ID A0A067C850_SAPPC Unreviewed; 965 AA.
AC A0A067C850;
DT 03-SEP-2014, integrated into UniProtKB/TrEMBL.
DT 03-SEP-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=CSC1/OSCA1-like 7TM region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=SPRG_11000 {ECO:0000313|EMBL:KDO22686.1};
OS Saprolegnia parasitica (strain CBS 223.65).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae;
OC Saprolegnia.
OX NCBI_TaxID=695850 {ECO:0000313|EMBL:KDO22686.1, ECO:0000313|Proteomes:UP000030745};
RN [1] {ECO:0000313|EMBL:KDO22686.1, ECO:0000313|Proteomes:UP000030745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 223.65 {ECO:0000313|EMBL:KDO22686.1,
RC ECO:0000313|Proteomes:UP000030745};
RX PubMed=23785293;
RA Jiang R.H., de Bruijn I., Haas B.J., Belmonte R., Lobach L., Christie J.,
RA van den Ackerveken G., Bottin A., Bulone V., Diaz-Moreno S.M., Dumas B.,
RA Fan L., Gaulin E., Govers F., Grenville-Briggs L.J., Horner N.R.,
RA Levin J.Z., Mammella M., Meijer H.J., Morris P., Nusbaum C., Oome S.,
RA Phillips A.J., van Rooyen D., Rzeszutek E., Saraiva M., Secombes C.J.,
RA Seidl M.F., Snel B., Stassen J.H., Sykes S., Tripathy S., van den Berg H.,
RA Vega-Arreguin J.C., Wawra S., Young S.K., Zeng Q., Dieguez-Uribeondo J.,
RA Russ C., Tyler B.M., van West P.;
RT "Distinctive expansion of potential virulence genes in the genome of the
RT oomycete fish pathogen Saprolegnia parasitica.";
RL PLoS Genet. 9:E1003272-E1003272(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; KK583264; KDO22686.1; -; Genomic_DNA.
DR RefSeq; XP_012206601.1; XM_012351211.1.
DR AlphaFoldDB; A0A067C850; -.
DR EnsemblProtists; KDO22686; KDO22686; SPRG_11000.
DR GeneID; 24133079; -.
DR KEGG; spar:SPRG_11000; -.
DR VEuPathDB; FungiDB:SPRG_11000; -.
DR OMA; IRDDNIS; -.
DR OrthoDB; 69158at2759; -.
DR Proteomes; UP000030745; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR PANTHER; PTHR13018:SF98; TO DEHYDRATION PROTEIN, PUTATIVE, EXPRESSED-RELATED; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030745};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..965
FT /note="CSC1/OSCA1-like 7TM region domain-containing
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001634188"
FT TRANSMEM 117..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 553..579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 751..784
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 805..825
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 831..851
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 184..275
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 561..823
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
SQ SEQUENCE 965 AA; 107807 MW; 9308664AE51B8A35 CRC64;
MALHRTWALL PTLLAALVAL AAADVVTLHV PTNATNDLLV ALSLSANDTR AMPTIAPSPL
VLRTGATSVN FTITGAIPGR YPLSYKLVSL VSGNTTYELS AETLVVFIVN DQWQSTLSQF
GINVALVLGG VGLFLWRRGA KRDLWFWGAP IEGVFEPDPF RSDETMPSLL AAPTWQERGR
RFWMLGCDDA YIVDACGVDA ALFLRFNLDA AKLFSALTIL SCALLLPINF VSGDGPTTSS
QQATIANVPV QSPYFWGHVV MCYLTAGAVL FFVFRQNRRL EYLHLNDTTL IGPRSVFVQA
GLPLDVTRHE LRQWFLADYP EDIDQVYVVA DLSRVYTVLE QRMRWRNDLQ RLETVYMSPS
SLPLSPWLRY CPGGACCPSP ADIWFDYLAR RPCQSHAHVA SRPLREPLLS ENMSTPKDAV
TDDDETEMVP PRIVAKVAAL RAQLAAVPED ILSNYARRTG TGAAFVVFNS NRARDQFLDR
FRQTQAPLSQ CVASTAATLC RRRPRRATVD SSGPSRLARH LSDLVVHPAP EPHDLKWAKM
TYRPHSLRRF CQFGLYHALT IVLLLLFSTP ASVLLYFNLQ PGSDVYGRVL TSDSLITGFL
HTYLPTLFLV CVNWVLLTVL FYVSFLEPWF TESRRMRSFL SKGFAYLFLF DFVPSIGVTA
VYAATKTSSQ VAFGGASSRE VKYVNDFLYK LCSNFFVGYI LQLTCLGSLT QLLRIGEKLF
YQPWVISRAV TTDEVQAARE PWPFYFGYDY AVLLSVFTIG LLGSVLSPYL VPCAAVFFFA
KYYVSKYNFV YVHPKTPGRG NVARAAYSLA LVCLLLFELA MTSILSQLGN ANQWLALVLL
TCATLGVFVY WRVVVYRALE TETSPTPVEV EAPTTQLRRQ QSMELSRAVF QAHSLGEMEA
LVHARPTQAY INPYDVGLQM LSVLHRYQAL RTAKLRDAFN LLKQQQHEVC SPSTAAASDP
SENVD
//
