALAA EAETVRSKAK QEEDRKKREA AERRRVREEE ARAAISEDNL
RSPICCIMGH VDTGKTKLLD NIRKTKVQDA EAGGITQQIG ATFFPVEAIK QKTAALQKVT
NLQYKLPGLL VIDTPGHESF TNLRSRGSSL CDIAILVVDI MHGLEPQTLE SLRLLRAKRA
PFVVALNKID RCYSWKTCPD MPIRDALALQ NEHVVREFED RAKKIMVEFA EQGLNAEVYW
RNKDLGRTVS LIPTSAISGE GVPDLLMMLT KLTQERMAKS LAFVDILQCT VLEVKVIEGL
GTTIDTILVN GSLSEGQTIV VCTLEGPVVS TIRSLLTPHP MKEIRVKGEY IHHQTIKAAM
GVKICAQGLE KAVAGTQIHV VGPDDDVEEL KDSVMSDLSN IMDSVNATKR GVMVQASTLG
ALEALLEFLR SCDPPIPVAC VNIGPVHKKD VVRASVQLEH NKEYATILAF DIKIQNDANE
LANELGVRIF TADIIYHLFD QFTAYMDNIK ALRREQFADV AVFPVVLRII PTCVFNKKDP
IILGVDIEDG ILKVGTPLVA IVGGALVSVG RVGSIEKDNK PTETAKKGAS VAVRIESDSN
VTYGRHFDHT AKLYSHLSRA SIDALKENFK EDLAKDDWRL VIRLKGVFGI I
//
